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MOUSE:NKD1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Nkd1
Protein Name(s) Protein naked cuticle homolog 1

Naked-1 mNkd mNkd1

External Links
UniProt Q99MH6
EMBL AF358134
AF343352
BC034838
AK166564
CCDS CCDS22511.1
RefSeq NP_081556.3
UniGene Mm.30219
ProteinModelPortal Q99MH6
IntAct Q99MH6
PhosphoSite Q99MH6
PRIDE Q99MH6
Ensembl ENSMUST00000034086
GeneID 93960
KEGG mmu:93960
UCSC uc009mro.2
CTD 85407
MGI MGI:2135954
eggNOG NOG47986
GeneTree ENSGT00440000033589
HOGENOM HOG000005649
HOVERGEN HBG099718
InParanoid Q99MH6
KO K03213
OMA LGHKKHK
OrthoDB EOG75F4D6
PhylomeDB Q99MH6
TreeFam TF328786
ChiTaRS Nkd1
NextBio 351953
PRO PR:Q99MH6
Proteomes UP000000589
Bgee Q99MH6
CleanEx MM_NKD1
ExpressionAtlas Q99MH6
Genevestigator Q99MH6
GO GO:0005737
GO:0005886
GO:0000159
GO:0005509
GO:0030165
GO:0030154
GO:0007275
GO:0090090
GO:1901233
GO:0030178
GO:1901231
GO:0045732
GO:2000096
GO:0007283
GO:0016055
Gene3D 1.10.238.10
InterPro IPR011992
IPR018247
IPR002048
PROSITE PS00018
PS50222

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:2000096

positive regulation of Wnt signaling pathway, planar cell polarity pathway

PMID:11274398[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901233

negative regulation of convergent extension involved in axis elongation

PMID:11274398[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901231

positive regulation of non-canonical Wnt signaling pathway via JNK cascade

PMID:11274398[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:11356022[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:11274398[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030178

negative regulation of Wnt signaling pathway

PMID:11356022[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9VVV9

P

Seeded From UniProt

complete

enables

GO:0030165

PDZ domain binding

PMID:11356022[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P51140

F

Seeded From UniProt

complete

involved_in

GO:0030178

negative regulation of Wnt signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2135954
PANTHER:PTN001098752

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002945
PANTHER:PTN001098752
ZFIN:ZDB-GENE-061108-3

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090090

negative regulation of canonical Wnt signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q969G9

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045732

positive regulation of protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q969G9

P

Seeded From UniProt

complete

part_of

GO:0000159

protein phosphatase type 2A complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q969G9

C

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q969G9
ensembl:ENSP00000268459

P

Seeded From UniProt

complete

involved_in

GO:0045732

positive regulation of protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q969G9
ensembl:ENSP00000268459

P

Seeded From UniProt

complete

part_of

GO:0000159

protein phosphatase type 2A complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q969G9
ensembl:ENSP00000268459

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002048

F

Seeded From UniProt

complete

involved_in

GO:0030178

negative regulation of Wnt signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040140

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0744

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Yan, D et al. (2001) Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc. Natl. Acad. Sci. U.S.A. 98 3802-7 PubMed GONUTS page
  2. 2.0 2.1 2.2 Wharton, KA Jr et al. (2001) Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev. Biol. 234 93-106 PubMed GONUTS page
  3. 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page