MOUSE:KGP1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Prkg1 (synonyms: Prkg1b, Prkgr1a, Prkgr1b)
Protein Name(s)	cGMP-dependent protein kinase 1 cGK 1 cGK1 cGMP-dependent protein kinase I cGKI
External Links
UniProt	P0C605
EMBL	AF084547 AC102751 AC103405 AC108399 AC116507 AC119158 AC122548 BC113162
CCDS	CCDS29745.1
RefSeq	NP_001013855.1 NP_035290.1 XP_006526831.1
UniGene	Mm.381170
ProteinModelPortal	P0C605
SMR	P0C605
BioGrid	202372
DIP	DIP-29981N
IntAct	P0C605
MINT	MINT-7289393
PhosphoSite	P0C605
MaxQB	P0C605
PaxDb	P0C605
PRIDE	P0C605
Ensembl	ENSMUST00000065067 ENSMUST00000073581
GeneID	19091
KEGG	mmu:19091
UCSC	uc008heo.2 uc008hep.2
CTD	5592
MGI	MGI:108174
eggNOG	COG0664
GeneTree	ENSGT00770000120454
HOGENOM	HOG000233033
HOVERGEN	HBG006211
InParanoid	P0C605
KO	K07376
OrthoDB	EOG75B84Q
PhylomeDB	P0C605
TreeFam	TF313261
Reactome	REACT_221970 REACT_229620 REACT_237855
ChiTaRS	Prkg1
NextBio	295648
PRO	PR:P0C605
Proteomes	UP000000589
Bgee	P0C605
CleanEx	MM_PRKG1
ExpressionAtlas	P0C605
Genevestigator	P0C605
GO	GO:0005737 GO:0005794 GO:0005886 GO:0005524 GO:0005246 GO:0030553 GO:0004692 GO:0004672 GO:0019934 GO:0016358 GO:0030900 GO:0090331 GO:0045986 GO:0001764 GO:0006468 GO:0043087 GO:0060087 GO:0007165
Gene3D	2.60.120.10
InterPro	IPR000961 IPR016232 IPR002374 IPR018490 IPR018488 IPR000595 IPR011009 IPR000719 IPR017441 IPR014710 IPR002290 IPR008271
Pfam	PF00027 PF00069
PIRSF	PIRSF000559
PRINTS	PR00104
SMART	SM00100 SM00133 SM00220
SUPFAM	SSF51206 SSF56112
PROSITE	PS51285 PS00888 PS00889 PS50042 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005829	cytosol	PMID:19127022^[1]	ECO:0000314			C		Figure 7B: Immunohistochemistry shows PKG1-alpha localises to cytosol (striated pattern).	complete
	GO:0009279	cell outer membrane	PMID:19127022^[1]	ECO:0000314			C		Figure 7B-D: Immunohistochemistry shows PKG1-alpha protein in outer membrane.	complete
	GO:0090004	positive regulation of establishment of protein localization in plasma membrane	PMID:19127022^[1]	ECO:0000314			P		Figure 7: PKG1-alpha outer membrane localization occurs with RGS2 membrane localization	complete
part_of	GO:0005886	plasma membrane	PMID:19127022^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090331	negative regulation of platelet aggregation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13976	P		Seeded From UniProt	complete
involved_in	GO:0043087	regulation of GTPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13976	P		Seeded From UniProt	complete
enables	GO:0030553	cGMP binding	PMID:10671526^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10671526^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:10671526^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:10671526^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13976	C		Seeded From UniProt	complete
enables	GO:0005246	calcium channel regulator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13976	F		Seeded From UniProt	complete
enables	GO:0004692	cGMP-dependent protein kinase activity	PMID:10671526^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10671526^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000224	regulation of testosterone biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902608	positive regulation of large conductance calcium-activated potassium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090331	negative regulation of platelet aggregation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061049	cell growth involved in cardiac muscle cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060087	relaxation of vascular smooth muscle	PMID:15483626^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181586	P	occurs_in:(EMAPA:35135)	Seeded From UniProt	complete
enables	GO:0048273	mitogen-activated protein kinase p38 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045986	negative regulation of smooth muscle contraction	PMID:15483626^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181586	P	occurs_in:(EMAPA:35443)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045822	negative regulation of heart contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043087	regulation of GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13976	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13976	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042753	positive regulation of circadian rhythm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:16154207^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181586	P	results_in_development_of:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019934	cGMP-mediated signaling	PMID:15483626^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181586	P	occurs_in:(EMAPA:35443)\|occurs_in:(EMAPA:35135)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016358	dendrite development	PMID:16154207^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181586	P	occurs_in:(EMAPA:17544) occurs_in:(CL:0000598)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014912	negative regulation of smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014050	negative regulation of glutamate secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010920	negative regulation of inositol phosphate biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13976	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13976	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	C		Seeded From UniProt	complete
enables	GO:0005246	calcium channel regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13976	F		Seeded From UniProt	complete
enables	GO:0004692	cGMP-dependent protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13976	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:15465019^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13976	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:16154207^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181586	P	occurs_in:(EMAPA:17544) results_in_movement_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0001669	acrosomal vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1587390	C		Seeded From UniProt	complete
involved_in	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13976 ensembl:ENSP00000363092	P		Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13976 ensembl:ENSP00000363092	P		Seeded From UniProt	complete
involved_in	GO:0090331	negative regulation of platelet aggregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13976 ensembl:ENSP00000363092	P		Seeded From UniProt	complete
involved_in	GO:0043087	regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13976 ensembl:ENSP00000363092	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13976 ensembl:ENSP00000363092	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13976 ensembl:ENSP00000363092	C		Seeded From UniProt	complete
enables	GO:0005246	calcium channel regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13976 ensembl:ENSP00000363092	F		Seeded From UniProt	complete
enables	GO:0004692	cGMP-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13976 ensembl:ENSP00000363092	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13976 ensembl:ENSP00000363092	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961	F		Seeded From UniProt	complete
enables	GO:0004692	cGMP-dependent protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002374 InterPro:IPR035014	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR002374 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0004692	cGMP-dependent protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.12	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16990611^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:22922339^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P70460) has_output:(PR:000044496)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:22922339^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P70460) has_output:(PR:000044496)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16990611^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0030553	cGMP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0142	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Takimoto, E et al. (2009) Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J. Clin. Invest. 119 408-20 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Yuasa, K et al. (2000) Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. J. Biol. Chem. 275 4897-905 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Geiselhöringer, A et al. (2004) IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase. EMBO J. 23 4222-31 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Demyanenko, GP et al. (2005) Abnormal neocortical development in mice lacking cGMP-dependent protein kinase I. Brain Res. Dev. Brain Res. 160 1-8 PubMed GONUTS page
↑ Keicher, C et al. (2004) Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. Biochem. Biophys. Res. Commun. 324 308-16 PubMed GONUTS page
↑ ^6.0 ^6.1 Antl, M et al. (2007) IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Blood 109 552-9 PubMed GONUTS page
↑ ^7.0 ^7.1 Müller, PM et al. (2012) H₂O₂ lowers the cytosolic Ca²⁺ concentration via activation of cGMP-dependent protein kinase Iα. Free Radic. Biol. Med. 53 1574-83 PubMed GONUTS page

[PMID:19127022-1] 1.0 ^1.1 ^1.2 ^1.3 Takimoto, E et al. (2009) Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J. Clin. Invest. 119 408-20 PubMed GONUTS page

[PMID:10671526-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Yuasa, K et al. (2000) Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. J. Biol. Chem. 275 4897-905 PubMed GONUTS page

[PMID:15483626-3] 3.0 ^3.1 ^3.2 Geiselhöringer, A et al. (2004) IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase. EMBO J. 23 4222-31 PubMed GONUTS page

[PMID:16154207-4] 4.0 ^4.1 ^4.2 Demyanenko, GP et al. (2005) Abnormal neocortical development in mice lacking cGMP-dependent protein kinase I. Brain Res. Dev. Brain Res. 160 1-8 PubMed GONUTS page

[PMID:15465019-5] Keicher, C et al. (2004) Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. Biochem. Biophys. Res. Commun. 324 308-16 PubMed GONUTS page

[PMID:16990611-6] 6.0 ^6.1 Antl, M et al. (2007) IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Blood 109 552-9 PubMed GONUTS page

[PMID:22922339-7] 7.0 ^7.1 Müller, PM et al. (2012) H₂O₂ lowers the cytosolic Ca²⁺ concentration via activation of cGMP-dependent protein kinase Iα. Free Radic. Biol. Med. 53 1574-83 PubMed GONUTS page

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MOUSE:KGP1

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