MOUSE:HOME1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Homer1 (synonyms: Vesl1)
Protein Name(s)	Homer protein homolog 1 Homer-1 VASP/Ena-related gene up-regulated during seizure and LTP 1 Vesl-1
External Links
UniProt	Q9Z2Y3
EMBL	AF093257 AF093258 AY137385 AB019478 AB019479 AB089435
CCDS	CCDS26687.1 CCDS36745.1 CCDS36746.1 CCDS70484.1
RefSeq	NP_001271118.1 NP_036112.1 NP_671705.2 NP_687036.1
UniGene	Mm.37533
ProteinModelPortal	Q9Z2Y3
SMR	Q9Z2Y3
BioGrid	205014
IntAct	Q9Z2Y3
MINT	MINT-3370083
TCDB	8.A.29.1.1
PhosphoSite	Q9Z2Y3
MaxQB	Q9Z2Y3
PaxDb	Q9Z2Y3
PRIDE	Q9Z2Y3
Ensembl	ENSMUST00000060490 ENSMUST00000079086 ENSMUST00000080127 ENSMUST00000102752 ENSMUST00000109492
GeneID	26556
KEGG	mmu:26556
UCSC	uc007rlc.2 uc007rld.2 uc007rle.2
CTD	9456
MGI	MGI:1347345
eggNOG	NOG68331
GeneTree	ENSGT00390000017850
HOGENOM	HOG000006979
HOVERGEN	HBG051918
InParanoid	Q9Z2Y3
KO	K15010
OMA	QNSEPRP
PhylomeDB	Q9Z2Y3
TreeFam	TF325627
NextBio	304603
PRO	PR:Q9Z2Y3
Proteomes	UP000000589
Bgee	Q9Z2Y3
CleanEx	MM_HOMER1
ExpressionAtlas	Q9Z2Y3
Genevestigator	Q9Z2Y3
GO	GO:0045177 GO:0030424 GO:0030054 GO:0043034 GO:0005737 GO:0043198 GO:0060076 GO:0016020 GO:0043005 GO:0043025 GO:0097481 GO:0005886 GO:0045211 GO:0030018 GO:0048148 GO:0048875 GO:0007623 GO:0007216 GO:0051928 GO:0035418 GO:0090279 GO:2001257 GO:2001256 GO:0051592 GO:0035094 GO:0003009 GO:0048741
Gene3D	2.30.29.30
InterPro	IPR011993 IPR000697
Pfam	PF00568
SMART	SM00461
PROSITE	PS50229

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0014069	postsynaptic density	PMID:21664258^[1]	ECO:0000315			C		Figure 2A- from Synaptosomal fraction found in postsynaptic density fraction of wild type and adult heterozygous reeler mice	complete CACAO 2357
	GO:0043005	neuron projection	PMID:21664258^[1]	ECO:0000315			C		Figure 2A- from Synaptosomal fraction found in postsynaptic density fraction of wild type and adult heterozygous reeler mice.	complete CACAO 2358
	GO:0014069	postsynaptic density	PMID:21558424^[2]	ECO:0000315			C		Figure 6A and C, A decrease of PSD proteins in postsynaptic density fraction. There was a decrease in homer 1 protein in mutant Shank3 mice. Similar results was seen in figure 6E, confirmed by quantitative analyses.	complete CACAO 3129
part_of	GO:0044309	neuron spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z214-2	C		Seeded From UniProt	complete
involved_in	GO:1902950	regulation of dendritic spine maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z214-2	P		Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z214-2	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21144999^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0005377)\|part_of:(UBERON:0004167)\|part_of:(UBERON:0007631)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21664258^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21558424^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21664258^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z214-2	P		Seeded From UniProt	complete
involved_in	GO:2001257	regulation of cation channel activity	PMID:14505576^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001256	regulation of store-operated calcium entry	PMID:14505576^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21558424^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21664258^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090279	regulation of calcium ion import	PMID:14505576^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21795692^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	PMID:24530450^[6]	ECO:0006042	cell fractionation evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	PMID:24530450^[6]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:11418862^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:11418862^[7]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0098962	regulation of postsynaptic neurotransmitter receptor activity	PMID:11418862^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0098962	regulation of postsynaptic neurotransmitter receptor activity	PMID:11418862^[7]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:2001256	regulation of store-operated calcium entry	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347345 PANTHER:PTN000857479	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347345 PANTHER:PTN000099620 RGD:628725	C		Seeded From UniProt	complete
enables	GO:0035256	G protein-coupled glutamate receptor binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000857479 RGD:620705 RGD:628725	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000099620 RGD:620705 RGD:628725	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347345 MGI:MGI:1347359 PANTHER:PTN000099620 RGD:628725	C		Seeded From UniProt	complete
involved_in	GO:0007216	G protein-coupled glutamate receptor signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000857479 RGD:628725	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347345 PANTHER:PTN000857479	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347345 MGI:MGI:1347354 PANTHER:PTN000857479 UniProtKB:Q9NSB8	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902950	regulation of dendritic spine maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	P		Seeded From UniProt	complete
enables	GO:0099186	structural constituent of postsynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	F		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:24554721^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	F		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	F		Seeded From UniProt	complete
colocalizes_with	GO:0060076	excitatory synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051966	regulation of synaptic transmission, glutamatergic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051928	positive regulation of calcium ion transport	PMID:18268005^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3526529	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051592	response to calcium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86YM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051262	protein tetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048875	chemical homeostasis within a tissue	PMID:15294147^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3526529	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048741	skeletal muscle fiber development	PMID:18268005^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3526529	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048148	behavioral response to cocaine	PMID:15294147^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3526529	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:12860966^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35651) part_of:(CL:0002064)	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86YM7	F		Seeded From UniProt	complete
part_of	GO:0044309	neuron spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	C		Seeded From UniProt	complete
part_of	GO:0043034	costamere	PMID:18268005^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035418	protein localization to synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	P		Seeded From UniProt	complete
enables	GO:0035256	G protein-coupled glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	F		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:23791195^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:18268005^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35578)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15579147^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:24613359^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:23791195^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007216	G protein-coupled glutamate receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12176012^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12176012^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628725	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003009	skeletal muscle contraction	PMID:18268005^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3526529	P		Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099186	P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86YM7 ensembl:ENSP00000334382	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86YM7 ensembl:ENSP00000334382	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007216	G protein-coupled glutamate receptor signaling pathway	PMID:9808458^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Ventruti, A et al. (2011) Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience 189 32-42 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Wang, X et al. (2011) Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum. Mol. Genet. 20 3093-108 PubMed GONUTS page
↑ Dani, A et al. (2010) Superresolution imaging of chemical synapses in the brain. Neuron 68 843-56 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Yuan, JP et al. (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114 777-89 PubMed GONUTS page
↑ Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page
↑ ^6.0 ^6.1 Tao-Cheng, JH et al. (2014) Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation. Neuroscience 266 80-90 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Ango, F et al. (2001) Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 411 962-5 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Herrera-Molina, R et al. (2014) Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65. J. Biol. Chem. 289 8973-88 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Stiber, JA et al. (2008) Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. Mol. Cell. Biol. 28 2637-47 PubMed GONUTS page
↑ ^11.0 ^11.1 Szumlinski, KK et al. (2004) Homer proteins regulate sensitivity to cocaine. Neuron 43 401-13 PubMed GONUTS page
↑ Shin, DM et al. (2003) Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. J. Cell Biol. 162 293-303 PubMed GONUTS page
↑ ^13.0 ^13.1 Wentzel, C et al. (2013) mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. Neuron 78 1012-23 PubMed GONUTS page
↑ Nakamura, M et al. (2004) Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur. J. Neurosci. 20 2929-44 PubMed GONUTS page
↑ Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page
↑ ^16.0 ^16.1 Saito, H et al. (2002) An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cells. Biochem. Biophys. Res. Commun. 296 523-9 PubMed GONUTS page
↑ Xiao, B et al. (1998) Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21 707-16 PubMed GONUTS page

[PMID:21664258-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Ventruti, A et al. (2011) Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience 189 32-42 PubMed GONUTS page

[PMID:21558424-2] 2.0 ^2.1 ^2.2 Wang, X et al. (2011) Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum. Mol. Genet. 20 3093-108 PubMed GONUTS page

[PMID:21144999-3] Dani, A et al. (2010) Superresolution imaging of chemical synapses in the brain. Neuron 68 843-56 PubMed GONUTS page

[PMID:14505576-4] 4.0 ^4.1 ^4.2 Yuan, JP et al. (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114 777-89 PubMed GONUTS page

[PMID:21795692-5] Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page

[PMID:24530450-6] 6.0 ^6.1 Tao-Cheng, JH et al. (2014) Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation. Neuroscience 266 80-90 PubMed GONUTS page

[PMID:11418862-7] 7.0 ^7.1 ^7.2 ^7.3 Ango, F et al. (2001) Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 411 962-5 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24554721-9] Herrera-Molina, R et al. (2014) Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65. J. Biol. Chem. 289 8973-88 PubMed GONUTS page

[PMID:18268005-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Stiber, JA et al. (2008) Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. Mol. Cell. Biol. 28 2637-47 PubMed GONUTS page

[PMID:15294147-11] 11.0 ^11.1 Szumlinski, KK et al. (2004) Homer proteins regulate sensitivity to cocaine. Neuron 43 401-13 PubMed GONUTS page

[PMID:12860966-12] Shin, DM et al. (2003) Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. J. Cell Biol. 162 293-303 PubMed GONUTS page

[PMID:23791195-13] 13.0 ^13.1 Wentzel, C et al. (2013) mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. Neuron 78 1012-23 PubMed GONUTS page

[PMID:15579147-14] Nakamura, M et al. (2004) Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur. J. Neurosci. 20 2929-44 PubMed GONUTS page

[PMID:24613359-15] Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page

[PMID:12176012-16] 16.0 ^16.1 Saito, H et al. (2002) An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cells. Biochem. Biophys. Res. Commun. 296 523-9 PubMed GONUTS page

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