GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:PGAM5
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Pgam5 | |
| Protein Name(s) | Serine/threonine-protein phosphatase PGAM5, mitochondrial
Phosphoglycerate mutase family member 5 | |
| External Links | ||
| UniProt | Q8BX10 | |
| EMBL | AK012159 AK034588 AK049246 AK146216 AK169643 BC052179 BC138924 BC138925 | |
| CCDS | CCDS19523.1 CCDS51606.1 | |
| RefSeq | NP_001157010.1 NP_082549.2 | |
| UniGene | Mm.61682 | |
| ProteinModelPortal | Q8BX10 | |
| SMR | Q8BX10 | |
| BioGrid | 215426 | |
| DIP | DIP-32064N | |
| IntAct | Q8BX10 | |
| ChEMBL | CHEMBL2331071 | |
| PhosphoSite | Q8BX10 | |
| MaxQB | Q8BX10 | |
| PaxDb | Q8BX10 | |
| PRIDE | Q8BX10 | |
| Ensembl | ENSMUST00000059229 ENSMUST00000112505 | |
| GeneID | 72542 | |
| KEGG | mmu:72542 | |
| UCSC | uc008yqh.2 uc008yqi.2 | |
| CTD | 192111 | |
| MGI | MGI:1919792 | |
| eggNOG | NOG71348 | |
| GeneTree | ENSGT00390000004796 | |
| HOGENOM | HOG000261217 | |
| HOVERGEN | HBG105576 | |
| InParanoid | Q8BX10 | |
| KO | K15637 | |
| OMA | EIIVCHA | |
| OrthoDB | EOG7966H1 | |
| PhylomeDB | Q8BX10 | |
| TreeFam | TF314977 | |
| ChiTaRS | Pgam5 | |
| NextBio | 336451 | |
| PRO | PR:Q8BX10 | |
| Proteomes | UP000000589 | |
| Bgee | Q8BX10 | |
| CleanEx | MM_PGAM5 | |
| Genevestigator | Q8BX10 | |
| GO | GO:0016021 GO:0005741 GO:0005096 GO:0016791 GO:0004721 GO:0016311 GO:0070266 GO:0043547 | |
| Gene3D | 3.40.50.1240 | |
| InterPro | IPR013078 IPR029033 | |
| Pfam | PF00300 | |
| SMART | SM00855 | |
| SUPFAM | SSF53254 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005739 |
mitochondrion |
ECO:0000314 |
C |
Fig. 6A |
complete | |||||
| GO:0043065 |
positive regulation of apoptosis |
ECO:0000315 |
P |
Fig. 9B |
complete | |||||
| GO:0070585 |
protein localization in mitochondrion |
ECO:0000315 |
P |
Fig. 6B |
complete | |||||
|
involved_in |
GO:0120163 |
negative regulation of cold-induced thermogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070266 |
necroptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016791 |
phosphatase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070266 |
necroptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016791 |
phosphatase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004722 |
protein serine/threonine phosphatase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004722 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004722 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004721 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070266 |
necroptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96HS1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96HS1 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016791 |
phosphatase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96HS1 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96HS1 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96HS1 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004722 |
protein serine/threonine phosphatase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96HS1 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0012501 |
programmed cell death |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Niture, SK & Jaiswal, AK (2011) Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J. Biol. Chem. 286 44542-56 PubMed GONUTS page
- ↑ Sekine, S et al. (2016) The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress. EBioMedicine 5 82-92 PubMed GONUTS page
- ↑ Wang, Z et al. (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148 228-43 PubMed GONUTS page
m
p
- GO:0016791 ! phosphatase activity
- GO:0004721 ! phosphoprotein phosphatase activity
- GO:0043547 ! positive regulation of GTPase activity
- GO:0043065 ! positive regulation of apoptotic process
- GO:0012501 ! programmed cell death
- GO:0044877 ! protein-containing complex binding
- GO:0006470 ! protein dephosphorylation
- GO:0070585 ! protein localization to mitochondrion
- GO:0004722 ! protein serine/threonine phosphatase activity
r
