GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:PLIN1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Plin1 (synonyms: Peri, Plin) | |
| Protein Name(s) | Perilipin-1
Lipid droplet-associated protein Perilipin A | |
| External Links | ||
| UniProt | Q8CGN5 | |
| EMBL | AY161165 AK031445 CH466543 BC096685 | |
| CCDS | CCDS21385.1 | |
| RefSeq | NP_001106942.1 NP_783571.2 | |
| UniGene | Mm.254917 | |
| ProteinModelPortal | Q8CGN5 | |
| BioGrid | 222244 | |
| PhosphoSite | Q8CGN5 | |
| MaxQB | Q8CGN5 | |
| PaxDb | Q8CGN5 | |
| PRIDE | Q8CGN5 | |
| Ensembl | ENSMUST00000032762 ENSMUST00000178257 | |
| GeneID | 103968 | |
| KEGG | mmu:103968 | |
| UCSC | uc009hyu.2 uc009hyw.1 | |
| CTD | 5346 | |
| MGI | MGI:1890505 | |
| eggNOG | NOG75006 | |
| GeneTree | ENSGT00500000044795 | |
| HOGENOM | HOG000261608 | |
| InParanoid | Q8CGN5 | |
| KO | K08768 | |
| OMA | ASVCNAY | |
| OrthoDB | EOG7SN8CD | |
| PhylomeDB | Q8CGN5 | |
| TreeFam | TF325901 | |
| Reactome | REACT_245618 REACT_252217 | |
| NextBio | 356265 | |
| PRO | PR:Q8CGN5 | |
| Proteomes | UP000000589 | |
| Bgee | Q8CGN5 | |
| CleanEx | MM_PLIN | |
| Genevestigator | Q8CGN5 | |
| GO | GO:0005829 GO:0005783 GO:0005811 GO:0016042 | |
| InterPro | IPR004279 | |
| PANTHER | PTHR14024 | |
| Pfam | PF03036 | |
| PIRSF | PIRSF036881 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045598 |
regulation of fat cell differentiation |
ECO:0000315 |
P |
Figure 3 shows that "Body weight gain of female hTg and mTg mice was similar to WT controls when fed a normal chow diet (ND) (data not shown). In contrast, when female mice were fed a HFD, both hTg and mTg mice gained weight less rapidly than their WT littermates (Fig. 3A, B). Male hTg mice had a very small but significant reduction in body weight gain when fed a HFD compared with WT littermates, whereas mTg did not differ from WT in their weight gain on an HFD. Since both female hTg and mTg mice demonstrated a more robust phenotype compared with male transgenic mice, the data presented throughout this manuscript focused only on female mice. At 30 weeks of age (25 weeks of HFD), both hTg and mTg mice weighed ~20% less than WT controls (Fig. 3A, B). The observed difference in body weight became significant after the animals reached 13 (hTg) and 22 (mTg) weeks of age, respectively. Regardless of diet, food intake was similar between Tg and WT mice and was not a contributing factor to the observed differences in body weight on the HFD (WT 2.28 ± 0.16g vs. 2.09 ± 0.09g, P = 0.55). In spite of their similar food consumption level, fasting serum leptin concentration was significantly lower in HFD-fed hTg mice compared with WT mice (9.83 ± 3.57 vs. 32.85 ± 0.02 ng/ml) (P = 0.003), which is probably explained by smaller adipocyte in hTg mice." |
complete | |||||
|
acts_upstream_of_or_within |
GO:0016042 |
lipid catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2176249 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16105) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005811 |
lipid droplet |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16105)|part_of:(CL:0000178) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005811 |
lipid droplet |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3351 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005811 |
lipid droplet |
Reactome:R-MMU-163511 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005811 |
lipid droplet |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Sutcliffe, JG & Milner, RJ (1988) Alternative mRNA splicing: the Shaker gene. Trends Genet. 4 297-9 PubMed GONUTS page
- ↑ Tansey, JT et al. (2001) Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. U.S.A. 98 6494-9 PubMed GONUTS page
- ↑ 3.0 3.1 Yamaguchi, T et al. (2006) MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 281 14232-40 PubMed GONUTS page
