MOUSE:LPP1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ppap2a (synonyms: Hpic53, Lpp1)
Protein Name(s)	Lipid phosphate phosphohydrolase 1 35 kDa PAP mPAP Hydrogen peroxide-inducible protein 53 Hic53 PAP2-alpha Phosphatidate phosphohydrolase type 2a Phosphatidic acid phosphatase 2a PAP-2a PAP2a
External Links
UniProt	Q61469
EMBL	L43371 D84376 AY247795 AY247796 AK077275 BC061161
CCDS	CCDS26776.1 CCDS26777.1
PIR	S66668
RefSeq	NP_032273.1 NP_032929.1
UniGene	Mm.317186
ProteinModelPortal	Q61469
IntAct	Q61469
PhosphoSite	Q61469
MaxQB	Q61469
PaxDb	Q61469
PRIDE	Q61469
Ensembl	ENSMUST00000016144 ENSMUST00000070951
GeneID	19012
KEGG	mmu:19012
UCSC	uc007rwq.1 uc007rwr.1
CTD	8611
MGI	MGI:108412
eggNOG	COG0671
GeneTree	ENSGT00620000087654
HOGENOM	HOG000041307
HOVERGEN	HBG002048
InParanoid	Q61469
KO	K01080
OMA	FMNYEIP
OrthoDB	EOG7C5M9Q
PhylomeDB	Q61469
TreeFam	TF316040
Reactome	REACT_198151
ChiTaRS	Ppap2a
NextBio	295422
PRO	PR:Q61469
Proteomes	UP000000589
Bgee	Q61469
CleanEx	MM_PPAP2A
ExpressionAtlas	Q61469
Genevestigator	Q61469
GO	GO:0070062 GO:0005887 GO:0016020 GO:0005886 GO:0008195 GO:0006672 GO:0006651 GO:0006470 GO:0007165 GO:0006670
Gene3D	1.20.144.10
InterPro	IPR028670 IPR000326
PANTHER	PTHR10165:SF26
Pfam	PF01569
SMART	SM00014
SUPFAM	SSF48317

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14494	C	Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14494	F	Seeded From UniProt	complete
involved_in	GO:0046839	phospholipid dephosphorylation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001606015 RGD:727806 UniProtKB:O14494 UniProtKB:Q5VZY2 UniProtKB:Q8NEB5	P	Seeded From UniProt	complete
enables	GO:0042577	lipid phosphatase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0041087 MGI:MGI:1915166 PANTHER:PTN000807400 RGD:727806 UniProtKB:O14494	F	Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0016078 PANTHER:PTN001606015	F	Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108412 PANTHER:PTN000017950 SGD:S000002692 SGD:S000002911 TAIR:locus:2037758 UniProtKB:O14494 UniProtKB:Q5VZY2 UniProtKB:Q8NEB5	F	Seeded From UniProt	complete
involved_in	GO:0006644	phospholipid metabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915166 PANTHER:PTN001606015	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001606015 RGD:727806	C	Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	PMID:8702556^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	PMID:8702556^[2]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
acts_upstream_of_or_within	GO:0006470	protein dephosphorylation	PMID:8702556^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046839	phospholipid dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14494 ensembl:ENSP00000264775	P	Seeded From UniProt	complete
enables	GO:0042577	lipid phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14494 ensembl:ENSP00000264775	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14494 ensembl:ENSP00000264775	C	Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14494 ensembl:ENSP00000264775	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028670	C	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028670	P	Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028670	F	Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.4	F	Seeded From UniProt	complete
enables	GO:0008195	phosphatidate phosphatase activity	PMID:9733709^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	PMID:9733709^[3] PMID:8702556^[2] PMID:10425403^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006672	ceramide metabolic process	PMID:10425403^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006670	sphingosine metabolic process	PMID:10425403^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006651	diacylglycerol biosynthetic process	PMID:8702556^[2] PMID:10425403^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006470	protein dephosphorylation	PMID:9733709^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10425403^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9733709^[3] PMID:8702556^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Kai, M et al. (1996) Identification and cDNA cloning of 35-kDa phosphatidic acid phosphatase (type 2) bound to plasma membranes. Polymerase chain reaction amplification of mouse H2O2-inducible hic53 clone yielded the cDNA encoding phosphatidic acid phosphatase. J. Biol. Chem. 271 18931-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Brindley, DN & Waggoner, DW (1998) Mammalian lipid phosphate phosphohydrolases. J. Biol. Chem. 273 24281-4 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Waggoner, DW et al. (1999) Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction. Biochim. Biophys. Acta 1439 299-316 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8702556-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Kai, M et al. (1996) Identification and cDNA cloning of 35-kDa phosphatidic acid phosphatase (type 2) bound to plasma membranes. Polymerase chain reaction amplification of mouse H2O2-inducible hic53 clone yielded the cDNA encoding phosphatidic acid phosphatase. J. Biol. Chem. 271 18931-8 PubMed GONUTS page

[PMID:9733709-3] 3.0 ^3.1 ^3.2 ^3.3 Brindley, DN & Waggoner, DW (1998) Mammalian lipid phosphate phosphohydrolases. J. Biol. Chem. 273 24281-4 PubMed GONUTS page

[PMID:10425403-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Waggoner, DW et al. (1999) Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction. Biochim. Biophys. Acta 1439 299-316 PubMed GONUTS page

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MOUSE:LPP1

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