MOUSE:PAOX

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Paox (synonyms: Pao)
Protein Name(s)	Peroxisomal N(1)-acetyl-spermine/spermidine oxidase Polyamine oxidase
External Links
UniProt	Q8C0L6
EMBL	AF226656 AK030664 BC033913 BC082783
CCDS	CCDS21965.1
RefSeq	NP_722478.2
UniGene	Mm.486735
ProteinModelPortal	Q8C0L6
SMR	Q8C0L6
BindingDB	Q8C0L6
ChEMBL	CHEMBL3408
PhosphoSite	Q8C0L6
MaxQB	Q8C0L6
PaxDb	Q8C0L6
PRIDE	Q8C0L6
Ensembl	ENSMUST00000026537
GeneID	212503
KEGG	mmu:212503
UCSC	uc009kha.1 uc009khb.1
CTD	196743
MGI	MGI:1916983
eggNOG	COG1231
GeneTree	ENSGT00530000062888
HOGENOM	HOG000037651
HOVERGEN	HBG053499
InParanoid	Q8C0L6
KO	K00308
OMA	LESEYME
OrthoDB	EOG751NFD
PhylomeDB	Q8C0L6
TreeFam	TF318348
BioCyc	MetaCyc:MONOMER-14466
BRENDA	1.5.3.11
Reactome	REACT_243153 REACT_260206
UniPathway	UPA00826
NextBio	373584
PRO	PR:Q8C0L6
Proteomes	UP000000589
Bgee	Q8C0L6
CleanEx	MM_PAOX
ExpressionAtlas	Q8C0L6
Genevestigator	Q8C0L6
GO	GO:0005782 GO:0052899 GO:0052904 GO:0052903 GO:0046592 GO:0052902 GO:0052901 GO:0006598 GO:1901307 GO:0009446 GO:0009447 GO:0046203 GO:0046208
Gene3D	3.40.50.720
InterPro	IPR002937 IPR016040
Pfam	PF01593

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0046592	polyamine oxidase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1916983 MGI:MGI:2445356 PANTHER:PTN000077987 RGD:1306049 RGD:1561125 UniProtKB:Q6QHF9 UniProtKB:Q9NWM0	F	Seeded From UniProt	complete
involved_in	GO:0046208	spermine catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2445356 PANTHER:PTN002473328 RGD:1306049 RGD:1561125 UniProtKB:Q6QHF9 UniProtKB:Q9NWM0	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000743742 UniProtKB:O60341	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901307	positive regulation of spermidine biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6QHF9	P	Seeded From UniProt	complete
enables	GO:0046592	polyamine oxidase activity	PMID:12660232^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0046592	polyamine oxidase activity	PMID:12477380^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	EMBL:BC032778	F	Seeded From UniProt	complete
enables	GO:0046592	polyamine oxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6QHF9	F	Seeded From UniProt	complete
enables	GO:0046592	polyamine oxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1561125	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046208	spermine catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6QHF9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046208	spermine catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1561125	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046203	spermidine catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6QHF9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046203	spermidine catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1561125	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009447	putrescine catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6QHF9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009447	putrescine catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1561125	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009446	putrescine biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6QHF9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006598	polyamine catabolic process	PMID:12660232^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006598	polyamine catabolic process	PMID:12477380^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	EMBL:BC032778	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006598	polyamine catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6QHF9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006598	polyamine catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1561125	P	Seeded From UniProt	complete
part_of	GO:0005782	peroxisomal matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1561125	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6QHF9	F	Seeded From UniProt	complete
enables	GO:0046592	polyamine oxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3Z8W0 ensembl:ENSRNOP00000062187	F	Seeded From UniProt	complete
involved_in	GO:0046208	spermine catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3Z8W0 ensembl:ENSRNOP00000062187	P	Seeded From UniProt	complete
involved_in	GO:0046203	spermidine catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3Z8W0 ensembl:ENSRNOP00000062187	P	Seeded From UniProt	complete
involved_in	GO:0009447	putrescine catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3Z8W0 ensembl:ENSRNOP00000062187	P	Seeded From UniProt	complete
involved_in	GO:0006598	polyamine catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3Z8W0 ensembl:ENSRNOP00000062187	P	Seeded From UniProt	complete
part_of	GO:0005782	peroxisomal matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3Z8W0 ensembl:ENSRNOP00000062187	C	Seeded From UniProt	complete
involved_in	GO:1901307	positive regulation of spermidine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6QHF9 ensembl:ENSP00000278060	P	Seeded From UniProt	complete
enables	GO:0046592	polyamine oxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6QHF9 ensembl:ENSP00000278060	F	Seeded From UniProt	complete
involved_in	GO:0046208	spermine catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6QHF9 ensembl:ENSP00000278060	P	Seeded From UniProt	complete
involved_in	GO:0046203	spermidine catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6QHF9 ensembl:ENSP00000278060	P	Seeded From UniProt	complete
involved_in	GO:0009447	putrescine catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6QHF9 ensembl:ENSP00000278060	P	Seeded From UniProt	complete
involved_in	GO:0009446	putrescine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6QHF9 ensembl:ENSP00000278060	P	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6QHF9 ensembl:ENSP00000278060	F	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002937	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002937	P	Seeded From UniProt	complete
enables	GO:0052902	spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.3.13	F	Seeded From UniProt	complete
enables	GO:0052899	N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.3.13	F	Seeded From UniProt	complete
enables	GO:0052901	spermine:oxygen oxidoreductase (spermidine-forming) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.3.13	F	Seeded From UniProt	complete
enables	GO:0052904	N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.3.13	F	Seeded From UniProt	complete
enables	GO:0052903	N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.3.13	F	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0576 UniProtKB-SubCell:SL-0204	C	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
involved_in	GO:0008215	spermine metabolic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00826	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 Wu, T et al. (2003) Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase. J. Biol. Chem. 278 20514-25 PubMed GONUTS page
↑ ^3.0 ^3.1 Vujcic, S et al. (2003) Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. Biochem. J. 370 19-28 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12660232-2] 2.0 ^2.1 Wu, T et al. (2003) Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase. J. Biol. Chem. 278 20514-25 PubMed GONUTS page

[PMID:12477380-3] 3.0 ^3.1 Vujcic, S et al. (2003) Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. Biochem. J. 370 19-28 PubMed GONUTS page

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MOUSE:PAOX

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Annotations

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