MOUSE:NRG4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nrg4
Protein Name(s)	Pro-neuregulin-4, membrane-bound isoform Pro-NRG4 Neuregulin-4 NRG-4
External Links
UniProt	Q9WTX4
EMBL	AF083067
CCDS	CCDS52801.1
RefSeq	NP_114391.1 XP_006511631.1 XP_006511632.1 XP_006511633.1
UniGene	Mm.443874
ProteinModelPortal	Q9WTX4
SMR	Q9WTX4
STRING	10090.ENSMUSP00000079037
PRIDE	Q9WTX4
Ensembl	ENSMUST00000130158 ENSMUST00000164721
GeneID	83961
KEGG	mmu:83961
UCSC	uc009psf.2
CTD	145957
MGI	MGI:1933833
eggNOG	NOG42904
GeneTree	ENSGT00390000014815
HOGENOM	HOG000113853
HOVERGEN	HBG006533
InParanoid	Q9WTX4
KO	K05458
OMA	CRCIENY
PhylomeDB	Q9WTX4
Reactome	REACT_188191 REACT_188528 REACT_188574 REACT_188579 REACT_188580 REACT_196588 REACT_198574 REACT_203296 REACT_215348 REACT_226341
NextBio	350830
PRO	PR:Q9WTX4
Proteomes	UP000000589
Bgee	Q9WTX4
CleanEx	MM_NRG4
ExpressionAtlas	Q9WTX4
Genevestigator	Q9WTX4
GO	GO:0005576 GO:0016021 GO:0005886
InterPro	IPR000742 IPR013032
SMART	SM00181
PROSITE	PS00022 PS50026

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008083	growth factor activity	PMID:10348342	ECO:0000316		UniProtKB:Q9WTX4	F		Figure (1c): Alignment of the amino acid sequence of the EGF-like domain of NRG-4 with the EGF-like motifs of other growth factors. Figure(1a): NRG-4 binding to ErbB proteins. Covalent crosslinking of NRG-4 to recombinant-soluble ErbB proteins. The four soluble forms of ErbB proteins, in the form of IgG fusions (denoted IgB-1 through -4), were separately incubated with the indicated radiolabeled growth factors.	complete CACAO 10500
involved_in	GO:0035556	intracellular signal transduction		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1097165 PANTHER:PTN000873337	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000873337 RGD:621341 UniProtKB:Q02297	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000873337 UniProtKB:Q02297	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040180	F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040180	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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References

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