MOUSE:HXK2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hk2
Protein Name(s)	Hexokinase-2 Hexokinase type II HK II
External Links
UniProt	O08528
EMBL	Y11666 Y11667 Y11668 AJ238540 BC054472
CCDS	CCDS20263.1
RefSeq	NP_038848.1
UniGene	Mm.255848 Mm.469167
ProteinModelPortal	O08528
SMR	O08528
BioGrid	200316
DIP	DIP-41484N
IntAct	O08528
MINT	MINT-262872
STRING	10090.ENSMUSP00000000642
PhosphoSite	O08528
MaxQB	O08528
PaxDb	O08528
PRIDE	O08528
Ensembl	ENSMUST00000000642
GeneID	15277
KEGG	mmu:15277
UCSC	uc009cll.2
CTD	3099
MGI	MGI:1315197
eggNOG	COG5026
GeneTree	ENSGT00390000017159
HOGENOM	HOG000162671
HOVERGEN	HBG005020
InParanoid	O08528
KO	K00844
OMA	HHLGLES
OrthoDB	EOG7S21X5
PhylomeDB	O08528
TreeFam	TF314238
Reactome	REACT_253543
SABIO-RK	O08528
UniPathway	UPA00242
ChiTaRS	Hk2
NextBio	287909
PRO	PR:O08528
Proteomes	UP000000589
Bgee	O08528
CleanEx	MM_HK2
ExpressionAtlas	O08528
Genevestigator	O08528
GO	GO:0005829 GO:0005741 GO:0005739 GO:0005524 GO:0008865 GO:0004340 GO:0005536 GO:0004396 GO:0019158 GO:0008637 GO:0046835 GO:0001678 GO:0051156 GO:0006006 GO:0006096 GO:0007595 GO:0046324 GO:0002931
InterPro	IPR001312 IPR022673 IPR019807 IPR022672
PANTHER	PTHR19443
Pfam	PF00349 PF03727
PRINTS	PR00475
PROSITE	PS00378

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000378	negative regulation of reactive oxygen species metabolic process	PMID:22517678^[1]	ECO:0000315			P		Figure 4	complete CACAO 6674
	GO:0035795	negative regulation of mitochondrial membrane permeability	PMID:22517678^[1]	ECO:0000315			P		Fig 7	complete CACAO 6675
involved_in	GO:0035795	negative regulation of mitochondrial membrane permeability	PMID:22517678^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	PMID:22517678^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019158	mannokinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c	F		Seeded From UniProt	complete
enables	GO:0008865	fructokinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c TAIR:locus:2008031 TAIR:locus:2087590 TAIR:locus:2119931 TAIR:locus:2137564 TAIR:locus:2202410 UniProtKB:P93834 UniProtKB:Q4WHC3	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 RGD:2670 RGD:2796 SGD:S000000545 SGD:S000001949 SGD:S000003222	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 MGI:MGI:96103 PANTHER:PTN000455350 RGD:2670 RGD:2796 SGD:S000003222 UniProtKB:C6KT76 UniProtKB:P35557	C		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 MGI:MGI:96103 PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c RGD:2670 RGD:2796 SGD:S000000545 TAIR:locus:2008031 TAIR:locus:2087590 TAIR:locus:2119931 TAIR:locus:2137564 TAIR:locus:2202410 UniProtKB:P35557 UniProtKB:P93834 UniProtKB:Q4WCS2 UniProtKB:Q4WHC3 UniProtKB:Q5W676 UniProtKB:Q8LQ68	F		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 PANTHER:PTN000455350 RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990830	cellular response to leukemia inhibitory factor	PMID:20439489^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P52789	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072656	maintenance of protein location in mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P52789	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072655	establishment of protein localization to mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P52789	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046835	carbohydrate phosphorylation	PMID:10428828^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3624862	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046835	carbohydrate phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046324	regulation of glucose import	PMID:17639019^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3624862	P	regulates_o_occurs_in:(EMAPA:32716)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P52789	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2797	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008637	apoptotic mitochondrial changes	PMID:18350175^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1353495 MGI:MGI:2145814	P	occurs_in:(CL:0000057)\|occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008637	apoptotic mitochondrial changes	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P52789	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	PMID:10428828^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3624862	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2797	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2797	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P52789	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2797	C		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2797	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2797	F		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	PMID:10428828^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3624862	F		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	PMID:18165236^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2797	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002931	response to ischemia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2797	P		Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004340	P		Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	C		Seeded From UniProt	complete
involved_in	GO:0007595	lactation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	C		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	F		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	F		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27881 ensembl:ENSRNOP00000008813	P		Seeded From UniProt	complete
involved_in	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52789 ensembl:ENSP00000290573	P		Seeded From UniProt	complete
involved_in	GO:0072656	maintenance of protein location in mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52789 ensembl:ENSP00000290573	P		Seeded From UniProt	complete
involved_in	GO:0072655	establishment of protein localization to mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52789 ensembl:ENSP00000290573	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52789 ensembl:ENSP00000290573	P		Seeded From UniProt	complete
involved_in	GO:0008637	apoptotic mitochondrial changes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52789 ensembl:ENSP00000290573	P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52789 ensembl:ENSP00000290573	C		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312	P		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807 InterPro:IPR022672 InterPro:IPR022673	F		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312	F		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR022672 InterPro:IPR022673	P		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019807	P		Seeded From UniProt	complete
enables	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022672 InterPro:IPR022673	F		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.1	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0019318	hexose metabolic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00242	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Wu, R et al. (2012) Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production. EMBO Mol Med 4 633-46 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Heikkinen, S et al. (1999) Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes. J. Biol. Chem. 274 22517-23 PubMed GONUTS page
↑ Fueger, PT et al. (2007) Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II. Diabetes 56 2476-84 PubMed GONUTS page
↑ Chiara, F et al. (2008) Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS ONE 3 e1852 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Cifuentes, D et al. (2008) Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver. J. Biol. Chem. 283 5642-9 PubMed GONUTS page

[PMID:22517678-1] 1.0 ^1.1 ^1.2 ^1.3 Wu, R et al. (2012) Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production. EMBO Mol Med 4 633-46 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20439489-3] Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page

[PMID:10428828-4] 4.0 ^4.1 ^4.2 Heikkinen, S et al. (1999) Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes. J. Biol. Chem. 274 22517-23 PubMed GONUTS page

[PMID:17639019-5] Fueger, PT et al. (2007) Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II. Diabetes 56 2476-84 PubMed GONUTS page

[PMID:18350175-6] Chiara, F et al. (2008) Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS ONE 3 e1852 PubMed GONUTS page

[PMID:18614015-7] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:18165236-8] Cifuentes, D et al. (2008) Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver. J. Biol. Chem. 283 5642-9 PubMed GONUTS page

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MOUSE:HXK2

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