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MOUSE:IF122
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Ift122 (synonyms: Wdr10) | |
| Protein Name(s) | Intraflagellar transport protein 122 homolog
WD repeat-containing protein 10 | |
| External Links | ||
| UniProt | Q6NWV3 | |
| EMBL | AK131115 AK031308 AK044456 AK167330 AK167412 BC066083 BC067415 | |
| CCDS | CCDS20445.1 CCDS51880.1 | |
| RefSeq | NP_001161235.1 NP_112454.2 | |
| UniGene | Mm.333335 | |
| ProteinModelPortal | Q6NWV3 | |
| SMR | Q6NWV3 | |
| BioGrid | 219896 | |
| IntAct | Q6NWV3 | |
| PhosphoSite | Q6NWV3 | |
| MaxQB | Q6NWV3 | |
| PaxDb | Q6NWV3 | |
| PRIDE | Q6NWV3 | |
| Ensembl | ENSMUST00000038234 ENSMUST00000112925 | |
| GeneID | 81896 | |
| KEGG | mmu:81896 | |
| UCSC | uc009djg.2 uc009dji.2 | |
| CTD | 55764 | |
| MGI | MGI:1932386 | |
| eggNOG | COG2319 | |
| GeneTree | ENSGT00390000001016 | |
| HOGENOM | HOG000261131 | |
| HOVERGEN | HBG069969 | |
| InParanoid | Q6NWV3 | |
| OrthoDB | EOG7P2XR8 | |
| TreeFam | TF105855 | |
| Reactome | REACT_269412 | |
| NextBio | 350457 | |
| PRO | PR:Q6NWV3 | |
| Proteomes | UP000000589 | |
| Bgee | Q6NWV3 | |
| ExpressionAtlas | Q6NWV3 | |
| Genevestigator | Q6NWV3 | |
| GO | GO:0036064 GO:0005737 GO:0030991 GO:0016020 GO:0032391 GO:0072372 GO:0048593 GO:0060830 GO:0060271 GO:0009953 GO:0010172 GO:0042733 GO:0035115 GO:0035050 GO:0060971 GO:0072594 GO:0035720 GO:0035721 GO:0060173 GO:0050680 GO:0045879 GO:0021914 GO:0001843 GO:0061512 GO:0007227 GO:0060831 | |
| Gene3D | 1.25.40.10 2.130.10.10 | |
| InterPro | IPR011990 IPR015943 IPR001680 IPR017986 | |
| Pfam | PF00400 | |
| SMART | SM00320 | |
| SUPFAM | SSF50978 | |
| PROSITE | PS50082 PS50294 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0097546 |
ciliary base |
ECO:0000314 |
C |
GFP tagged IFT122 shows ciliary basal localisation fig S4D |
complete | |||||
| GO:0035735 |
intraflagellar transport involved in cilium morphogenesis |
ECO:0000315 |
P |
Fig 3A shows swelling and widening of proximal cilia in IFT122 mutant. Stagnation of components of IFT complex B in IFT122 mutant show role in retrograde IFT mechanisms. NB sopb morphant proven to be IFT122 mutant by positional mapping and identification of sequence mutation. |
complete | |||||
| GO:0060971 |
embryonic heart tube left/right pattern formation |
ECO:0000315 |
P |
Fig S6A shows abnormally lateralised heart tubes in 12/25 mutant embryos NB sopb morphant proven to be IFT122 mutant by positional mapping and identification of sequence mutation. |
complete | |||||
| GO:0070986 |
left/right axis specification |
ECO:0000315 |
P |
Fig S6A shows abnormally bilateralised lateral plate mesoderm in 11/12 mutant embryos, opposed to 0 in WT NB sopb morphant proven to be IFT122 mutant by positional mapping and identification of sequence mutation. |
complete | |||||
| GO:0035721 |
intraflagellar retrograde transport |
ECO:0000315 |
P |
Fig 3A shows anterograde (ie IFT88 and IFT57) complex stagnates at tip of cilia with no retrograde clearance in IFT122 morphant. NB sopb morphant proven to be IFT122 mutant by positional mapping and identification of sequence mutation. |
complete | |||||
| GO:0061512 |
protein localization to cilium |
ECO:0000315 |
P |
Fig 3C and D shows localisation of IFT88 and IFT57 is arrested at axenomal tip in IFT122 mutant, ie localisation to ciliary body lost in morphant. NB sopb morphant proven to be IFT122 mutant by positional mapping and identification of sequence mutation. |
complete | |||||
| GO:0021914 |
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning |
ECO:0000315 |
P |
Multiple and cumulative evidence: 1. Gli2 dependent regulator of ventralising RNA expression (known to be via Smoothened signalling pathway) Fig 2B 2.Fig S7B shows Smo independent, Kif3a dependent ventralising RNA expression pattern change of dorsal/ventral neural tube with abnromal morphogenesis. 3. Regulates Gli2/3 localisation and protein cleavage. To increase negative repressor isotope, ie negative regulator of ventralisation. Fig S9E. NB sopb morphant proven to be IFT122 mutant by positional mapping and identification of sequence mutation. |
complete | |||||
| GO:0070613 |
regulation of protein processing |
ECO:0000315 |
P |
Regulates Gli3FL/Rep ratios, known to be produced by protein cleavage. This increase negative repressor isotope, ie negative regulator of ventralisation. Fig S9E. NB sopb morphant proven to be IFT122 mutant by positional mapping and identification of sequence mutation. |
complete | |||||
| GO:0007227 |
signal transduction downstream of smoothened |
ECO:0000315 |
P |
Fig 9A column 3 shows addition of SAG ie Smo antagonist, does not affect GLi2 or 3 intensity in cilia between WT and mutant. ie IFT122 is independent of Smo and therefore downstream. NB sopb morphant proven to be IFT122 mutant by positional mapping and identification of sequence mutation. |
complete | |||||
| GO:0035720 |
intraflagellar anterograde transport |
ECO:0000315 |
P |
loss of Tulp3 transport to the tip of the cilia in IFT122 mutant suggests a anterograde mechanism for IFT122 as well as retrograde. Fig 4A column A NB sopb morphant proven to be IFT122 mutant by positional mapping and identification of sequence mutation. |
complete | |||||
| GO:0035117 |
embryonic arm morphogenesis |
ECO:0000315 |
P |
Fig S3. shows a shortening of the forearm in the proximal - distal axis in the IFT 122 morphant |
complete | |||||
|
involved_in |
GO:0061512 |
protein localization to cilium |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042073 |
intraciliary transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061512 |
protein localization to cilium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060971 |
embryonic heart tube left/right pattern formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097546 |
ciliary base |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072594 |
establishment of protein localization to organelle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:Q61371)|has_input:(UniProtKB:Q8BXG3)|has_input:(UniProtKB:E9PY46)|has_input:(UniProtKB:Q0VGT2)|has_input:(UniProtKB:Q61602) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060971 |
embryonic heart tube left/right pattern formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0036064 |
ciliary basal body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035720 |
intraciliary anterograde transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:O88413) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035115 |
embryonic forelimb morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0021914 |
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007227 |
signal transduction downstream of smoothened |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005929 |
cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060173 |
limb development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048593 |
camera-type eye morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045879 |
negative regulation of smoothened signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035721 |
intraciliary retrograde transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035050 |
embryonic heart tube development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032391 |
photoreceptor connecting cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030991 |
intraciliary transport particle A |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010172 |
embryonic body morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001843 |
neural tube closure |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061512 |
protein localization to cilium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1932386 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035721 |
intraciliary retrograde transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0265102 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030991 |
intraciliary transport particle A |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1932386 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005929 |
cilium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1932386 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1905515 |
non-motile cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000312) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0061512 |
protein localization to cilium |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060831 |
smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2443231 |
P |
occurs_in:(EMAPA:16530) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060830 |
ciliary receptor clustering involved in smoothened signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2443231 |
P |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060271 |
cilium assembly |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2443231 |
P |
occurs_in:(EMAPA:16164) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060271 |
cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3578529 |
P |
occurs_in:(EMAPA:16164) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0050680 |
negative regulation of epithelial cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042733 |
embryonic digit morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3578529 |
P |
has_participant:(EMAPA:16405) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0030991 |
intraciliary transport particle A |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030991 |
intraciliary transport particle A |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0009953 |
dorsal/ventral pattern formation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98297 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0009953 |
dorsal/ventral pattern formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3578529 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
Missing: with/from | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061512 |
protein localization to cilium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9HBG6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9HBG6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042073 |
intraciliary transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9HBG6 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0036064 |
ciliary basal body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9HBG6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030991 |
intraciliary transport particle A |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9HBG6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005929 |
cilium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9HBG6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9HBG6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9HBG6 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005929 |
cilium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030030 |
cell projection organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Cortellino, S et al. (2009) Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4. Dev. Biol. 325 225-37 PubMed GONUTS page
- ↑ Jiang, ST et al. (2009) Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse. Hum. Mol. Genet. 18 1566-77 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 Ezratty, EJ et al. (2011) A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell 145 1129-41 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Liem, KF Jr et al. (2012) The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J. Cell Biol. 197 789-800 PubMed GONUTS page
- ↑ 7.0 7.1 García-García, MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U.S.A. 102 5913-9 PubMed GONUTS page
- ↑ Mukhopadhyay, S et al. (2010) TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev. 24 2180-93 PubMed GONUTS page
- ↑ Ocbina, PJ et al. (2011) Complex interactions between genes controlling trafficking in primary cilia. Nat. Genet. 43 547-53 PubMed GONUTS page
- ↑ Gross, C et al. (2001) Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis. DNA Cell Biol. 20 41-52 PubMed GONUTS page
c
- GO:0048593 ! camera-type eye morphogenesis
- GO:0030030 ! cell projection organization
- GO:0042995 ! cell projection
- Chordata
- GO:0036064 ! ciliary basal body
- GO:0097546 ! ciliary base
- GO:0060830 ! ciliary receptor clustering involved in smoothened signaling pathway
- GO:0005929 ! cilium
- GO:0060271 ! cilium assembly
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
e
- GO:0035117 ! embryonic arm morphogenesis
- GO:0010172 ! embryonic body morphogenesis
- GO:0042733 ! embryonic digit morphogenesis
- GO:0035115 ! embryonic forelimb morphogenesis
- GO:0035050 ! embryonic heart tube development
- GO:0060971 ! embryonic heart tube left/right pattern formation
- GO:0072594 ! establishment of protein localization to organelle
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
g
i
m
n
- GO:0045879 ! negative regulation of smoothened signaling pathway
- GO:0050680 ! negative regulation of epithelial cell proliferation
- GO:0021914 ! negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
- GO:0001843 ! neural tube closure
- GO:1905515 ! non-motile cilium assembly
- GO:0005654 ! nucleoplasm
s
