MOUSE:NRARP

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nrarp
Protein Name(s)	Notch-regulated ankyrin repeat-containing protein
External Links
UniProt	Q91ZA8
EMBL	AY046077 AK012426 AL732309 BC048088 BC069891
CCDS	CCDS38066.1
RefSeq	NP_080256.2
UniGene	Mm.46539
ProteinModelPortal	Q91ZA8
SMR	Q91ZA8
STRING	10090.ENSMUSP00000100615
PRIDE	Q91ZA8
Ensembl	ENSMUST00000104999
GeneID	67122
KEGG	mmu:67122
UCSC	uc008iqk.1
CTD	441478
MGI	MGI:1914372
eggNOG	NOG258278
GeneTree	ENSGT00730000110992
HOGENOM	HOG000082661
HOVERGEN	HBG097373
InParanoid	Q91ZA8
OMA	KYAGSGR
OrthoDB	EOG7M98JC
PhylomeDB	Q91ZA8
NextBio	323639
PRO	PR:Q91ZA8
Proteomes	UP000000589
Bgee	Q91ZA8
CleanEx	MM_NRARP
Genevestigator	Q91ZA8
GO	GO:0002043 GO:0045746 GO:1902367 GO:0045581 GO:0000122 GO:0001569 GO:0090263 GO:0001938 GO:0022407 GO:0032525 GO:0002040
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683
Pfam	PF12796
SMART	SM00248
SUPFAM	SSF48403
PROSITE	PS50297 PS50088

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7Z6K4	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000653900 UniProtKB:Q7Z6K4	P		Seeded From UniProt	complete
involved_in	GO:0045746	negative regulation of Notch signaling pathway	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914372 PANTHER:PTN000653900 UniProtKB:Q7Z6K4	P		Seeded From UniProt	complete
involved_in	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914372 PANTHER:PTN000653900	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914372 PANTHER:PTN000653900	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914372 PANTHER:PTN000653900	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902367	negative regulation of Notch signaling pathway involved in somitogenesis	PMID:21795391^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5317888	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q7Z6K4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045746	negative regulation of Notch signaling pathway	PMID:12794108^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97363	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045746	negative regulation of Notch signaling pathway	PMID:21998026^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16752)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045746	negative regulation of Notch signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q7Z6K4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045581	negative regulation of T cell differentiation	PMID:12794108^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:32760) regulates_o_results_in_acquisition_of_features_of:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032525	somite rostral/caudal axis specification	PMID:21998026^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5438570	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022407	regulation of cell-cell adhesion	PMID:19154719^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3833551	P	regulates_o_has_participant:(EMAPA:36520) regulates_o_has_participant:(CL:0000071)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022407	regulation of cell-cell adhesion	PMID:19154719^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7T3X9 UniProtKB:Q7T3Y0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q7Z6K4	P		Seeded From UniProt	complete
part_of	GO:0005575	cellular_component	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	PMID:19154719^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3833551	P	occurs_in:(EMAPA:36520) acts_on_population_of:(CL:0000071)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002040	sprouting angiogenesis	PMID:19154719^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3833551	P	has_participant:(EMAPA:36520)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002040	sprouting angiogenesis	GO_REF:0000008	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7T3X9 UniProtKB:Q7T3Y0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	PMID:19154719^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3833551	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001569	branching involved in blood vessel morphogenesis	PMID:19154719^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3833551	P	occurs_in:(EMAPA:36520)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000008	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7T3X9 UniProtKB:Q7T3Y0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12794108^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96522 MGI:MGI:97363	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7Z6K4 ensembl:ENSP00000349041	P		Seeded From UniProt	complete
involved_in	GO:0045746	negative regulation of Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7Z6K4 ensembl:ENSP00000349041	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7Z6K4 ensembl:ENSP00000349041	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Kim, W et al. (2011) The period of the somite segmentation clock is sensitive to Notch activity. Mol. Biol. Cell 22 3541-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Yun, TJ & Bevan, MJ (2003) Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development. J. Immunol. 170 5834-41 PubMed GONUTS page
↑ ^4.0 ^4.1 Krebs, LT et al. (2012) The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice. Genesis 50 366-74 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Phng, LK et al. (2009) Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev. Cell 16 70-82 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21795391-2] Kim, W et al. (2011) The period of the somite segmentation clock is sensitive to Notch activity. Mol. Biol. Cell 22 3541-9 PubMed GONUTS page

[PMID:12794108-3] 3.0 ^3.1 ^3.2 Yun, TJ & Bevan, MJ (2003) Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development. J. Immunol. 170 5834-41 PubMed GONUTS page

[PMID:21998026-4] 4.0 ^4.1 Krebs, LT et al. (2012) The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice. Genesis 50 366-74 PubMed GONUTS page

[PMID:19154719-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Phng, LK et al. (2009) Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev. Cell 16 70-82 PubMed GONUTS page

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MOUSE:NRARP

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