MOUSE:OPN4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Opn4 (synonyms: Mop, Mopn)
Protein Name(s)	Melanopsin Opsin-4
External Links
UniProt	Q9QXZ9
EMBL	AF147789 EU303117 EU303118 AC114543 BC139827
CCDS	CCDS26943.1 CCDS49446.1
RefSeq	NP_001122071.1 NP_038915.1
UniGene	Mm.272060
ProteinModelPortal	Q9QXZ9
SMR	Q9QXZ9
IntAct	Q9QXZ9
STRING	10090.ENSMUSP00000022331
PRIDE	Q9QXZ9
Ensembl	ENSMUST00000022331 ENSMUST00000168444
GeneID	30044
KEGG	mmu:30044
UCSC	uc007tbh.2 uc011ziw.1
CTD	94233
MGI	MGI:1353425
eggNOG	NOG255465
GeneTree	ENSGT00760000118977
HOGENOM	HOG000264261
HOVERGEN	HBG007871
InParanoid	Q9QXZ9
KO	K04255
OMA	RMAIAQH
OrthoDB	EOG7CNZG2
PhylomeDB	Q9QXZ9
TreeFam	TF324998
Reactome	REACT_207651 REACT_245980
NextBio	307136
PRO	PR:Q9QXZ9
Proteomes	UP000000589
Bgee	Q9QXZ9
CleanEx	MM_OPN4
Genevestigator	Q9QXZ9
GO	GO:0016021 GO:0005886 GO:0005502 GO:0008020 GO:0007602 GO:0018298 GO:0042752 GO:0016056 GO:0048511 GO:0007601
InterPro	IPR000276 IPR017452 IPR001760 IPR027430
Pfam	PF00001
PRINTS	PR00237 PR00238
PROSITE	PS00237 PS50262 PS00238

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001503	ossification	PMID:E7D7Z2	ECO:0000270			P		figure 1	complete CACAO 5058
involved_in	GO:0042752	regulation of circadian rhythm	PMID:12808468^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008020	G protein-coupled photoreceptor activity	PMID:12808468^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007602	phototransduction	PMID:12808468^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005502	11-cis retinal binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UHM6	F		Seeded From UniProt	complete
involved_in	GO:0071482	cellular response to light stimulus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002940 MGI:MGI:97914 PANTHER:PTN000662115 UniProtKB:D0E2W5 UniProtKB:F1NEY8	P		Seeded From UniProt	complete
enables	GO:0008020	G protein-coupled photoreceptor activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002940 FB:FBgn0003249 FB:FBgn0003250 FB:FBgn0014019 FB:FBgn0019940 MGI:MGI:1353425 PANTHER:PTN000662115 RGD:621701 UniProtKB:D0E2W5 UniProtKB:F1NEY2 UniProtKB:F1NEY8 UniProtKB:P02699 UniProtKB:Q9UHM6	F		Seeded From UniProt	complete
involved_in	GO:0007602	phototransduction	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002940 FB:FBgn0014019 FB:FBgn0019940 MGI:MGI:1353425 MGI:MGI:97914 PANTHER:PTN000662115 RGD:621701 UniProtKB:F1RAF0 UniProtKB:Q9UHM6 ZFIN:ZDB-GENE-040724-51 ZFIN:ZDB-GENE-061201-30 ZFIN:ZDB-GENE-081105-91	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000662115 UniProtKB:P08100 ZFIN:ZDB-GENE-070111-2 ZFIN:ZDB-GENE-080415-3 ZFIN:ZDB-GENE-110622-1	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1929473 PANTHER:PTN000662115 UniProtKB:P02699	C		Seeded From UniProt	complete
enables	GO:0008020	G protein-coupled photoreceptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHM6	F		Seeded From UniProt	complete
enables	GO:0008020	G protein-coupled photoreceptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621701	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007602	phototransduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHM6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007602	phototransduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621701	P		Seeded From UniProt	complete
enables	GO:0005502	11-cis retinal binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHM6	F		Seeded From UniProt	complete
involved_in	GO:0009584	detection of visible light	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008020	P		Seeded From UniProt	complete
involved_in	GO:0009584	detection of visible light	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008020	P		Seeded From UniProt	complete
involved_in	GO:0009584	detection of visible light	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008020	P		Seeded From UniProt	complete
involved_in	GO:0009584	detection of visible light	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008020	P		Seeded From UniProt	complete
involved_in	GO:0009584	detection of visible light	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008020	P		Seeded From UniProt	complete
involved_in	GO:0009584	detection of visible light	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008020	P		Seeded From UniProt	complete
enables	GO:0008020	G protein-coupled photoreceptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R456 ensembl:ENSRNOP00000069548	F		Seeded From UniProt	complete
involved_in	GO:0007602	phototransduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R456 ensembl:ENSRNOP00000069548	P		Seeded From UniProt	complete
enables	GO:0008020	G protein-coupled photoreceptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UHM6 ensembl:ENSP00000361141	F		Seeded From UniProt	complete
involved_in	GO:0007602	phototransduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UHM6 ensembl:ENSP00000361141	P		Seeded From UniProt	complete
enables	GO:0005502	11-cis retinal binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UHM6 ensembl:ENSP00000361141	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR001760	P		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001760	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR001760 InterPro:IPR017452	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045938	positive regulation of circadian sleep/wake cycle, sleep	PMID:26320947^[3]	ECO:0006050	anti-sense experiment evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043153	entrainment of circadian clock by photoperiod	PMID:26320947^[3]	ECO:0006050	anti-sense experiment evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016056	rhodopsin mediated signaling pathway	PMID:19793992^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000740)	Seeded From UniProt	complete
enables	GO:0008020	G protein-coupled photoreceptor activity	PMID:19793992^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000740)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19793992^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045938	positive regulation of circadian sleep/wake cycle, sleep	PMID:26320947^[3]	ECO:0006050	anti-sense experiment evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043153	entrainment of circadian clock by photoperiod	PMID:26320947^[3]	ECO:0006050	anti-sense experiment evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016056	rhodopsin mediated signaling pathway	PMID:19793992^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000740)	Seeded From UniProt	complete
enables	GO:0008020	G protein-coupled photoreceptor activity	PMID:19793992^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000740)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19793992^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000740)	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:10632589^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0018298	protein-chromophore linkage	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0157	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0007602	phototransduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0681	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P		Seeded From UniProt	complete
enables	GO:0009881	photoreceptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0600	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Hattar, S et al. (2003) Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature 424 76-81 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Jagannath, A et al. (2015) Isoforms of Melanopsin Mediate Different Behavioral Responses to Light. Curr. Biol. 25 2430-4 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Pires, SS et al. (2009) Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina. J. Neurosci. 29 12332-42 PubMed GONUTS page
↑ Provencio, I et al. (2000) A novel human opsin in the inner retina. J. Neurosci. 20 600-5 PubMed GONUTS page

[PMID:12808468-1] 1.0 ^1.1 ^1.2 Hattar, S et al. (2003) Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature 424 76-81 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26320947-3] 3.0 ^3.1 ^3.2 ^3.3 Jagannath, A et al. (2015) Isoforms of Melanopsin Mediate Different Behavioral Responses to Light. Curr. Biol. 25 2430-4 PubMed GONUTS page

[PMID:19793992-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Pires, SS et al. (2009) Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina. J. Neurosci. 29 12332-42 PubMed GONUTS page

[PMID:10632589-5] Provencio, I et al. (2000) A novel human opsin in the inner retina. J. Neurosci. 20 600-5 PubMed GONUTS page

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MOUSE:OPN4

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