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MOUSE:IL27B
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Ebi3 (synonyms: Il27b) | |
| Protein Name(s) | Interleukin-27 subunit beta
IL-27 subunit beta IL-27B Epstein-Barr virus-induced gene 3 protein homolog | |
| External Links | ||
| UniProt | O35228 | |
| EMBL | AF013114 BC008209 | |
| CCDS | CCDS28888.1 | |
| RefSeq | NP_056581.1 | |
| UniGene | Mm.256798 | |
| ProteinModelPortal | O35228 | |
| SMR | O35228 | |
| DIP | DIP-60364N | |
| IntAct | O35228 | |
| STRING | 10090.ENSMUSP00000003274 | |
| PRIDE | O35228 | |
| Ensembl | ENSMUST00000003274 | |
| GeneID | 50498 | |
| KEGG | mmu:50498 | |
| UCSC | uc008daj.1 | |
| CTD | 10148 | |
| MGI | MGI:1354171 | |
| eggNOG | NOG43082 | |
| HOGENOM | HOG000294168 | |
| HOVERGEN | HBG052107 | |
| InParanoid | O35228 | |
| OMA | PTSFIAT | |
| OrthoDB | EOG789CCW | |
| PhylomeDB | O35228 | |
| TreeFam | TF331210 | |
| NextBio | 307494 | |
| PRO | PR:O35228 | |
| Proteomes | UP000000589 | |
| Bgee | O35228 | |
| CleanEx | MM_EBI3 MM_IL17B | |
| ExpressionAtlas | O35228 | |
| Genevestigator | O35228 | |
| GO | GO:0005615 GO:0016020 GO:0004896 GO:0045523 | |
| Gene3D | 2.60.40.10 | |
| InterPro | IPR003961 IPR003530 IPR013783 IPR015373 | |
| Pfam | PF09294 | |
| SMART | SM00060 | |
| SUPFAM | SSF49265 | |
| PROSITE | PS50853 PS01354 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0042098 |
T cell proliferation |
ECO:0000314 |
P |
Figure 4b and 4c in which T cells were cultured, showed this protein in mice to cause proliferative responses. |
complete | |||||
|
involved_in |
GO:0042098 |
T cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097059 |
CNTFR-CLCF1 complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001495218 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070110 |
ciliary neurotrophic factor receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001495218 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0045523 |
interleukin-27 receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1354171 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002745476 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019955 |
cytokine binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104579 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104579 |
C |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0004897 |
ciliary neurotrophic factor receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:99605 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004896 |
cytokine receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002745476 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0045523 |
interleukin-27 receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004896 |
cytokine receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004896 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004896 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004896 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004896 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070120 |
ciliary neurotrophic factor-mediated signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004897 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004896 |
cytokine receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14213 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004896 |
cytokine receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Pflanz, S et al. (2002) IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity 16 779-90 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
- Chordata
- GO:0070110 ! ciliary neurotrophic factor receptor complex
- GO:0070120 ! ciliary neurotrophic factor-mediated signaling pathway
- GO:0004897 ! ciliary neurotrophic factor receptor activity
- GO:0097059 ! CNTFR-CLCF1 complex
- Craniata
- GO:0019221 ! cytokine-mediated signaling pathway
- GO:0005125 ! cytokine activity
- GO:0019955 ! cytokine binding
- GO:0004896 ! cytokine receptor activity
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