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MOUSE:NPC2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Npc2 | |
| Protein Name(s) | Epididymal secretory protein E1
mE1 Niemann Pick type C2 protein homolog | |
| External Links | ||
| UniProt | Q9Z0J0 | |
| EMBL | AB021289 AK008603 AK009127 AK151067 AK151133 AK153020 AK153203 AK158624 AK165263 AK167869 AK170327 BC003471 BC007190 | |
| CCDS | CCDS26050.1 | |
| RefSeq | NP_075898.1 | |
| UniGene | Mm.282556 | |
| ProteinModelPortal | Q9Z0J0 | |
| SMR | Q9Z0J0 | |
| IntAct | Q9Z0J0 | |
| MINT | MINT-4104065 | |
| STRING | 10090.ENSMUSP00000021668 | |
| PhosphoSite | Q9Z0J0 | |
| MaxQB | Q9Z0J0 | |
| PaxDb | Q9Z0J0 | |
| PRIDE | Q9Z0J0 | |
| Ensembl | ENSMUST00000021668 | |
| GeneID | 67963 | |
| KEGG | mmu:67963 | |
| UCSC | uc007oft.1 | |
| CTD | 10577 | |
| MGI | MGI:1915213 | |
| eggNOG | NOG281614 | |
| GeneTree | ENSGT00390000006223 | |
| HOGENOM | HOG000007181 | |
| HOVERGEN | HBG018181 | |
| InParanoid | Q9Z0J0 | |
| KO | K13443 | |
| OMA | CKSGISC | |
| OrthoDB | EOG7SBNQN | |
| PhylomeDB | Q9Z0J0 | |
| TreeFam | TF317963 | |
| ChiTaRS | Npc2 | |
| NextBio | 326080 | |
| PRO | PR:Q9Z0J0 | |
| Proteomes | UP000000589 | |
| Bgee | Q9Z0J0 | |
| CleanEx | MM_NPC2 | |
| Genevestigator | Q9Z0J0 | |
| GO | GO:0005783 GO:0070062 GO:0005764 GO:0015485 GO:0033344 GO:0042632 GO:0008203 GO:0030301 GO:0032367 GO:0032366 GO:0009615 | |
| Gene3D | 2.60.40.770 | |
| InterPro | IPR014756 IPR003172 | |
| Pfam | PF02221 | |
| SMART | SM00737 | |
| SUPFAM | SSF81296 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
ECO:0000021 |
|
F |
figure 1A |
complete | ||||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
produced_by:(CL:0002548) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042632 |
cholesterol homeostasis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032367 |
intracellular cholesterol transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032366 |
intracellular sterol transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030301 |
cholesterol transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015485 |
cholesterol binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033344 |
cholesterol efflux |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030301 |
cholesterol transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015485 |
cholesterol binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042632 |
cholesterol homeostasis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0033344 |
cholesterol efflux |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032367 |
intracellular cholesterol transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032366 |
intracellular sterol transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030301 |
cholesterol transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017127 |
cholesterol transporter activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015485 |
cholesterol binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032367 |
intracellular cholesterol transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008202 |
steroid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008203 |
cholesterol metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006869 |
lipid transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Harrison, KD et al. (2009) Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metab. 10 208-18 PubMed GONUTS page
- ↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
- ↑ Frolov, A et al. (2003) NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. J. Biol. Chem. 278 25517-25 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Liou, HL et al. (2006) NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols. J. Biol. Chem. 281 36710-23 PubMed GONUTS page
- ↑ Naureckiene, S et al. (2000) Identification of HE1 as the second gene of Niemann-Pick C disease. Science 290 2298-301 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Yamanashi, Y et al. (2011) NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport. Gastroenterology 140 1664-74 PubMed GONUTS page
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