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MOUSE:MTR1A

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Mtnr1a
Protein Name(s) Melatonin receptor type 1A

Mel-1A-R Mel1a receptor

External Links
UniProt Q61184
EMBL U52222
CCDS CCDS22273.1
RefSeq NP_032665.1
UniGene Mm.5133
ProteinModelPortal Q61184
SMR Q61184
GuidetoPHARMACOLOGY 287
PRIDE Q61184
Ensembl ENSMUST00000067984
GeneID 17773
KEGG mmu:17773
UCSC uc009loq.1
CTD 4543
MGI MGI:102967
eggNOG NOG138016
GeneTree ENSGT00440000033318
HOGENOM HOG000037953
HOVERGEN HBG052528
InParanoid Q61184
KO K04285
OMA LMTNNNV
OrthoDB EOG7MD4Q5
PhylomeDB Q61184
TreeFam TF331693
Reactome REACT_250376
REACT_261161
NextBio 292495
PRO PR:Q61184
Proteomes UP000000589
Bgee Q61184
CleanEx MM_MTNR1A
ExpressionAtlas Q61184
Genevestigator Q61184
GO GO:0005887
GO:0043235
GO:0042562
GO:0008502
GO:0097159
GO:0007623
GO:0030828
InterPro IPR000276
IPR017452
IPR002278
IPR000025
Pfam PF00001
PRINTS PR00237
PR01149
PR00857
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0007623

circadian rhythm

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000663028
RGD:620797

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0025631
MGI:MGI:87964
PANTHER:PTN001200934
RGD:2070
RGD:2072
RGD:2201
RGD:620401
RGD:621645
UniProtKB:P30411
UniProtKB:P30556
UniProtKB:P35414
UniProtKB:P48039
UniProtKB:P49685
UniProtKB:Q13585
ZFIN:ZDB-GENE-141216-12

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1918473
MGI:MGI:2441843
MGI:MGI:87964
MGI:MGI:87966
PANTHER:PTN001200934
RGD:2070
RGD:2201
RGD:620401
UniProtKB:P30411
UniProtKB:P30556
UniProtKB:P48039
UniProtKB:P49685
UniProtKB:P50052
ZFIN:ZDB-GENE-030814-1
ZFIN:ZDB-GENE-050913-90
ZFIN:ZDB-GENE-141216-12

F

Seeded From UniProt

complete

enables

GO:0097159

organic cyclic compound binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48039

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046676

negative regulation of insulin secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620797

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48039

C

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620797

C

Seeded From UniProt

complete

enables

GO:0042562

hormone binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48039

F

Seeded From UniProt

complete

enables

GO:0008502

melatonin receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48039

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007193

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48039

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48039

C

Seeded From UniProt

complete

enables

GO:0097159

organic cyclic compound binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48039
ensembl:ENSP00000302811

F

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48039
ensembl:ENSP00000302811

C

Seeded From UniProt

complete

enables

GO:0042562

hormone binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48039
ensembl:ENSP00000302811

F

Seeded From UniProt

complete

enables

GO:0008502

melatonin receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48039
ensembl:ENSP00000302811

F

Seeded From UniProt

complete

involved_in

GO:0007193

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48039
ensembl:ENSP00000302811

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48039
ensembl:ENSP00000302811

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000025
InterPro:IPR000276
InterPro:IPR002278
InterPro:IPR027459

P

Seeded From UniProt

complete

enables

GO:0008502

melatonin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000025
InterPro:IPR002278
InterPro:IPR027459

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000025
InterPro:IPR000276
InterPro:IPR002278
InterPro:IPR017452
InterPro:IPR027459

C

Seeded From UniProt

complete

enables

GO:0008502

melatonin receptor activity

PMID:8923472[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007623

circadian rhythm

PMID:8923472[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 Weaver, DR et al. (1996) Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters. Mol. Endocrinol. 10 1478-87 PubMed GONUTS page