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MOUSE:PH4H
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Pah | |
| Protein Name(s) | Phenylalanine-4-hydroxylase
PAH Phe-4-monooxygenase | |
| External Links | ||
| UniProt | P16331 | |
| EMBL | X51942 AC122360 BC013458 | |
| CCDS | CCDS24102.1 | |
| PIR | S15758 | |
| RefSeq | NP_032803.2 | |
| UniGene | Mm.263539 | |
| ProteinModelPortal | P16331 | |
| SMR | P16331 | |
| IntAct | P16331 | |
| MINT | MINT-1855311 | |
| STRING | 10090.ENSMUSP00000020241 | |
| PhosphoSite | P16331 | |
| MaxQB | P16331 | |
| PaxDb | P16331 | |
| PRIDE | P16331 | |
| Ensembl | ENSMUST00000020241 | |
| GeneID | 18478 | |
| KEGG | mmu:18478 | |
| UCSC | uc007gqt.2 | |
| CTD | 5053 | |
| MGI | MGI:97473 | |
| eggNOG | COG3186 | |
| GeneTree | ENSGT00390000010268 | |
| HOGENOM | HOG000233373 | |
| HOVERGEN | HBG006841 | |
| InParanoid | P16331 | |
| KO | K00500 | |
| OMA | TITEFQP | |
| OrthoDB | EOG7KM5T1 | |
| TreeFam | TF313327 | |
| Reactome | REACT_189094 REACT_261966 | |
| UniPathway | UPA00139 | |
| ChiTaRS | Pah | |
| NextBio | 294182 | |
| PRO | PR:P16331 | |
| Proteomes | UP000000589 | |
| Bgee | P16331 | |
| CleanEx | MM_PAH | |
| ExpressionAtlas | P16331 | |
| Genevestigator | P16331 | |
| GO | GO:0070062 GO:0016597 GO:0005506 GO:0004505 GO:0006559 | |
| Gene3D | 1.10.800.10 | |
| InterPro | IPR002912 IPR001273 IPR018301 IPR019774 IPR005961 IPR019773 | |
| PANTHER | PTHR11473 | |
| Pfam | PF01842 PF00351 | |
| PIRSF | PIRSF000336 | |
| PRINTS | PR00372 | |
| SUPFAM | SSF56534 | |
| TIGRFAMs | TIGR01268 | |
| PROSITE | PS51671 PS00367 PS51410 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006571 |
tyrosine biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000895564 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004505 |
phenylalanine 4-monooxygenase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001208 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048037 |
cofactor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3248 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046146 |
tetrahydrobiopterin metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3248 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3248 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042558 |
pteridine-containing compound metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3248 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0018126 |
protein hydroxylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3248 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016597 |
amino acid binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3248 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006571 |
tyrosine biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3248 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006558 |
L-phenylalanine metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3248 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005506 |
iron ion binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3248 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004505 |
phenylalanine 4-monooxygenase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857271 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004505 |
phenylalanine 4-monooxygenase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004505 |
phenylalanine 4-monooxygenase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3248 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004505 |
phenylalanine 4-monooxygenase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P00439 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004505 |
phenylalanine 4-monooxygenase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005506 |
iron ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006559 |
L-phenylalanine catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009072 |
aromatic amino acid family metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016714 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001273 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004505 |
phenylalanine 4-monooxygenase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006559 |
L-phenylalanine catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0585 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ McDonald, JD et al. (1990) Pahhph-5: a mouse mutant deficient in phenylalanine hydroxylase. Proc. Natl. Acad. Sci. U.S.A. 87 1965-7 PubMed GONUTS page
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- GO:0048037 ! obsolete cofactor binding
- GO:0055114 ! obsolete oxidation-reduction process
- GO:0016491 ! oxidoreductase activity
- GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
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