MOUSE:PKD2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pkd2
Protein Name(s)	Polycystin-2 Polycystic kidney disease 2 protein homolog
External Links
UniProt	O35245
EMBL	AF014010 Y13278 Y14105 Y14106 Y14107 Y14108 Y14109 Y14110 Y14111 Y14112 Y14113 Y14114 Y14115 Y14116 Y14117 Y14118 Y14119 Y14120 FJ609779 AK053502 AC123687 AC124106 AF242389
CCDS	CCDS19487.1
RefSeq	NP_032887.3 XP_006534878.1
UniGene	Mm.483692 Mm.6442
ProteinModelPortal	O35245
SMR	O35245
BioGrid	202205
DIP	DIP-60904N
IntAct	O35245
PhosphoSite	O35245
MaxQB	O35245
PaxDb	O35245
PRIDE	O35245
Ensembl	ENSMUST00000086831
GeneID	18764
KEGG	mmu:18764
UCSC	uc012eab.1 uc012eac.1
CTD	5311
MGI	MGI:1099818
eggNOG	NOG325704
GeneTree	ENSGT00700000104221
HOGENOM	HOG000230858
HOVERGEN	HBG014945
InParanoid	O35245
KO	K04986
OMA	AWSRDNP
OrthoDB	EOG7N8ZTW
TreeFam	TF316484
ChiTaRS	Pkd2
NextBio	294963
PRO	PR:O35245
Proteomes	UP000000589
Bgee	O35245
CleanEx	MM_PKD2
Genevestigator	O35245
GO	GO:0045180 GO:0009925 GO:0036064 GO:0060170 GO:0005929 GO:0005737 GO:0005783 GO:0070062 GO:0031941 GO:0071458 GO:0071556 GO:0005887 GO:0030027 GO:0072686 GO:0031512 GO:0031513 GO:0005886 GO:0002133 GO:0051117 GO:0005262 GO:0005509 GO:0048763 GO:0015267 GO:0042802 GO:0005267 GO:0005102 GO:0005245 GO:0005248 GO:0035904 GO:0001658 GO:0006816 GO:0007050 GO:0006874 GO:0071498 GO:0071464 GO:0071470 GO:0042994 GO:0050982 GO:0003127 GO:0007368 GO:0071910 GO:0001892 GO:0007507 GO:0001947 GO:0007259 GO:0001822 GO:0001889 GO:0072177 GO:0072218 GO:0072214 GO:0072219 GO:0072235 GO:0072075 GO:0035502 GO:0072284 GO:0072208 GO:2000134 GO:0060315 GO:0021915 GO:0060674 GO:0071158 GO:0031659 GO:0010628 GO:0031587 GO:0045429 GO:0045944 GO:0071805 GO:0090279 GO:0030814 GO:0042127 GO:0051209 GO:0061441 GO:0072001 GO:0061333 GO:0021510
Gene3D	1.10.238.10 1.20.120.350
InterPro	IPR027359 IPR011992 IPR002048 IPR013122 IPR003915
Pfam	PF08016
PRINTS	PR01433
PROSITE	PS50222

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004672	protein kinase activity	PMID:22311617^[1]	ECO:0000269			F		Figure 3 shows 'in vitro migration and in vivo trafficking of WT and PKD2-deficient lymphocytes to secondary lymphoid tissues.'	complete CACAO 5896
	GO:0004672	protein kinase activity	PMID:22233340^[2]	ECO:0000314			F		Figure 1 shows that 'PKD2 regulates thymic output.'	complete CACAO 5898
	GO:0004672	protein kinase activity	PMID:22233340^[2]	ECO:0000314			F		Figure 5 shows the 'role of PKD2 in thymus development of TCR transgenic mice.'	complete CACAO 5900
involved_in	GO:0051262	protein tetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
part_of	GO:0034703	cation channel complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
part_of	GO:0002133	polycystin complex	PMID:25405894^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:25405894^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:25405894^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:25405894^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0198738	cell-cell signaling by wnt	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:27760766^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:27760766^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:27760766^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:27760766^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	PMID:27760766^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0015271	outward rectifier potassium channel activity	PMID:27760766^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	PMID:15123714^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	PMID:19265036^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060674	placenta blood vessel development	PMID:20862291^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:19265036^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:19265036^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045180	basal cortex	PMID:10770959^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20408813^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35245	F		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21307093^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19265036^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005911	cell-cell junction	PMID:15843396^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10770959^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:20408813^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003127	detection of nodal flow	PMID:21307093^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001892	embryonic placenta development	PMID:20862291^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061333	renal tubule morphogenesis	PMID:20181743^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20181743^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050982	detection of mechanical stimulus	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1099818 PANTHER:PTN000093539 UniProtKB:E7FKV8 UniProtKB:H2LRU7	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000093539 RGD:1559992 UniProtKB:Q9P0L9 WB:WBGene00004035	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1099818 MGI:MGI:1352448 PANTHER:PTN000093539 UniProtKB:Q8TDX9 UniProtKB:Q9P0L9 WB:WBGene00004035	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0198738	cell-cell signaling by wnt	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098662	inorganic cation transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
part_of	GO:0097730	non-motile cilium	PMID:12062067^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090279	regulation of calcium ion import	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071910	determination of liver left/right asymmetry	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071805	potassium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
part_of	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071498	cellular response to fluid shear stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071470	cellular response to osmotic stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071464	cellular response to hydrostatic pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
part_of	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071320	cellular response to cAMP	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071158	positive regulation of cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070588	calcium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	PMID:17404231^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051393	alpha-actinin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1559992	F		Seeded From UniProt	complete
enables	GO:0051371	muscle alpha-actinin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1559992	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051290	protein heterotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051289	protein homotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051262	protein tetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051209	release of sequestered calcium ion into cytosol	PMID:17404231^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860866	P	occurs_in:(EMAPA:16105) occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	PMID:18178578^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01853	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050982	detection of mechanical stimulus	PMID:12514735^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17373) occurs_in:(CL:0000067)	Seeded From UniProt	complete
enables	GO:0048763	calcium-induced calcium release activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
part_of	GO:0045180	basal cortex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044782	cilium organization	PMID:28154160^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
enables	GO:0043398	HLH domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042994	cytoplasmic sequestering of transcription factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
enables	GO:0042805	actinin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:22031837^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17168) part_of:(CL:0010009)	Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035725	sodium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
part_of	GO:0034703	cation channel complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
colocalizes_with	GO:0031941	filamentous actin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	PMID:15858826^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17962) part_of:(CL:0000501)\|part_of:(EMAPA:29043) part_of:(CL:0000501)	Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
enables	GO:0022843	voltage-gated cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1559992	C		Seeded From UniProt	complete
enables	GO:0015267	channel activity	PMID:18235088^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860840	F		Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:10615132^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:12062060^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2676373	P	has_participant:(EMAPA:16105)\|has_participant:(EMAPA:16728)\|has_participant:(EMAPA:18889)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007259	receptor signaling pathway via JAK-STAT	PMID:12007403^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1559992	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	PMID:12007403^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	PMID:12874107^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:12514735^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17373) occurs_in:(CL:0000067)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:28154160^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21685914^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:18552856^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:16316413^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16075) part_of:(CL:0000064)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:12640140^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:12514735^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17373) part_of:(CL:0000067)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:28154160^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12640140^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:12640140^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:16192288^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:28154160^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1559992	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
enables	GO:0005267	potassium channel activity	PMID:12640140^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005267	potassium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:12640140^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0005262	calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
enables	GO:0005248	voltage-gated sodium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:17404231^[15]	ECO:0000353	physical interaction evidence used in manual assertion	RefSeq:NP_076357	F	occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
part_of	GO:0002133	polycystin complex	PMID:11901144^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001947	heart looping	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13563	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001892	embryonic placenta development	PMID:16301212^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860840	P	results_in_development_of:(EMAPA:35689)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001889	liver development	PMID:21685914^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:21685914^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:10615132^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860866	P		Seeded From UniProt	complete
enables	GO:0051393	alpha-actinin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A5F1 ensembl:ENSRNOP00000002916	F		Seeded From UniProt	complete
enables	GO:0051371	muscle alpha-actinin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A5F1 ensembl:ENSRNOP00000002916	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A5F1 ensembl:ENSRNOP00000002916	C		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A5F1 ensembl:ENSRNOP00000002916	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A5F1 ensembl:ENSRNOP00000002916	C		Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0198738	cell-cell signaling by wnt	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0098662	inorganic cation transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0090279	regulation of calcium ion import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
involved_in	GO:0072284	metanephric S-shaped body morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0072235	metanephric distal tubule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0072219	metanephric cortical collecting duct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0072218	metanephric ascending thin limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0072214	metanephric cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0072208	metanephric smooth muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0072177	mesonephric duct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0072164	mesonephric tubule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0072075	metanephric mesenchyme development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0071910	determination of liver left/right asymmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
part_of	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0071470	cellular response to osmotic stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0071464	cellular response to hydrostatic pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
part_of	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0071158	positive regulation of cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0061441	renal artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
enables	GO:0048763	calcium-induced calcium release activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
part_of	GO:0045180	basal cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
involved_in	GO:0044782	cilium organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
enables	GO:0043398	HLH domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
involved_in	GO:0042994	cytoplasmic sequestering of transcription factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
enables	GO:0042805	actinin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
involved_in	GO:0035904	aorta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0035502	metanephric part of ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
part_of	GO:0034703	cation channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
part_of	GO:0031941	filamentous actin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
involved_in	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
enables	GO:0022843	voltage-gated cation channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0021510	spinal cord development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
enables	GO:0005267	potassium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
enables	GO:0005248	voltage-gated sodium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	F		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13563 ensembl:ENSP00000237596	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048 InterPro:IPR003915	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003915	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:10913159^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:12007403^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0633	P		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	P		Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0005267	potassium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	F		Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0305	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0026	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Matthews, SA et al. (2012) Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues. Eur. J. Immunol. 42 1316-26 PubMed GONUTS page
↑ ^2.0 ^2.1 Navarro, MN et al. (2012) Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells. Biochem. J. 442 649-59 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Kim, H et al. (2014) Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism. Nat Commun 5 5482 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Kleene, SJ & Kleene, NK (2017) The native TRPP2-dependent channel of murine renal primary cilia. Am. J. Physiol. Renal Physiol. 312 F96-F108 PubMed GONUTS page
↑ Rundle, DR et al. (2004) PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles. J. Biol. Chem. 279 29728-39 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 AbouAlaiwi, WA et al. (2009) Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. Circ. Res. 104 860-9 PubMed GONUTS page
↑ ^7.0 ^7.1 Garcia-Gonzalez, MA et al. (2010) Pkd1 and Pkd2 are required for normal placental development. PLoS ONE 5 PubMed GONUTS page
↑ ^8.0 ^8.1 Foggensteiner, L et al. (2000) Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene. J. Am. Soc. Nephrol. 11 814-27 PubMed GONUTS page
↑ ^9.0 ^9.1 Molland, KL et al. (2010) Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2. Biochem. J. 429 171-83 PubMed GONUTS page
↑ ^10.0 ^10.1 Field, S et al. (2011) Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2. Development 138 1131-42 PubMed GONUTS page
↑ Li, Q et al. (2005) Alpha-actinin associates with polycystin-2 and regulates its channel activity. Hum. Mol. Genet. 14 1587-603 PubMed GONUTS page
↑ ^12.0 ^12.1 Xia, S et al. (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137 1075-84 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Pazour, GJ et al. (2002) Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr. Biol. 12 R378-80 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Anyatonwu, GI et al. (2007) Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc. Natl. Acad. Sci. U.S.A. 104 6454-9 PubMed GONUTS page
↑ Liang, G et al. (2008) Polycystin-2 is regulated by endoplasmic reticulum-associated degradation. Hum. Mol. Genet. 17 1109-19 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Nauli, SM et al. (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet. 33 129-37 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
↑ Mühlhans, J et al. (2011) The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors. PLoS ONE 6 e26496 PubMed GONUTS page
↑ Teilmann, SC et al. (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol. Reprod. Dev. 71 444-52 PubMed GONUTS page
↑ Kim, I et al. (2008) Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. J. Am. Soc. Nephrol. 19 455-68 PubMed GONUTS page
↑ ^22.0 ^22.1 Wu, G et al. (2000) Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat. Genet. 24 75-8 PubMed GONUTS page
↑ Pennekamp, P et al. (2002) The ion channel polycystin-2 is required for left-right axis determination in mice. Curr. Biol. 12 938-43 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Bhunia, AK et al. (2002) PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 109 157-68 PubMed GONUTS page
↑ Qian, Q et al. (2003) Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells. Hum. Mol. Genet. 12 1875-80 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Fedeles, SV et al. (2011) A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nat. Genet. 43 639-47 PubMed GONUTS page
↑ Li, X et al. (2008) A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease. Nat. Med. 14 863-8 PubMed GONUTS page
↑ Karcher, C et al. (2005) Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia. Differentiation 73 425-32 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 ^29.4 Luo, Y et al. (2003) Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol. Cell. Biol. 23 2600-7 PubMed GONUTS page
↑ Hackmann, K et al. (2005) A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1. Hum. Mol. Genet. 14 3249-62 PubMed GONUTS page
↑ Newby, LJ et al. (2002) Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex. J. Biol. Chem. 277 20763-73 PubMed GONUTS page
↑ Allen, E et al. (2006) Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors. Hum. Mol. Genet. 15 11-21 PubMed GONUTS page
↑ Lehtonen, S et al. (2000) In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2. J. Biol. Chem. 275 32888-93 PubMed GONUTS page

[PMID:22311617-1] Matthews, SA et al. (2012) Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues. Eur. J. Immunol. 42 1316-26 PubMed GONUTS page

[PMID:22233340-2] 2.0 ^2.1 Navarro, MN et al. (2012) Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells. Biochem. J. 442 649-59 PubMed GONUTS page

[PMID:25405894-3] 3.0 ^3.1 ^3.2 ^3.3 Kim, H et al. (2014) Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism. Nat Commun 5 5482 PubMed GONUTS page

[PMID:27760766-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Kleene, SJ & Kleene, NK (2017) The native TRPP2-dependent channel of murine renal primary cilia. Am. J. Physiol. Renal Physiol. 312 F96-F108 PubMed GONUTS page

[PMID:15123714-5] Rundle, DR et al. (2004) PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles. J. Biol. Chem. 279 29728-39 PubMed GONUTS page

[PMID:19265036-6] 6.0 ^6.1 ^6.2 ^6.3 AbouAlaiwi, WA et al. (2009) Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. Circ. Res. 104 860-9 PubMed GONUTS page

[PMID:20862291-7] 7.0 ^7.1 Garcia-Gonzalez, MA et al. (2010) Pkd1 and Pkd2 are required for normal placental development. PLoS ONE 5 PubMed GONUTS page

[PMID:10770959-8] 8.0 ^8.1 Foggensteiner, L et al. (2000) Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene. J. Am. Soc. Nephrol. 11 814-27 PubMed GONUTS page

[PMID:20408813-9] 9.0 ^9.1 Molland, KL et al. (2010) Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2. Biochem. J. 429 171-83 PubMed GONUTS page

[PMID:21307093-10] 10.0 ^10.1 Field, S et al. (2011) Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2. Development 138 1131-42 PubMed GONUTS page

[PMID:15843396-11] Li, Q et al. (2005) Alpha-actinin associates with polycystin-2 and regulates its channel activity. Hum. Mol. Genet. 14 1587-603 PubMed GONUTS page

[PMID:20181743-12] 12.0 ^12.1 Xia, S et al. (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137 1075-84 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12062067-14] Pazour, GJ et al. (2002) Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr. Biol. 12 R378-80 PubMed GONUTS page

[PMID:17404231-15] 15.0 ^15.1 ^15.2 Anyatonwu, GI et al. (2007) Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc. Natl. Acad. Sci. U.S.A. 104 6454-9 PubMed GONUTS page

[PMID:18178578-16] Liang, G et al. (2008) Polycystin-2 is regulated by endoplasmic reticulum-associated degradation. Hum. Mol. Genet. 17 1109-19 PubMed GONUTS page

[PMID:12514735-17] 17.0 ^17.1 ^17.2 Nauli, SM et al. (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet. 33 129-37 PubMed GONUTS page

[PMID:28154160-18] 18.0 ^18.1 ^18.2 ^18.3 Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page

[PMID:22031837-19] Mühlhans, J et al. (2011) The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors. PLoS ONE 6 e26496 PubMed GONUTS page

[PMID:15858826-20] Teilmann, SC et al. (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol. Reprod. Dev. 71 444-52 PubMed GONUTS page

[PMID:18235088-21] Kim, I et al. (2008) Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. J. Am. Soc. Nephrol. 19 455-68 PubMed GONUTS page

[PMID:10615132-22] 22.0 ^22.1 Wu, G et al. (2000) Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat. Genet. 24 75-8 PubMed GONUTS page

[PMID:12062060-23] Pennekamp, P et al. (2002) The ion channel polycystin-2 is required for left-right axis determination in mice. Curr. Biol. 12 938-43 PubMed GONUTS page

[PMID:12007403-24] 24.0 ^24.1 ^24.2 Bhunia, AK et al. (2002) PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 109 157-68 PubMed GONUTS page

[PMID:12874107-25] Qian, Q et al. (2003) Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells. Hum. Mol. Genet. 12 1875-80 PubMed GONUTS page

[PMID:21685914-26] 26.0 ^26.1 ^26.2 Fedeles, SV et al. (2011) A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nat. Genet. 43 639-47 PubMed GONUTS page

[PMID:18552856-27] Li, X et al. (2008) A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease. Nat. Med. 14 863-8 PubMed GONUTS page

[PMID:16316413-28] Karcher, C et al. (2005) Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia. Differentiation 73 425-32 PubMed GONUTS page

[PMID:12640140-29] 29.0 ^29.1 ^29.2 ^29.3 ^29.4 Luo, Y et al. (2003) Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol. Cell. Biol. 23 2600-7 PubMed GONUTS page

[PMID:16192288-30] Hackmann, K et al. (2005) A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1. Hum. Mol. Genet. 14 3249-62 PubMed GONUTS page

[PMID:11901144-31] Newby, LJ et al. (2002) Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex. J. Biol. Chem. 277 20763-73 PubMed GONUTS page

[PMID:16301212-32] Allen, E et al. (2006) Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors. Hum. Mol. Genet. 15 11-21 PubMed GONUTS page

[PMID:10913159-33] Lehtonen, S et al. (2000) In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2. J. Biol. Chem. 275 32888-93 PubMed GONUTS page

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