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MOUSE:LDHC

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ldhc (synonyms: Ldh-3, Ldh3)
Protein Name(s) L-lactate dehydrogenase C chain

LDH-C LDH testis subunit LDH-X

External Links
UniProt P00342
EMBL X04752
M17587
BC049602
M12781
CCDS CCDS21290.1
PIR A26824
RefSeq NP_038608.1
XP_006540742.1
XP_006540743.1
XP_006540744.1
UniGene Mm.16563
PDB 2LDX
PDBsum 2LDX
ProteinModelPortal P00342
SMR P00342
IntAct P00342
MINT MINT-6611882
PhosphoSite P00342
REPRODUCTION-2DPAGE P00342
PaxDb P00342
PRIDE P00342
Ensembl ENSMUST00000014545
GeneID 16833
KEGG mmu:16833
UCSC uc009gzp.1
CTD 3948
MGI MGI:96764
eggNOG COG0039
HOGENOM HOG000213793
HOVERGEN HBG000462
InParanoid P00342
KO K00016
OMA RCKITVV
OrthoDB EOG7X0VH3
PhylomeDB P00342
TreeFam TF314963
UniPathway UPA00554
ChiTaRS Ldhc
EvolutionaryTrace P00342
NextBio 290746
PRO PR:P00342
Proteomes UP000000589
Bgee P00342
CleanEx MM_LDHC
ExpressionAtlas P00342
Genevestigator P00342
GO GO:0005929
GO:0005737
GO:0031514
GO:0005634
GO:0004459
GO:0006754
GO:0044262
GO:0019244
GO:0019516
GO:0006090
GO:0030317
Gene3D 3.40.50.720
3.90.110.10
HAMAP MF_00488
InterPro IPR001557
IPR011304
IPR018177
IPR022383
IPR001236
IPR015955
IPR016040
PANTHER PTHR11540
Pfam PF02866
PF00056
PIRSF PIRSF000102
PRINTS PR00086
SUPFAM SSF56327
TIGRFAMs TIGR01771
PROSITE PS00064

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

acts_upstream_of_or_within

GO:0019244

lactate biosynthetic process from pyruvate

PMID:18367675[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006754

ATP biosynthetic process

PMID:18367675[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3775042

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006090

pyruvate metabolic process

PMID:18367675[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:16687649[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18367675[1]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000586)|part_of:(CL:0000586)

Seeded From UniProt

complete

enables

GO:0004459

L-lactate dehydrogenase activity

PMID:18367675[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3775042

F

Seeded From UniProt

complete

part_of

GO:0031514

motile cilium

PMID:18367675[1]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030317

flagellated sperm motility

PMID:18367675[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3775042

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019516

lactate oxidation

PMID:18367675[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015955

F

Seeded From UniProt

complete

enables

GO:0004459

L-lactate dehydrogenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011304
InterPro:IPR018177

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011304

C

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015955

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001236

F

Seeded From UniProt

complete

enables

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001557
InterPro:IPR015955
InterPro:IPR022383

F

Seeded From UniProt

complete

involved_in

GO:0019752

carboxylic acid metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001557

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001236
InterPro:IPR001557
InterPro:IPR011304
InterPro:IPR015955
InterPro:IPR018177
InterPro:IPR022383

P

Seeded From UniProt

complete

enables

GO:0004459

L-lactate dehydrogenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.27

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Odet, F et al. (2008) Expression of the gene for mouse lactate dehydrogenase C (Ldhc) is required for male fertility. Biol. Reprod. 79 26-34 PubMed GONUTS page
  2. Krisfalusi, M et al. (2006) Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa. Biol. Reprod. 75 270-8 PubMed GONUTS page