MOUSE:PDGFA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pdgfa
Protein Name(s)	Platelet-derived growth factor subunit A PDGF subunit A PDGF-1 Platelet-derived growth factor A chain Platelet-derived growth factor alpha polypeptide
External Links
UniProt	P20033
EMBL	S66873 S66868 S66869 S66870 S66871 S66872 S66874 S66868 S66869 S66870 S66871 S66872 M29464
CCDS	CCDS19802.1
PIR	A37359
RefSeq	NP_032834.1
UniGene	Mm.2675
ProteinModelPortal	P20033
SMR	P20033
PhosphoSite	P20033
PaxDb	P20033
PRIDE	P20033
GeneID	18590
KEGG	mmu:18590
CTD	5154
MGI	MGI:97527
eggNOG	NOG75094
HOGENOM	HOG000286027
HOVERGEN	HBG053546
InParanoid	P20033
KO	K04359
PhylomeDB	P20033
NextBio	294472
PRO	PR:P20033
Proteomes	UP000000589
CleanEx	MM_PDGFA
Genevestigator	P20033
GO	GO:0009986 GO:0005615 GO:0016020 GO:0005902 GO:0005518 GO:0008083 GO:0005161 GO:0042803 GO:0030036 GO:0001525 GO:0007596 GO:0030031 GO:0048565 GO:1990401 GO:0001942 GO:0048286 GO:0050919 GO:0010512 GO:0010544 GO:0009887 GO:0048008 GO:0051781 GO:0030335 GO:0008284 GO:0045740 GO:0070374 GO:0048146 GO:0043406 GO:0043410 GO:0002053 GO:0035793 GO:0014068 GO:0031954 GO:0051897 GO:0060683 GO:0050730 GO:0014910 GO:0009611 GO:0043588
Gene3D	2.10.90.10
InterPro	IPR029034 IPR023581 IPR000072 IPR006782
Pfam	PF00341 PF04692
SMART	SM00141
SUPFAM	SSF57501
PROSITE	PS00249 PS50278

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048286	lung alveolus development	PMID:23938297^[1]	ECO:0000315			P		Figure 4 - Concentration of PDGF-A is critical for development and maintenance of alveolar structure.	complete CACAO 8895
involved_in	GO:0048286	lung alveolus development	PMID:23938297^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990401	embryonic lung development	PMID:9374392^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19734317^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|involved_in	GO:2000278	regulation of DNA biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0072124	regulation of glomerular mesangial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0050919	negative chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	PMID:10903171^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048286	lung alveolus development	PMID:9374392^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	F		Seeded From UniProt	complete
involved_in	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0014910	regulation of smooth muscle cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0010544	negative regulation of platelet activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0010512	negative regulation of phosphatidylinositol biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	C		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	F		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	F		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04085	F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000180420 UniProtKB:P01127 UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859631 PANTHER:PTN000180420 RGD:3283 UniProtKB:P01127 UniProtKB:P04085 UniProtKB:Q9NRA1	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000180420 RGD:3283 UniProtKB:P01127 UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000908679 UniProtKB:P01127 UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97528 PANTHER:PTN000180420 UniProtKB:B1H0W5 UniProtKB:P01127 UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97528 PANTHER:PTN000180420 UniProtKB:P01127 UniProtKB:P04085	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859631 MGI:MGI:97527 PANTHER:PTN000908679 RGD:3282 UniProtKB:P01127 UniProtKB:P04085 UniProtKB:Q9NRA1	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97527 PANTHER:PTN000908679 RGD:3283 RGD:621880 UniProtKB:P04085 UniProtKB:Q9NRA1	C		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859631 PANTHER:PTN000180420 UniProtKB:P01127 UniProtKB:P04085 UniProtKB:Q9NRA1	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060683	regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	PMID:18559345^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_has_participant:(EMAPA:17755) regulates_o_has_participant:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060348	bone development	PMID:23938297^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1859631	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050919	negative chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	PMID:11940581^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048565	digestive tract development	PMID:23938297^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1859631	P		Seeded From UniProt	complete
enables	GO:0048407	platelet-derived growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048286	lung alveolus development	PMID:23938297^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5548172	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048286	lung alveolus development	PMID:11803579^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926817	P	results_in_development_of:(EMAPA:35433)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043588	skin development	PMID:10331973^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926817	P	results_in_development_of:(EMAPA:17527)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031954	positive regulation of protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030036	actin cytoskeleton organization	PMID:12176888^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030031	cell projection assembly	PMID:12176888^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014910	regulation of smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010544	negative regulation of platelet activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010512	negative regulation of phosphatidylinositol biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:15361870^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1859631	P	has_participant:(EMAPA:18948)\|has_participant:(EMAPA:36437)\|has_participant:(EMAPA:17333)\|has_participant:(EMAPA:17011)\|has_participant:(EMAPA:16681)\|has_participant:(EMAPA:17678)\|has_participant:(EMAPA:18343)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:14522834^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926817	P	has_participant:(EMAPA:19290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009611	response to wounding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:10331973^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926817	P	regulates_o_occurs_in:(EMAPA:17527)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3282	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	F		Seeded From UniProt	complete
part_of	GO:0005902	microvillus	PMID:12101409^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	F		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04085	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002053	positive regulation of mesenchymal cell proliferation	PMID:10331973^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926817	P	occurs_in:(EMAPA:17525)\|occurs_in:(EMAPA:18771)\|occurs_in:(EMAPA:17527)\|occurs_in:(EMAPA:35282)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001942	hair follicle development	PMID:10331973^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926817	P	results_in_development_of:(EMAPA:18771)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:12101409^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000072 InterPro:IPR006782	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000072 InterPro:IPR006782	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Andrae, J et al. (2013) Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A. Mol. Cell. Biol. 33 4030-40 PubMed GONUTS page
↑ ^2.0 ^2.1 Lindahl, P et al. (1997) Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Development 124 3943-53 PubMed GONUTS page
↑ Salazar, KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 297 L1002-11 PubMed GONUTS page
↑ Karlsson, L et al. (2000) Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development 127 3457-66 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yamamoto, S et al. (2008) Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J. Biol. Chem. 283 23139-49 PubMed GONUTS page
↑ Saito, Y et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J. Biol. Chem. 277 23216-22 PubMed GONUTS page
↑ Boström, H et al. (2002) PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. Dev. Dyn. 223 155-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Karlsson, L et al. (1999) Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development 126 2611-21 PubMed GONUTS page
↑ ^10.0 ^10.1 Tao, W et al. (2002) The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization. Blood 100 1679-88 PubMed GONUTS page
↑ Ding, H et al. (2004) A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat. Genet. 36 1111-6 PubMed GONUTS page
↑ Basciani, S et al. (2004) Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor beta deficient mice. Biol. Reprod. 70 168-77 PubMed GONUTS page
↑ ^13.0 ^13.1 Shindo, T et al. (2002) Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat. Med. 8 856-63 PubMed GONUTS page

[PMID:23938297-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Andrae, J et al. (2013) Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A. Mol. Cell. Biol. 33 4030-40 PubMed GONUTS page

[PMID:9374392-2] 2.0 ^2.1 Lindahl, P et al. (1997) Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Development 124 3943-53 PubMed GONUTS page

[PMID:19734317-3] Salazar, KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 297 L1002-11 PubMed GONUTS page

[PMID:10903171-4] Karlsson, L et al. (2000) Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development 127 3457-66 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18559345-6] Yamamoto, S et al. (2008) Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J. Biol. Chem. 283 23139-49 PubMed GONUTS page

[PMID:11940581-7] Saito, Y et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J. Biol. Chem. 277 23216-22 PubMed GONUTS page

[PMID:11803579-8] Boström, H et al. (2002) PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. Dev. Dyn. 223 155-62 PubMed GONUTS page

[PMID:10331973-9] 9.0 ^9.1 ^9.2 ^9.3 Karlsson, L et al. (1999) Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development 126 2611-21 PubMed GONUTS page

[PMID:12176888-10] 10.0 ^10.1 Tao, W et al. (2002) The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization. Blood 100 1679-88 PubMed GONUTS page

[PMID:15361870-11] Ding, H et al. (2004) A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat. Genet. 36 1111-6 PubMed GONUTS page

[PMID:14522834-12] Basciani, S et al. (2004) Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor beta deficient mice. Biol. Reprod. 70 168-77 PubMed GONUTS page

[PMID:12101409-13] 13.0 ^13.1 Shindo, T et al. (2002) Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat. Med. 8 856-63 PubMed GONUTS page

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MOUSE:PDGFA

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