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MOUSE:MIPT3
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Traf3ip1 (synonyms: Ift54, Mipt3) | |
| Protein Name(s) | TRAF3-interacting protein 1
Intraflagellar transport protein 54 homolog Microtubule-interacting protein associated with TRAF3 MIP-T3 | |
| External Links | ||
| UniProt | Q149C2 | |
| EMBL | AY613437 BC046538 BC117868 AK014457 | |
| CCDS | CCDS35664.1 | |
| RefSeq | NP_082994.1 | |
| UniGene | Mm.318430 Mm.491399 | |
| ProteinModelPortal | Q149C2 | |
| SMR | Q149C2 | |
| MaxQB | Q149C2 | |
| PaxDb | Q149C2 | |
| PRIDE | Q149C2 | |
| Ensembl | ENSMUST00000047242 | |
| GeneID | 74019 | |
| KEGG | mmu:74019 | |
| UCSC | uc007cax.2 | |
| CTD | 26146 | |
| MGI | MGI:1921269 | |
| eggNOG | NOG304934 | |
| GeneTree | ENSGT00720000108822 | |
| HOGENOM | HOG000007159 | |
| HOVERGEN | HBG101388 | |
| InParanoid | Q149C2 | |
| OMA | NGEHSRD | |
| OrthoDB | EOG7BKCV3 | |
| PhylomeDB | Q149C2 | |
| TreeFam | TF315473 | |
| ChiTaRS | Traf3ip1 | |
| NextBio | 339550 | |
| PRO | PR:Q149C2 | |
| Proteomes | UP000000589 | |
| Bgee | Q149C2 | |
| Genevestigator | Q149C2 | |
| GO | GO:0005930 GO:0005813 GO:0036064 GO:0005929 GO:0030992 GO:0042384 GO:0031076 GO:0042733 GO:0035050 GO:0042073 GO:0050687 GO:0032688 GO:1901621 GO:0021532 GO:0036342 | |
| InterPro | IPR018799 | |
| PANTHER | PTHR31363 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0050687 |
negative regulation of defense response to virus |
ECO:0000315 |
P |
Fig. 7DEFG |
complete | |||||
|
involved_in |
GO:0070507 |
regulation of microtubule cytoskeleton organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001738 |
morphogenesis of a polarized epithelium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097546 |
ciliary base |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001822 |
kidney development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097542 |
ciliary tip |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035869 |
ciliary transition zone |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050687 |
negative regulation of defense response to virus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030992 |
intraciliary transport particle B |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030992 |
intraciliary transport particle B |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042073 |
intraciliary transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000773545 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030992 |
intraciliary transport particle B |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1921269 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005929 |
cilium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1921269 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1921269 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1901621 |
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4129326 |
P |
regulates_o_occurs_in:(EMAPA:16039) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0097546 |
ciliary base |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097542 |
ciliary tip |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070507 |
regulation of microtubule cytoskeleton organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060271 |
cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4129326 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051101 |
regulation of DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:AF242456 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050687 |
negative regulation of defense response to virus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050687 |
negative regulation of defense response to virus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042733 |
embryonic digit morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4129326 |
P |
has_participant:(EMAPA:17428) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0042532 |
negative regulation of tyrosine phosphorylation of STAT protein |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:AF242456 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042073 |
intraciliary transport |
ECO:0000305 |
curator inference used in manual assertion |
GO:0030992 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0036342 |
post-anal tail morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4129326 |
P |
has_participant:(EMAPA:16748) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0036064 |
ciliary basal body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035869 |
ciliary transition zone |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035050 |
embryonic heart tube development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4129326 |
P |
results_in_development_of:(EMAPA:16105) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0032688 |
negative regulation of interferon-beta production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032480 |
negative regulation of type I interferon production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031333 |
negative regulation of protein complex assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031076 |
embryonic camera-type eye development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4129326 |
P |
results_in_development_of:(EMAPA:16198) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0030992 |
intraciliary transport particle B |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0021532 |
neural tube patterning |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4129326 |
P |
occurs_in:(EMAPA:16039) |
Seeded From UniProt |
complete | |
|
enables |
GO:0015631 |
tubulin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:AF230877 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0015630 |
microtubule cytoskeleton |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:AF230877 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008017 |
microtubule binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:AF230877 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005930 |
axoneme |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005929 |
cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:AF230877 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:AF242456 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001933 |
negative regulation of protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001822 |
kidney development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001738 |
morphogenesis of a polarized epithelium |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
EMBL:AF242456 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0097546 |
ciliary base |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8TDR0 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0097542 |
ciliary tip |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8TDR0 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070507 |
regulation of microtubule cytoskeleton organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8TDR0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050687 |
negative regulation of defense response to virus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8TDR0 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035869 |
ciliary transition zone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8TDR0 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032480 |
negative regulation of type I interferon production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8TDR0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031333 |
negative regulation of protein complex assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8TDR0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001933 |
negative regulation of protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8TDR0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001822 |
kidney development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8TDR0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001738 |
morphogenesis of a polarized epithelium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8TDR0 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008017 |
microtubule binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005929 |
cilium |
Reactome:R-MMU-5617824 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005929 |
cilium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030030 |
cell projection organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Ng, MH et al. (2011) MIP-T3 is a negative regulator of innate type I IFN response. J. Immunol. 187 6473-82 PubMed GONUTS page
- ↑ 2.0 2.1 Bizet, AA et al. (2015) Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization. Nat Commun 6 8666 PubMed GONUTS page
- ↑ Liew, GM et al. (2014) The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Dev. Cell 31 265-78 PubMed GONUTS page
- ↑ Ishikawa, H et al. (2014) TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Elife 3 e01566 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 Berbari, NF et al. (2011) Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation. Dev. Biol. 360 66-76 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Follit, JA et al. (2009) Characterization of mouse IFT complex B. Cell Motil. Cytoskeleton 66 457-68 PubMed GONUTS page
c
- GO:0042995 ! cell projection
- GO:0030030 ! cell projection organization
- GO:0005813 ! centrosome
- Chordata
- GO:0036064 ! ciliary basal body
- GO:0097546 ! ciliary base
- GO:0097542 ! ciliary tip
- GO:0035869 ! ciliary transition zone
- GO:0005929 ! cilium
- GO:0060271 ! cilium assembly
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
e
g
m
n
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0031333 ! negative regulation of protein-containing complex assembly
- GO:1901621 ! negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
- GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
- GO:0032688 ! negative regulation of interferon-beta production
- GO:0001933 ! negative regulation of protein phosphorylation
- GO:0032480 ! negative regulation of type I interferon production
- GO:0050687 ! negative regulation of defense response to virus
- GO:0021532 ! neural tube patterning
r
