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MOUSE:K22E
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Krt2 (ECO:0000312 with EMBL:AAI20486.1) | |
| Protein Name(s) | Keratin, type II cytoskeletal 2 epidermal
Cytokeratin-2e CK-2e Epithelial keratin-2e Keratin-2 epidermis Keratin-2e K2e Type-II keratin Kb2 | |
| External Links | ||
| UniProt | Q3TTY5 | |
| EMBL | X74784 AK132476 AK161078 AK161098 BC120485 | |
| CCDS | CCDS37220.1 | |
| RefSeq | NP_034798.2 | |
| UniGene | Mm.358616 | |
| ProteinModelPortal | Q3TTY5 | |
| SMR | Q3TTY5 | |
| BioGrid | 201033 | |
| IntAct | Q3TTY5 | |
| MINT | MINT-1867051 | |
| STRING | 10090.ENSMUSP00000023712 | |
| PhosphoSite | Q3TTY5 | |
| MaxQB | Q3TTY5 | |
| PaxDb | Q3TTY5 | |
| PRIDE | Q3TTY5 | |
| Ensembl | ENSMUST00000023712 | |
| GeneID | 16681 | |
| KEGG | mmu:16681 | |
| UCSC | uc007xub.1 | |
| CTD | 3849 | |
| MGI | MGI:96699 | |
| eggNOG | NOG146769 | |
| GeneTree | ENSGT00760000118796 | |
| HOVERGEN | HBG013015 | |
| InParanoid | Q3TTY5 | |
| KO | K07605 | |
| OMA | TNLDPIF | |
| OrthoDB | EOG7FV3Q8 | |
| TreeFam | TF317854 | |
| NextBio | 290429 | |
| PRO | PR:Q3TTY5 | |
| Proteomes | UP000000589 | |
| Bgee | Q3TTY5 | |
| CleanEx | MM_KRT2 | |
| Genevestigator | Q3TTY5 | |
| GO | GO:0005615 GO:0070062 GO:0005794 GO:0045095 GO:0016020 GO:0005634 GO:0005198 GO:0031424 GO:0032980 GO:0051546 GO:0043616 | |
| InterPro | IPR001664 IPR018039 IPR003054 | |
| PANTHER | PTHR23239 | |
| Pfam | PF00038 | |
| PRINTS | PR01276 | |
| PROSITE | PS00226 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005856 |
cytoskeleton |
ECO:0000314 |
C |
Figure 6. |
complete | |||||
|
involved_in |
GO:0045684 |
positive regulation of epidermis development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008092 |
cytoskeletal protein binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4363845 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005198 |
structural molecule activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4363845 |
F |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0003334 |
keratinocyte development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4363845 |
P |
occurs_in:(EMAPA:35315)|occurs_in:(EMAPA:17589) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0045109 |
intermediate filament organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4363845 |
P |
|
Seeded From UniProt |
complete | |
|
part_of |
GO:0045095 |
keratin filament |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008544 |
epidermis development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4363845 |
P |
|
Seeded From UniProt |
complete | |
|
involved_in |
GO:0051546 |
keratinocyte migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P35908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043616 |
keratinocyte proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P35908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032980 |
keratinocyte activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P35908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031424 |
keratinization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P35908 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030280 |
structural constituent of epidermis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P35908 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018149 |
peptide cross-linking |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P35908 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0001533 |
cornified envelope |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P35908 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005198 |
structural molecule activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005882 |
intermediate filament |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045095 |
keratin filament |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005882 |
intermediate filament |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ König, K et al. (2013) Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model. PLoS ONE 8 e57996 PubMed GONUTS page
- ↑ Fischer, H et al. (2016) Keratins K2 and K10 are essential for the epidermal integrity of plantar skin. J. Dermatol. Sci. 81 10-6 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Fischer, H et al. (2014) Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation. J. Invest. Dermatol. 134 2579-2588 PubMed GONUTS page
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