MOUSE:PDE4D

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pde4d
Protein Name(s)	cAMP-specific 3',5'-cyclic phosphodiesterase 4D DPDE3
External Links
UniProt	Q01063
EMBL	AF536978 AY388962 AK081466 CT025605 AC161585 AC163650 M94541
CCDS	CCDS49359.1
RefSeq	NP_035186.1 XP_006517710.1
UniGene	Mm.434429
ProteinModelPortal	Q01063
SMR	Q01063
BioGrid	232023
DIP	DIP-29706N
IntAct	Q01063
ChEMBL	CHEMBL2111373
PhosphoSite	Q01063
MaxQB	Q01063
PaxDb	Q01063
PRIDE	Q01063
Ensembl	ENSMUST00000074103 ENSMUST00000120664 ENSMUST00000122041 ENSMUST00000177907
GeneID	238871
KEGG	mmu:238871
UCSC	uc007rvg.2 uc007rvj.2
CTD	5144
MGI	MGI:99555
eggNOG	NOG122287
GeneTree	ENSGT00760000118889
HOGENOM	HOG000236297
HOVERGEN	HBG108239
InParanoid	Q01063
KO	K13293
OMA	DISAMCD
OrthoDB	EOG7HQNBC
PhylomeDB	Q01063
Reactome	REACT_203795 REACT_242871
UniPathway	UPA00762
NextBio	383911
PRO	PR:Q01063
Proteomes	UP000000589
Bgee	Q01063
CleanEx	MM_PDE4D
ExpressionAtlas	Q01063
Genevestigator	Q01063
GO	GO:0016324 GO:0034704 GO:0005737 GO:0005815 GO:0004114 GO:0051117 GO:0044325 GO:0046872 GO:0007568 GO:0006198 GO:0071872 GO:0071222 GO:0061028 GO:0050900 GO:0035264 GO:0045822 GO:0033137 GO:1901898 GO:0030593 GO:0086004 GO:1901844 GO:0002027 GO:0010880 GO:0060314 GO:0007165 GO:0006939
Gene3D	1.10.1300.10
InterPro	IPR003607 IPR023088 IPR002073 IPR023174
Pfam	PF00233
PRINTS	PR00387
SMART	SM00471
PROSITE	PS00126

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1901898	negative regulation of relaxation of cardiac muscle	PMID:21670503^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002131)	Seeded From UniProt	complete
involved_in	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction	PMID:16213210^[2]	ECO:0000305	curator inference used in manual assertion	GO:0002027 GO:0060314	P		Seeded From UniProt	complete
involved_in	GO:0086004	regulation of cardiac muscle cell contraction	PMID:21670503^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002131)	Seeded From UniProt	complete
involved_in	GO:0086004	regulation of cardiac muscle cell contraction	PMID:21903937^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071872	cellular response to epinephrine stimulus	PMID:16213210^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	PMID:16213210^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:E9Q401) occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	PMID:21903937^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O55143	F	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0045822	negative regulation of heart contraction	PMID:21903937^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:16213210^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:E9Q401	F	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:21670503^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01815	F	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	PMID:16213210^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0033137	negative regulation of peptidyl-serine phosphorylation	PMID:16213210^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000948) has_input:(UniProtKB:E9Q401)	Seeded From UniProt	complete
involved_in	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	PMID:16213210^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
part_of	GO:0005891	voltage-gated calcium channel complex	PMID:21670503^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000948)	Seeded From UniProt	complete
enables	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PMID:21670503^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0002027	regulation of heart rate	PMID:16213210^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061028	establishment of endothelial barrier	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14270	P		Seeded From UniProt	complete
involved_in	GO:0086004	regulation of cardiac muscle cell contraction	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99555 PANTHER:PTN000711155 RGD:3281	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99555 PANTHER:PTN000711155 UniProtKB:Q08499	F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99555 PANTHER:PTN000711155 UniProtKB:Q08499	F		Seeded From UniProt	complete
involved_in	GO:0043951	negative regulation of cAMP-mediated signaling	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000711155 UniProtKB:Q08499	P		Seeded From UniProt	complete
involved_in	GO:0006198	cAMP catabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000711155 UniProtKB:Q08499	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000711155 RGD:3281 UniProtKB:Q08499	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99555 PANTHER:PTN000711155 RGD:3281	C		Seeded From UniProt	complete
enables	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99555 MGI:MGI:99557 MGI:MGI:99558 PANTHER:PTN000886915 RGD:3280 UniProtKB:P27815 UniProtKB:Q07343 UniProtKB:Q08499	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:15585880^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2451168 MGI:MGI:3525068	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050900	leukocyte migration	PMID:15585880^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2451168 MGI:MGI:2451168	P	results_in_movement_of:(CL:0000775)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:10518565^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2451168	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030593	neutrophil chemotaxis	PMID:15585880^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2451168 MGI:MGI:2451168	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007568	aging	PMID:10518565^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2451168 MGI:MGI:2451182	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006939	smooth muscle contraction	PMID:14519662^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2451168	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:18983980^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	F		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	F		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	F		Seeded From UniProt	complete
involved_in	GO:0043951	negative regulation of cAMP-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	P		Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	C		Seeded From UniProt	complete
involved_in	GO:0032754	positive regulation of interleukin-5 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	P		Seeded From UniProt	complete
involved_in	GO:0032743	positive regulation of interleukin-2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	C		Seeded From UniProt	complete
enables	GO:0030552	cAMP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	F		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	C		Seeded From UniProt	complete
enables	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08499 ensembl:ENSP00000345502	F		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A140VJR0 ensembl:ENSP00000345502	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A140VJR0 ensembl:ENSP00000345502	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A140VJR0 ensembl:ENSP00000345502	C		Seeded From UniProt	complete
enables	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002073 InterPro:IPR036971	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002073 InterPro:IPR036971	P		Seeded From UniProt	complete
enables	GO:0008081	phosphoric diester hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023088 InterPro:IPR023174	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
involved_in	GO:0006198	cAMP catabolic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00762	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Leroy, J et al. (2011) Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice. J. Clin. Invest. 121 2651-61 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Lehnart, SE et al. (2005) Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell 123 25-35 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Beca, S et al. (2011) Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current. Circ. Res. 109 1024-30 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Ariga, M et al. (2004) Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation. J. Immunol. 173 7531-8 PubMed GONUTS page
↑ ^6.0 ^6.1 Jin, SL et al. (1999) Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 96 11998-2003 PubMed GONUTS page
↑ Méhats, C et al. (2003) PDE4D plays a critical role in the control of airway smooth muscle contraction. FASEB J. 17 1831-41 PubMed GONUTS page
↑ Bradshaw, NJ et al. (2008) DISC1, PDE4B, and NDE1 at the centrosome and synapse. Biochem. Biophys. Res. Commun. 377 1091-6 PubMed GONUTS page

[PMID:21670503-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Leroy, J et al. (2011) Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice. J. Clin. Invest. 121 2651-61 PubMed GONUTS page

[PMID:16213210-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Lehnart, SE et al. (2005) Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell 123 25-35 PubMed GONUTS page

[PMID:21903937-3] 3.0 ^3.1 ^3.2 Beca, S et al. (2011) Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current. Circ. Res. 109 1024-30 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15585880-5] 5.0 ^5.1 ^5.2 Ariga, M et al. (2004) Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation. J. Immunol. 173 7531-8 PubMed GONUTS page

[PMID:10518565-6] 6.0 ^6.1 Jin, SL et al. (1999) Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 96 11998-2003 PubMed GONUTS page

[PMID:14519662-7] Méhats, C et al. (2003) PDE4D plays a critical role in the control of airway smooth muscle contraction. FASEB J. 17 1831-41 PubMed GONUTS page

[PMID:18983980-8] Bradshaw, NJ et al. (2008) DISC1, PDE4B, and NDE1 at the centrosome and synapse. Biochem. Biophys. Res. Commun. 377 1091-6 PubMed GONUTS page

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MOUSE:PDE4D

Contents

Annotations

Notes

References

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