MOUSE:MARK4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mark4 (synonyms: Kiaa1860)
Protein Name(s)	MAP/microtubule affinity-regulating kinase 4
External Links
UniProt	Q8CIP4
EMBL	AY151083 AK122565
CCDS	CCDS20903.1
RefSeq	NP_758483.1
UniGene	Mm.260504
ProteinModelPortal	Q8CIP4
SMR	Q8CIP4
BioGrid	231328
DIP	DIP-60721N
PhosphoSite	Q8CIP4
MaxQB	Q8CIP4
PaxDb	Q8CIP4
PRIDE	Q8CIP4
DNASU	232944
Ensembl	ENSMUST00000085715
GeneID	232944
KEGG	mmu:232944
UCSC	uc009flx.1
CTD	57787
MGI	MGI:1920955
eggNOG	COG0515
GeneTree	ENSGT00760000118892
HOGENOM	HOG000233025
HOVERGEN	HBG052453
InParanoid	Q8CIP4
KO	K08798
OMA	DSMSTPN
OrthoDB	EOG79CXXX
PhylomeDB	Q8CIP4
TreeFam	TF315213
NextBio	381357
PRO	PR:Q8CIP4
Proteomes	UP000000589
Bgee	Q8CIP4
CleanEx	MM_MARK4
ExpressionAtlas	Q8CIP4
Genevestigator	Q8CIP4
GO	GO:0005813 GO:0015630 GO:0005815 GO:0043005 GO:0005524 GO:0043015 GO:0008017 GO:0004674 GO:0050321 GO:0001578 GO:0000226 GO:0007399
Gene3D	3.30.310.80
InterPro	IPR028375 IPR001772 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 IPR015940 IPR000449
Pfam	PF02149 PF00069 PF00627
SMART	SM00220 SM00165
SUPFAM	SSF103243 SSF56112
PROSITE	PS50032 PS00107 PS50011 PS00108 PS50030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	P	Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	F	Seeded From UniProt	complete
enables	GO:0043015	gamma-tubulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	F	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	F	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	P	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	F	Seeded From UniProt	complete
involved_in	GO:0001578	microtubule bundle formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	P	Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96L34	P	Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260934 PANTHER:PTN000680111 RGD:619882 RGD:708483 UniProtKB:Q96L34	F	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002519176 RGD:619882 UniProtKB:Q7KZI7 UniProtKB:Q9P0L2	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038167 MGI:MGI:2446296 PANTHER:PTN002519176 RGD:619882 SGD:S000000015 UniProtKB:P27448 UniProtKB:Q7KZI7 UniProtKB:Q96L34 UniProtKB:Q96RG2 UniProtKB:Q9P0L2 WB:WBGene00003916	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260934 PANTHER:PTN002519176 RGD:619882 RGD:708483 SGD:S000000015 SGD:S000005405 UniProtKB:A0A1D8PN61 UniProtKB:P27448 UniProtKB:Q7KZI7 UniProtKB:Q93V58 UniProtKB:Q96L34 UniProtKB:Q96RG2 UniProtKB:Q9P0L2 UniProtKB:Q9Y2K2 WB:WBGene00003916	F	Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260934 PANTHER:PTN000680111 RGD:619882 UniProtKB:Q96L34	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904781	positive regulation of protein localization to centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	P	Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046605	regulation of centrosome cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045724	positive regulation of cilium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044782	cilium organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	P	Seeded From UniProt	complete
enables	GO:0043015	gamma-tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	F	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	P	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007399	nervous system development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	P	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	F	Seeded From UniProt	complete
part_of	GO:0000930	gamma-tubulin complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96L34	C	Seeded From UniProt	complete
involved_in	GO:1904781	positive regulation of protein localization to centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	P	Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	F	Seeded From UniProt	complete
involved_in	GO:0046605	regulation of centrosome cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	P	Seeded From UniProt	complete
involved_in	GO:0045724	positive regulation of cilium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	P	Seeded From UniProt	complete
involved_in	GO:0044782	cilium organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	P	Seeded From UniProt	complete
enables	GO:0043015	gamma-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	F	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	C	Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	C	Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	C	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	F	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	P	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	F	Seeded From UniProt	complete
involved_in	GO:0001578	microtubule bundle formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	P	Seeded From UniProt	complete
part_of	GO:0000930	gamma-tubulin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	C	Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96L34 ensembl:ENSP00000262891	P	Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033624	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033624	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P	Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033624	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:MARK4

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Annotations

Notes

References

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