MOUSE:HFE

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hfe (synonyms: Mr2)
Protein Name(s)	Hereditary hemochromatosis protein homolog
External Links
UniProt	P70387
EMBL	AF007558 U66849 AK009581 AK150697 AL590388 CH466561 BC116744 BC116746 Y12650 U80604
CCDS	CCDS26360.1
PIR	JC5382
RefSeq	NP_034554.2
UniGene	Mm.2681
ProteinModelPortal	P70387
SMR	P70387
STRING	10090.ENSMUSP00000089298
PhosphoSite	P70387
PaxDb	P70387
PRIDE	P70387
Ensembl	ENSMUST00000091706
GeneID	15216
KEGG	mmu:15216
UCSC	uc007pup.1
CTD	3077
MGI	MGI:109191
eggNOG	NOG41118
GeneTree	ENSGT00760000118960
HOGENOM	HOG000296917
HOVERGEN	HBG016709
InParanoid	P70387
OMA	NHSKVTK
TreeFam	TF336617
NextBio	287795
PRO	PR:P70387
Proteomes	UP000000589
Bgee	P70387
CleanEx	MM_HFE
ExpressionAtlas	P70387
Genevestigator	P70387
GO	GO:0045177 GO:0045178 GO:0031410 GO:0005769 GO:0016021 GO:0042612 GO:0048471 GO:0055037 GO:0042605 GO:0002474 GO:0010106 GO:0007565 GO:0042446 GO:0006955 GO:0055072 GO:0097459 GO:0060586 GO:0001916
Gene3D	2.60.40.10 3.30.500.10
InterPro	IPR007110 IPR013783 IPR003006 IPR003597 IPR011161 IPR011162 IPR027648 IPR001039
Pfam	PF07654 PF00129
PRINTS	PR01638
SMART	SM00407
SUPFAM	SSF54452
PROSITE	PS50835 PS00290

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006955	immune response	PMID:19809161^[1]	ECO:0000314			P		Figure 1. Peritoneal macrophages from WT and Hfe KO mice were stimulated with LPS. Supernatants were collected and analyzed by ELISA for TNF-α. Observations on TNF-α expression support the notion that the abnormal TLR4-activated cytokine response of the Hfe KO macrophages is caused by the low intracellular iron in these cells rather than being a cell-autonomous consequence of Hfe deficiency.	complete
enables	GO:1990459	transferrin receptor binding	PMID:16893896^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9JKX3	F		Seeded From UniProt	complete
enables	GO:1990459	transferrin receptor binding	PMID:16893896^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62351	F		Seeded From UniProt	complete
part_of	GO:1990712	HFE-transferrin receptor complex	PMID:16893896^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	PMID:24904118^[3]	ECO:0000305	curator inference used in manual assertion	GO:0010628	P	has_regulation_target:(UniProtKB:P36895)	Seeded From UniProt	complete
involved_in	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:24904118^[3]	ECO:0000305	curator inference used in manual assertion	GO:0010628	P	has_regulation_target:(UniProtKB:P36895)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24904118^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P36895)	Seeded From UniProt	complete
involved_in	GO:1990641	response to iron ion starvation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000422361 RGD:2793	P		Seeded From UniProt	complete
enables	GO:1990459	transferrin receptor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109191 PANTHER:PTN000422361 UniProtKB:Q30201	F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107674 MGI:MGI:109431 MGI:MGI:109432 MGI:MGI:1861032 MGI:MGI:1925027 MGI:MGI:2179988 MGI:MGI:2179989 MGI:MGI:95896 MGI:MGI:95904 MGI:MGI:95915 MGI:MGI:95938 PANTHER:PTN002314307 UniProtKB:Q30201	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95896 PANTHER:PTN002314307 UniProtKB:Q95460 UniProtKB:Q9BZM6	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95929 PANTHER:PTN002314307 UniProtKB:P25311 UniProtKB:Q29983 UniProtKB:Q30201 UniProtKB:Q9BZM5	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001186	negative regulation of CD8-positive, alpha-beta T cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000273	positive regulation of signaling receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000272	negative regulation of signaling receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000008	regulation of protein localization to cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
part_of	GO:1990712	HFE-transferrin receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	C		Seeded From UniProt	complete
enables	GO:1990459	transferrin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	F		Seeded From UniProt	complete
part_of	GO:1990357	terminal web	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2793	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904437	positive regulation of transferrin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904434	positive regulation of ferrous iron binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904283	negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900122	positive regulation of receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900121	negative regulation of receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090277	positive regulation of peptide hormone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071281	cellular response to iron ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060586	multicellular organismal iron ion homeostasis	PMID:10077651^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181388	P	has_participant:(EMAPA:35770)\|has_participant:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055072	iron ion homeostasis	PMID:22960056^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3775648	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055072	iron ion homeostasis	PMID:21059897^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055072	iron ion homeostasis	PMID:15914561^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385353	P	has_participant:(EMAPA:16846)\|has_participant:(EMAPA:18767)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055072	iron ion homeostasis	PMID:15131800^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934013	P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055072	iron ion homeostasis	PMID:10077651^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181388	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055072	iron ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
part_of	GO:0045178	basal part of cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2793	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042446	hormone biosynthetic process	PMID:15914561^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385353	P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034756	regulation of iron ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	C		Seeded From UniProt	complete
enables	GO:0030881	beta-2-microglobulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010039	response to iron ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006879	cellular iron ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002725	negative regulation of T cell cytokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q30201	P		Seeded From UniProt	complete
involved_in	GO:1990641	response to iron ion starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35799 ensembl:ENSRNOP00000022881	P		Seeded From UniProt	complete
part_of	GO:1990357	terminal web	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35799 ensembl:ENSRNOP00000022881	C		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35799 ensembl:ENSRNOP00000022881	P		Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35799 ensembl:ENSRNOP00000022881	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35799 ensembl:ENSRNOP00000022881	C		Seeded From UniProt	complete
involved_in	GO:0010106	cellular response to iron ion starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35799 ensembl:ENSRNOP00000022881	P		Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35799 ensembl:ENSRNOP00000022881	P		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35799 ensembl:ENSRNOP00000022881	P		Seeded From UniProt	complete
involved_in	GO:2001186	negative regulation of CD8-positive, alpha-beta T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:2000273	positive regulation of signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:2000272	negative regulation of signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:2000008	regulation of protein localization to cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
part_of	GO:1990712	HFE-transferrin receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	C		Seeded From UniProt	complete
enables	GO:1990459	transferrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	F		Seeded From UniProt	complete
involved_in	GO:1904437	positive regulation of transferrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:1904434	positive regulation of ferrous iron binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:1904283	negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:1900122	positive regulation of receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:1900121	negative regulation of receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:0090277	positive regulation of peptide hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:0071281	cellular response to iron ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	C		Seeded From UniProt	complete
involved_in	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
part_of	GO:0045178	basal part of cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	C		Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	F		Seeded From UniProt	complete
involved_in	GO:0034756	regulation of iron ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	C		Seeded From UniProt	complete
enables	GO:0030881	beta-2-microglobulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	F		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	C		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	F		Seeded From UniProt	complete
involved_in	GO:0002725	negative regulation of T cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q30201 ensembl:ENSP00000417404	P		Seeded From UniProt	complete
involved_in	GO:0002626	negative regulation of T cell antigen processing and presentation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031092	P		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031092	P		Seeded From UniProt	complete
involved_in	GO:0098711	iron ion import across plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031092	P		Seeded From UniProt	complete
enables	GO:1990459	transferrin receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031092	F		Seeded From UniProt	complete
part_of	GO:1990712	HFE-transferrin receptor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031092	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0410	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wang, L et al. (2009) Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J. Clin. Invest. 119 3322-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Goswami, T & Andrews, NC (2006) Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J. Biol. Chem. 281 28494-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Wu, XG et al. (2014) HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood 124 1335-43 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Fleming, RE et al. (1999) Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc. Natl. Acad. Sci. U.S.A. 96 3143-8 PubMed GONUTS page
↑ Vujić Spasić, M et al. (2013) Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload. Biochim. Biophys. Acta 1832 76-84 PubMed GONUTS page
↑ Ramos, P et al. (2011) Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis. Blood 117 1379-89 PubMed GONUTS page
↑ ^8.0 ^8.1 Makui, H et al. (2005) Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading. Blood 106 2189-95 PubMed GONUTS page
↑ Bensaid, M et al. (2004) Multigenic control of hepatic iron loading in a murine model of hemochromatosis. Gastroenterology 126 1400-8 PubMed GONUTS page

[PMID:19809161-1] Wang, L et al. (2009) Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J. Clin. Invest. 119 3322-8 PubMed GONUTS page

[PMID:16893896-2] 2.0 ^2.1 ^2.2 Goswami, T & Andrews, NC (2006) Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J. Biol. Chem. 281 28494-8 PubMed GONUTS page

[PMID:24904118-3] 3.0 ^3.1 ^3.2 Wu, XG et al. (2014) HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood 124 1335-43 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10077651-5] 5.0 ^5.1 Fleming, RE et al. (1999) Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc. Natl. Acad. Sci. U.S.A. 96 3143-8 PubMed GONUTS page

[PMID:22960056-6] Vujić Spasić, M et al. (2013) Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload. Biochim. Biophys. Acta 1832 76-84 PubMed GONUTS page

[PMID:21059897-7] Ramos, P et al. (2011) Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis. Blood 117 1379-89 PubMed GONUTS page

[PMID:15914561-8] 8.0 ^8.1 Makui, H et al. (2005) Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading. Blood 106 2189-95 PubMed GONUTS page

[PMID:15131800-9] Bensaid, M et al. (2004) Multigenic control of hepatic iron loading in a murine model of hemochromatosis. Gastroenterology 126 1400-8 PubMed GONUTS page

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