GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

MOUSE:PDE5A

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Pde5a (synonyms: Pde5)
Protein Name(s) cGMP-specific 3',5'-cyclic phosphodiesterase

cGMP-binding cGMP-specific phosphodiesterase CGB-PDE

External Links
UniProt Q8CG03
EMBL AF541937
CH466532
BC119137
BC120486
CCDS CCDS17812.1
RefSeq NP_700471.2
UniGene Mm.134911
PDB 2K31
PDBsum 2K31
ProteinModelPortal Q8CG03
SMR Q8CG03
IntAct Q8CG03
MINT MINT-4106875
PhosphoSite Q8CG03
MaxQB Q8CG03
PaxDb Q8CG03
PRIDE Q8CG03
Ensembl ENSMUST00000066728
GeneID 242202
KEGG mmu:242202
UCSC uc008ret.2
CTD 8654
MGI MGI:2651499
eggNOG NOG270709
GeneTree ENSGT00760000119066
HOGENOM HOG000007068
HOVERGEN HBG101207
InParanoid Q8CG03
KO K13762
OMA REHDANK
OrthoDB EOG7RRF69
TreeFam TF316499
Reactome REACT_229620
UniPathway UPA00763
ChiTaRS Pde5a
EvolutionaryTrace Q8CG03
NextBio 385258
PRO PR:Q8CG03
Proteomes UP000000589
Bgee Q8CG03
CleanEx MM_PDE5A
Genevestigator Q8CG03
GO GO:0047555
GO:0004114
GO:0030553
GO:0004112
GO:0046872
GO:0046069
GO:0046068
GO:0055118
GO:0042130
GO:0010613
GO:0045745
GO:0043406
GO:0060282
GO:0030823
GO:0055119
GO:0007165
Gene3D 1.10.1300.10
3.30.450.40
InterPro IPR003018
IPR029016
IPR003607
IPR023088
IPR002073
IPR023174
Pfam PF01590
PF00233
PRINTS PR00387
SMART SM00065
SM00471
SUPFAM SSF55781
PROSITE PS00126

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0010613

positive regulation of cardiac muscle hypertrophy

PMID:19127022[1]

ECO:0000269

P

Figure 5: PDE5 inhibitor reduced hypertrophy in RGS2 +/+ mice. Not seen in RGS2 -/- mice which shows connection between RGS2 and PDE5 in cardiac regulatory pathways.

complete

GO:0055117

regulation of cardiac muscle contraction

PMID:19127022[1]

ECO:0000269

P

Figure 5F: Upon treatment with PDE5 inhibitor an improvement in systolic and diastolic function was observed in TAC treated hearts. Not seen in RGS2 -/- - due to connection between RGS2 and PDE5

complete

involved_in

GO:0055119

relaxation of cardiac muscle

PMID:19127022[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055118

negative regulation of cardiac muscle contraction

PMID:19127022[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045745

positive regulation of G protein-coupled receptor signaling pathway

PMID:19127022[1]

ECO:0000305

curator inference used in manual assertion

GO:0043406

P

Seeded From UniProt

complete

involved_in

GO:0043406

positive regulation of MAP kinase activity

PMID:19127022[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010613

positive regulation of cardiac muscle hypertrophy

PMID:19127022[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0047555

3',5'-cyclic-GMP phosphodiesterase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002602903
RGD:620995
UniProtKB:O76074

F

Seeded From UniProt

complete

enables

GO:0030553

cGMP binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2651499
PANTHER:PTN002602903

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002026

regulation of the force of heart contraction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620995

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060282

positive regulation of oocyte development

PMID:19474061[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1860764

P

  • regulates_o_occurs_in:(EMAPA:17962)
  • regulates_o_results_in_development_of:(CL:0000024)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060282

positive regulation of oocyte development

PMID:19474061[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:17962)
  • regulates_o_results_in_development_of:(CL:0000023)

Seeded From UniProt

complete

enables

GO:0047555

3',5'-cyclic-GMP phosphodiesterase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O76074

F

Seeded From UniProt

complete

enables

GO:0047555

3',5'-cyclic-GMP phosphodiesterase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620995

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046069

cGMP catabolic process

PMID:12554648[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046068

cGMP metabolic process

PMID:20511540[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(EMAPA:16728)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046068

cGMP metabolic process

PMID:19474061[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(EMAPA:17962)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045907

positive regulation of vasoconstriction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620995

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620995

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042130

negative regulation of T cell proliferation

PMID:17101732[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030553

cGMP binding

PMID:18534985[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030553

cGMP binding

PMID:12554648[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010749

regulation of nitric oxide mediated signal transduction

PMID:16150726[8]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2446107

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007614

short-term memory

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620995

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620995

C

Seeded From UniProt

complete

enables

GO:0004114

3',5'-cyclic-nucleotide phosphodiesterase activity

PMID:19474061[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

occurs_in:(EMAPA:17962)

Seeded From UniProt

complete

enables

GO:0004112

cyclic-nucleotide phosphodiesterase activity

PMID:12554648[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002678

positive regulation of chronic inflammatory response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620995

P

Seeded From UniProt

complete

enables

GO:0047555

3',5'-cyclic-GMP phosphodiesterase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O76074
ensembl:ENSP00000347046

F

Seeded From UniProt

complete

enables

GO:0004114

3',5'-cyclic-nucleotide phosphodiesterase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002073
InterPro:IPR036971

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002073
InterPro:IPR036971

P

Seeded From UniProt

complete

enables

GO:0008081

phosphoric diester hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR023088
InterPro:IPR023174

F

Seeded From UniProt

complete

enables

GO:0047555

3',5'-cyclic-GMP phosphodiesterase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.4.35

F

Seeded From UniProt

complete

enables

GO:0030553

cGMP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0142

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0046069

cGMP catabolic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00763

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Takimoto, E et al. (2009) Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J. Clin. Invest. 119 408-20 PubMed GONUTS page
  2. ↑ 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Vaccari, S et al. (2009) Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes. Biol. Reprod. 81 595-604 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Rybalkin, SD et al. (2003) PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. EMBO J. 22 469-78 PubMed GONUTS page
  5. ↑ Hu, W et al. (2010) The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model. Blood 116 1613-22 PubMed GONUTS page
  6. ↑ Serafini, P et al. (2006) Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J. Exp. Med. 203 2691-702 PubMed GONUTS page
  7. ↑ Heikaus, CC et al. (2008) Solution structure of the cGMP binding GAF domain from phosphodiesterase 5: insights into nucleotide specificity, dimerization, and cGMP-dependent conformational change. J. Biol. Chem. 283 22749-59 PubMed GONUTS page
  8. ↑ Isenberg, JS et al. (2005) Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 102 13141-6 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=MOUSE:PDE5A&oldid=5955976"