MOUSE:MYPT1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ppp1r12a (synonyms: Mypt1)
Protein Name(s)	Protein phosphatase 1 regulatory subunit 12A Myosin phosphatase-targeting subunit 1 Myosin phosphatase target subunit 1
External Links
UniProt	Q9DBR7
EMBL	AK035230 AK004785 CH466539 BC125381 BC137630 AB042280
CCDS	CCDS36052.1
RefSeq	NP_082168.1 XP_006513389.1
UniGene	Mm.422959 Mm.489819
ProteinModelPortal	Q9DBR7
SMR	Q9DBR7
DIP	DIP-29982N
IntAct	Q9DBR7
MINT	MINT-4102998
STRING	10090.ENSMUSP00000100915
PhosphoSite	Q9DBR7
MaxQB	Q9DBR7
PaxDb	Q9DBR7
PRIDE	Q9DBR7
Ensembl	ENSMUST00000070663
GeneID	17931
KEGG	mmu:17931
UCSC	uc007gzc.1 uc007gzd.1
CTD	4659
MGI	MGI:1309528
eggNOG	COG0666
GeneTree	ENSGT00760000119141
HOGENOM	HOG000290648
HOVERGEN	HBG052561
InParanoid	Q9DBR7
KO	K06270
OMA	TDKQTTT
OrthoDB	EOG7060Q5
PhylomeDB	Q9DBR7
TreeFam	TF105543
Reactome	REACT_196635
ChiTaRS	Ppp1r12a
NextBio	292815
PMAP-CutDB	Q9DBR7
PRO	PR:Q9DBR7
Proteomes	UP000000589
Bgee	Q9DBR7
Genevestigator	Q9DBR7
GO	GO:0015629 GO:0005813 GO:0043292 GO:0000776 GO:0072357 GO:0071889 GO:0004857 GO:0019208 GO:0051297 GO:0007067 GO:0043086 GO:0045944 GO:0006470 GO:0030155 GO:0035507 GO:0046822
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR017401
Pfam	PF12796
PIRSF	PIRSF038141
PRINTS	PR01415
SMART	SM00248
SUPFAM	SSF48403
PROSITE	PS50297 PS50088

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0031672	A band	PMID:11067852^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:11067852^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0072357	PTW/PP1 phosphatase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14974	C		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14974	F		Seeded From UniProt	complete
involved_in	GO:0007098	centrosome cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
involved_in	GO:0043086	negative regulation of catalytic activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
involved_in	GO:0035507	regulation of myosin-light-chain-phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
enables	GO:0019208	phosphatase regulator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14974	F		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14974	C		Seeded From UniProt	complete
enables	GO:0004857	enzyme inhibitor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14974	F		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14974	C		Seeded From UniProt	complete
involved_in	GO:0035508	positive regulation of myosin-light-chain-phosphatase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652892 UniProtKB:O14974	P		Seeded From UniProt	complete
part_of	GO:0031672	A band	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1309528 MGI:MGI:1916417 PANTHER:PTN000652891	C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1309528 MGI:MGI:1916417 PANTHER:PTN000652891	C		Seeded From UniProt	complete
enables	GO:0019208	phosphatase regulator activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001193544 UniProtKB:O14974	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001193544 WB:WBGene00003196	C		Seeded From UniProt	complete
enables	GO:0004857	enzyme inhibitor activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001193544 UniProtKB:O14974	F		Seeded From UniProt	complete
part_of	GO:0072357	PTW/PP1 phosphatase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	C		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046822	regulation of nucleocytoplasmic transport	PMID:17369396^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
part_of	GO:0043292	contractile fiber	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043086	negative regulation of catalytic activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035690	cellular response to drug	PMID:18524939^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035508	positive regulation of myosin-light-chain-phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035507	regulation of myosin-light-chain-phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030155	regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	F		Seeded From UniProt	complete
enables	GO:0019208	phosphatase regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	F		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007098	centrosome cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006470	protein dephosphorylation	PMID:17369396^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(MGI:MGI:1891835)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006470	protein dephosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	C		Seeded From UniProt	complete
enables	GO:0004857	enzyme inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	F		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000278	mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14974	P		Seeded From UniProt	complete
part_of	GO:0072357	PTW/PP1 phosphatase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	C		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	P		Seeded From UniProt	complete
part_of	GO:0043292	contractile fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	C		Seeded From UniProt	complete
involved_in	GO:0043086	negative regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	P		Seeded From UniProt	complete
involved_in	GO:0035508	positive regulation of myosin-light-chain-phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	P		Seeded From UniProt	complete
involved_in	GO:0035507	regulation of myosin-light-chain-phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	F		Seeded From UniProt	complete
enables	GO:0019208	phosphatase regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	F		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	C		Seeded From UniProt	complete
involved_in	GO:0007098	centrosome cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	C		Seeded From UniProt	complete
enables	GO:0004857	enzyme inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	F		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	C		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14974 ensembl:ENSP00000389168	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017401	P		Seeded From UniProt	complete
enables	GO:0019208	phosphatase regulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017401	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031775	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Arimura, T et al. (2001) Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit. J. Biol. Chem. 276 6073-82 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Parra, M et al. (2007) Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes. Genes Dev. 21 638-43 PubMed GONUTS page
↑ Mizuno, Y et al. (2008) Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo. Am. J. Physiol., Cell Physiol. 295 C358-64 PubMed GONUTS page

[PMID:11067852-1] 1.0 ^1.1 Arimura, T et al. (2001) Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit. J. Biol. Chem. 276 6073-82 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17369396-3] 3.0 ^3.1 Parra, M et al. (2007) Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes. Genes Dev. 21 638-43 PubMed GONUTS page

[PMID:18524939-4] Mizuno, Y et al. (2008) Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo. Am. J. Physiol., Cell Physiol. 295 C358-64 PubMed GONUTS page

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MOUSE:MYPT1

Contents

Annotations

Notes

References

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