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MOUSE:INAR1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ifnar1 (synonyms: Ifar, Ifnar)
Protein Name(s) Interferon alpha/beta receptor 1

IFN-R-1 IFN-alpha/beta receptor 1 Type I interferon receptor 1

External Links
UniProt P33896
EMBL M89641
AK132431
AK141630
CH466602
BC043935
BC052429
CCDS CCDS28326.1
PIR A45283
RefSeq NP_034638.2
UniGene Mm.502
PDB 3WCY
PDBsum 3WCY
ProteinModelPortal P33896
SMR P33896
IntAct P33896
MINT MINT-1513172
PhosphoSite P33896
PRIDE P33896
Ensembl ENSMUST00000023689
ENSMUST00000117748
ENSMUST00000123196
GeneID 15975
KEGG mmu:15975
UCSC uc007zxn.2
CTD 3454
MGI MGI:107658
eggNOG NOG43815
GeneTree ENSGT00530000063449
HOGENOM HOG000113067
HOVERGEN HBG052126
InParanoid P33896
KO K05130
OMA VYCVKAR
OrthoDB EOG73FQMD
Reactome REACT_198622
REACT_198627
ChiTaRS Ifnar1
NextBio 288748
PRO PR:P33896
Proteomes UP000000589
Bgee P33896
CleanEx MM_IFNAR1
ExpressionAtlas P33896
Genevestigator P33896
GO GO:0016021
GO:0005886
GO:0004904
GO:0019221
GO:0051607
GO:0032729
GO:0050718
GO:0050730
GO:0042110
GO:0045351
Gene3D 2.60.40.10
InterPro IPR003961
IPR013783
IPR016669
IPR015373
Pfam PF09294
PF01108
PIRSF PIRSF016567
SMART SM00060
SUPFAM SSF49265
PROSITE PS50853

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045893

positive regulation of transcription, DNA-templated

PMID:24598055[1]

ECO:0000315

P

Interferon alpha receptor 1 knockouts show no increase in three prime repair exonuclease 1 (Trex1) expression of mRNA to interferon alpha whereas comparison with WT stimulation there is an increased expression of Trex1 mRNA as shown in figure 2 A graph 1 and figure 4 B at 6 hours.

complete
CACAO 9652

GO:0032728

positive regulation of interferon-beta production

PMID:24598055[1]

ECO:0000315

P

Knockout of Interferon alpha receptor 1 had did not increase production of Interferon beta mRNA with stimulation of interferon Alpha whereas the WT showed an increase in production of IFN beta with IFN alpha stimulation these were demonstrated in figure 2A graph 2.

complete
CACAO 9653

involved_in

GO:0060337

type I interferon signaling pathway

PMID:27129230[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004904

interferon receptor activity

PMID:27129230[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:27129230[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

PMID:14532120[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004905

type I interferon receptor activity

PMID:14532120[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035457

cellular response to interferon-alpha

PMID:14532120[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:14532120[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

PMID:23872679[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

PMID:23872679[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004905

type I interferon receptor activity

PMID:23872679[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019962

type I interferon binding

PMID:23872679[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01575

F

Seeded From UniProt

complete

involved_in

GO:0032728

positive regulation of interferon-beta production

PMID:24598055[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:24598055[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:3605069
PANTHER:PTN000466212

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000466212
RGD:620138

C

Seeded From UniProt

complete

enables

GO:0004896

cytokine receptor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000466212
ZFIN:ZDB-GENE-070905-4

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060337

type I interferon signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17181

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051607

defense response to virus

PMID:17277142[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050730

regulation of peptidyl-tyrosine phosphorylation

PMID:21606371[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050718

positive regulation of interleukin-1 beta secretion

PMID:23997220[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045351

type I interferon biosynthetic process

PMID:15800576[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042110

T cell activation

PMID:17164250[10]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96242

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032729

positive regulation of interferon-gamma production

PMID:17164250[10]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96242

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1305399

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17181

C

Seeded From UniProt

complete

enables

GO:0004905

type I interferon receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17181

F

Seeded From UniProt

complete

enables

GO:0004904

interferon receptor activity

PMID:16139798[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1930950

F

Seeded From UniProt

complete

enables

GO:0004904

interferon receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016669

F

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016669

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-MMU-912695

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0458
UniProtKB-SubCell:SL-0158

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0152

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Xu, J et al. (2014) TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways. J. Leukoc. Biol. 96 93-103 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Ren, Y et al. (2016) The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene. J. Biol. Chem. 291 13206-15 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Kumar, KG et al. (2003) SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J. 22 5480-90 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 de Weerd, NA et al. (2013) Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1. Nat. Immunol. 14 901-7 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Hervas-Stubbs, S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J. Immunol. 178 2361-9 PubMed GONUTS page
  7. ↑ Bhattacharyya, S et al. (2011) Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc. Natl. Acad. Sci. U.S.A. 108 9554-9 PubMed GONUTS page
  8. ↑ Shah, S et al. (2013) Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system. J. Immunol. 191 3514-8 PubMed GONUTS page
  9. ↑ Honda, K et al. (2005) IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434 772-7 PubMed GONUTS page
  10. ↑ 10.0 10.1 Osterloh, A et al. (2007) Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide. J. Biol. Chem. 282 4669-80 PubMed GONUTS page
  11. ↑ Giannakopoulos, NV et al. (2005) Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem. Biophys. Res. Commun. 336 496-506 PubMed GONUTS page
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