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MOUSE:ONCM
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Osm | |
| Protein Name(s) | Oncostatin-M
OSM | |
| External Links | ||
| UniProt | P53347 | |
| EMBL | D31942 AK155637 AL807825 BC099866 | |
| CCDS | CCDS24382.1 | |
| PIR | S64719 | |
| RefSeq | NP_001013383.1 | |
| UniGene | Mm.131422 | |
| ProteinModelPortal | P53347 | |
| SMR | P53347 | |
| DIP | DIP-5786N | |
| PhosphoSite | P53347 | |
| PRIDE | P53347 | |
| Ensembl | ENSMUST00000075221 | |
| GeneID | 18413 | |
| KEGG | mmu:18413 | |
| UCSC | uc007hus.2 | |
| CTD | 5008 | |
| MGI | MGI:104749 | |
| eggNOG | NOG39662 | |
| GeneTree | ENSGT00390000004850 | |
| HOGENOM | HOG000074128 | |
| HOVERGEN | HBG007867 | |
| InParanoid | P53347 | |
| KO | K05418 | |
| OMA | GYHRFMH | |
| OrthoDB | EOG7NGQC9 | |
| PhylomeDB | P53347 | |
| TreeFam | TF338204 | |
| NextBio | 294040 | |
| PRO | PR:P53347 | |
| Proteomes | UP000000589 | |
| Bgee | P53347 | |
| CleanEx | MM_OSM | |
| Genevestigator | P53347 | |
| GO | GO:0005615 GO:0005900 GO:0005125 GO:0048266 GO:0006955 GO:0046888 GO:0045835 GO:0007422 GO:2001235 GO:0008284 GO:0043410 GO:0033138 GO:0050731 GO:0045944 GO:0040008 GO:0009408 GO:0042508 GO:0042503 GO:0042506 | |
| Gene3D | 1.20.1250.10 | |
| InterPro | IPR009079 IPR012351 IPR001581 IPR019827 | |
| Pfam | PF01291 | |
| SMART | SM00080 | |
| SUPFAM | SSF47266 | |
| PROSITE | PS00590 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0032735 |
cytokine activity |
ECO:0000314 |
F |
Figure 2. Cytokine (IL-12p70) production by OSM-treated DCs. |
complete | |||||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104749 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2001235 |
positive regulation of apoptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1905078 |
positive regulation of interleukin-17 secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051897 |
positive regulation of protein kinase B signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048266 |
behavioral response to pain |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3574987 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046888 |
negative regulation of hormone secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045835 |
negative regulation of meiotic nuclear division |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0000021) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043410 |
positive regulation of MAPK cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0038165 |
oncostatin-M-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0009408 |
response to heat |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3574987 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007422 |
peripheral nervous system development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3574987 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007260 |
tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005147 |
oncostatin-M receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005147 |
oncostatin-M receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0038165 |
oncostatin-M-mediated signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0040008 |
regulation of growth |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Jung, ID et al. (2010) Oncostatin M induces dendritic cell maturation and Th1 polarization. Biochem. Biophys. Res. Commun. 394 272-8 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Auernhammer, CJ et al. (2004) The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells. J. Endocrinol. 180 479-86 PubMed GONUTS page
- ↑ Qin, S et al. (2013) Cross-talk between KLF4 and STAT3 regulates axon regeneration. Nat Commun 4 2633 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Morikawa, Y et al. (2004) Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia. J. Neurosci. 24 1941-7 PubMed GONUTS page
- ↑ Chuma, S & Nakatsuji, N (2001) Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling. Dev. Biol. 229 468-79 PubMed GONUTS page
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- GO:0007422 ! peripheral nervous system development
- GO:0032735 ! positive regulation of interleukin-12 production
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
- GO:0008284 ! positive regulation of cell population proliferation
- GO:2001235 ! positive regulation of apoptotic signaling pathway
- GO:1905078 ! positive regulation of interleukin-17 secretion
- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
- GO:0043410 ! positive regulation of MAPK cascade
- GO:0051897 ! positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0050729 ! positive regulation of inflammatory response
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