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MOUSE:KCC2B
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Camk2b (synonyms: Camk2d) | |
| Protein Name(s) | Calcium/calmodulin-dependent protein kinase type II subunit beta
CaM kinase II subunit beta CaMK-II subunit beta | |
| External Links | ||
| UniProt | P28652 | |
| EMBL | X63615 AK163698 AL611926 AL645469 AL645469 AL611926 | |
| CCDS | CCDS24411.1 | |
| PIR | A45025 | |
| RefSeq | NP_031621.3 | |
| UniGene | Mm.439733 | |
| ProteinModelPortal | P28652 | |
| SMR | P28652 | |
| BioGrid | 198462 | |
| DIP | DIP-31582N | |
| IntAct | P28652 | |
| MINT | MINT-136473 | |
| PhosphoSite | P28652 | |
| MaxQB | P28652 | |
| PaxDb | P28652 | |
| PRIDE | P28652 | |
| Ensembl | ENSMUST00000109813 ENSMUST00000109815 | |
| GeneID | 12323 | |
| KEGG | mmu:12323 | |
| UCSC | uc007hxr.2 | |
| CTD | 816 | |
| MGI | MGI:88257 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00760000118944 | |
| HOGENOM | HOG000233016 | |
| HOVERGEN | HBG108055 | |
| InParanoid | P28652 | |
| KO | K04515 | |
| OrthoDB | EOG7ZD1VM | |
| TreeFam | TF315229 | |
| BRENDA | 2.7.11.17 | |
| Reactome | REACT_198244 REACT_198246 REACT_198248 REACT_198660 REACT_213550 REACT_258217 | |
| ChiTaRS | Camk2b | |
| NextBio | 280904 | |
| PRO | PR:P28652 | |
| Proteomes | UP000000589 | |
| Bgee | P28652 | |
| ExpressionAtlas | P28652 | |
| Genevestigator | P28652 | |
| GO | GO:0005829 GO:0005815 GO:0097481 GO:0033017 GO:0051233 GO:0005524 GO:0004683 GO:0004674 GO:0060466 GO:0006816 GO:0000082 GO:0002030 GO:0050885 GO:0018105 GO:2001235 GO:0061003 GO:0010976 GO:0090129 GO:0046777 GO:0048169 GO:0032222 GO:0046686 | |
| InterPro | IPR020636 IPR013543 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 | |
| PANTHER | PTHR24347 | |
| Pfam | PF08332 PF00069 | |
| SMART | SM00220 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:2001222 |
regulation of neuron migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090129 |
positive regulation of synapse maturation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061003 |
positive regulation of dendritic spine morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010976 |
positive regulation of neuron projection development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002389359 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1341265 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88256 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004683 |
calmodulin-dependent protein kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0264607 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2001235 |
positive regulation of apoptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2001222 |
regulation of neuron migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1903076 |
regulation of protein localization to plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0098973 |
structural constituent of postsynaptic actin cytoskeleton |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090129 |
positive regulation of synapse maturation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0061003 |
positive regulation of dendritic spine morphogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060466 |
activation of meiosis involved in egg activation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0000025) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060291 |
long-term synaptic potentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0051233 |
spindle midzone |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000025) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050885 |
neuromuscular process controlling balance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4359775 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048858 |
cell projection morphogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048169 |
regulation of long-term neuronal synaptic plasticity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4359775 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0046777 |
protein autophosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046777 |
protein autophosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046686 |
response to cadmium ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043274 |
phospholipase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043204 |
perikaryon |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032430 |
positive regulation of phospholipase A2 activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032222 |
regulation of synaptic transmission, cholinergic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_participant:(MGI:MGI:88398) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010976 |
positive regulation of neuron projection development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006816 |
calcium ion transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000025) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004683 |
calmodulin-dependent protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004683 |
calmodulin-dependent protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2262 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(MGI:MGI:88398) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0002030 |
inhibitory G protein-coupled receptor phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_input:(MGI:MGI:88398) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0000082 |
G1/S transition of mitotic cell cycle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0098974 |
postsynaptic actin cytoskeleton organization |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0098973 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004683 |
calmodulin-dependent protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004683 |
calmodulin-dependent protein kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016529 |
sarcoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033017 |
sarcoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Küry, S et al. (2017) De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. Am. J. Hum. Genet. 101 768-788 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 Liu, Y & Templeton, DM (2007) Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells. FEBS Lett. 581 1481-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Johnson, J et al. (1998) Calcium/calmodulin-dependent protein kinase II and calmodulin: regulators of the meiotic spindle in mouse eggs. Dev. Biol. 204 464-77 PubMed GONUTS page
- ↑ 5.0 5.1 van Woerden, GM et al. (2009) betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses. Nat. Neurosci. 12 823-5 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Afroze, T et al. (2003) Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle. Am. J. Physiol., Cell Physiol. 285 C88-95 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Butcher, AJ et al. (2009) N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons. J. Biol. Chem. 284 17147-56 PubMed GONUTS page
- ↑ Munton, RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol. Cell Proteomics 6 283-93 PubMed GONUTS page
c
- GO:0004683 ! calcium/calmodulin-dependent protein kinase activity
- GO:0006816 ! calcium ion transport
- GO:0005516 ! calmodulin binding
- GO:0030154 ! cell differentiation
- GO:0030054 ! cell junction
- GO:0048858 ! cell projection morphogenesis
- Chordata
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
i
m
n
p
- GO:0018105 ! peptidyl-serine phosphorylation
- GO:0043204 ! perikaryon
- GO:0043274 ! phospholipase binding
- GO:0016310 ! phosphorylation
- GO:0090129 ! positive regulation of synapse maturation
- GO:2001235 ! positive regulation of apoptotic signaling pathway
- GO:0010976 ! positive regulation of neuron projection development
- GO:0061003 ! positive regulation of dendritic spine morphogenesis
- GO:0032430 ! positive regulation of phospholipase A2 activity
- GO:0098974 ! postsynaptic actin cytoskeleton organization
- GO:0014069 ! postsynaptic density
- GO:0046777 ! protein autophosphorylation
- GO:0042803 ! protein homodimerization activity
- GO:0004672 ! protein kinase activity
- GO:0019901 ! protein kinase binding
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
r
s
