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MOUSE:KCNQ3
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Kcnq3 | |
| Protein Name(s) | Potassium voltage-gated channel subfamily KQT member 3
KQT-like 3 Potassium channel subunit alpha KvLQT3 Voltage-gated potassium channel subunit Kv7.3 | |
| External Links | ||
| UniProt | Q8K3F6 | |
| EMBL | AY118171 AC091276 AC102633 AC110897 AC125054 | |
| CCDS | CCDS49619.1 | |
| RefSeq | NP_690887.2 | |
| UniGene | Mm.255585 | |
| ProteinModelPortal | Q8K3F6 | |
| BioGrid | 225968 | |
| IntAct | Q8K3F6 | |
| STRING | 10090.ENSMUSP00000063380 | |
| iPTMnet | Q8K3F6 | |
| PhosphoSitePlus | Q8K3F6 | |
| PaxDb | Q8K3F6 | |
| PRIDE | Q8K3F6 | |
| Ensembl | ENSMUST00000070256 | |
| GeneID | 110862 | |
| KEGG | mmu:110862 | |
| UCSC | uc007wab.2 | |
| CTD | 3786 | |
| MGI | MGI:1336181 | |
| eggNOG | KOG1419 COG1226 | |
| GeneTree | ENSGT00550000074513 | |
| HOGENOM | HOG000220839 | |
| HOVERGEN | HBG059014 | |
| InParanoid | Q8K3F6 | |
| KO | K04928 | |
| OMA | FFAHDPV | |
| OrthoDB | EOG091G02ZT | |
| TreeFam | TF315186 | |
| Reactome | [www.reactome.org/content/detail/R-MMU-1296072 R-MMU-1296072] | |
| PRO | PR:Q8K3F6 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000056258 | |
| Genevisible | Q8K3F6 | |
| GO | GO:0043194 GO:0009986 GO:0033268 GO:0005886 GO:0008076 GO:0005516 GO:0005267 GO:0005244 GO:0005249 GO:0060081 GO:0071805 | |
| InterPro | IPR020969 IPR005821 IPR003937 IPR003948 IPR013821 IPR028325 | |
| PANTHER | PTHR11537 PTHR11537:SF174 | |
| Pfam | PF00520 PF03520 PF11956 | |
| PRINTS | PR00169 PR01462 PR01459 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045163 |
clustering of voltage-gated potassium channels |
ECO:0000314 |
P |
KCNQ3 forms clusters of voltage-gated potassium channels with KCNQ2, as seen in Figure 3A-D. UniProt Nomenclature: Potassium voltage-gated channel subfamily KQT member 3 (KCNQ3_MOUSE) UniProt ID: Q8K3F6 Organism: Mus musculus |
complete | |||||
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043194 |
axon initial segment |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033268 |
node of Ranvier |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:102663 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043194 |
axon initial segment |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1336181 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003380 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003380 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1309503 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005251 |
delayed rectifier potassium channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000899150 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108083 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3830636 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071242 |
cellular response to ammonium ion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060081 |
membrane hyperpolarization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3830636 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044325 |
ion channel binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043194 |
axon initial segment |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0036477 |
somatodendritic compartment |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0034220 |
ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1309503 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005267 |
potassium channel activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3830636 |
F |
|
Seeded From UniProt |
complete | |
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69222 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005244 |
voltage-gated ion channel activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1309503 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O43525 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O43525 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O43525 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O43525 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O43525 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005216 |
ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005267 |
potassium channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006813 |
potassium ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR003937 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0055085 |
transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034765 |
regulation of ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005267 |
potassium channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006813 |
potassium ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005244 |
voltage-gated ion channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Zhang, J et al. (2016) Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons. Neuron 92 461-478 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Pan, Z et al. (2006) A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. J. Neurosci. 26 2599-613 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Tzingounis, AV & Nicoll, RA (2008) Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents. Proc. Natl. Acad. Sci. U.S.A. 105 19974-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Wen, H & Levitan, IB (2002) Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels. J. Neurosci. 22 7991-8001 PubMed GONUTS page
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