MOUSE:GRID2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Grid2
Protein Name(s)	Glutamate receptor ionotropic, delta-2 GluD2 GluR delta-2 subunit
External Links
UniProt	Q61625
EMBL	D13266 BC139823
CCDS	CCDS20202.1
PIR	PN0156
RefSeq	NP_032193.1
UniGene	Mm.439651 Mm.447390
ProteinModelPortal	Q61625
SMR	Q61625
BioGrid	200062
IntAct	Q61625
MINT	MINT-126960
STRING	10090.ENSMUSP00000093536
BindingDB	Q61625
GuidetoPHARMACOLOGY	449
TCDB	1.A.10.1.8
PhosphoSite	Q61625
MaxQB	Q61625
PaxDb	Q61625
PRIDE	Q61625
Ensembl	ENSMUST00000095852
GeneID	14804
KEGG	mmu:14804
UCSC	uc009cdz.1
CTD	2895
MGI	MGI:95813
eggNOG	NOG276334
GeneTree	ENSGT00760000118920
HOGENOM	HOG000264260
HOVERGEN	HBG051840
InParanoid	Q61625
KO	K05207
OMA	NYGEDRG
OrthoDB	EOG7KQ20V
PhylomeDB	Q61625
TreeFam	TF352434
ChiTaRS	Grid2
NextBio	286973
PRO	PR:Q61625
Proteomes	UP000000589
Bgee	Q61625
CleanEx	MM_GRID2
ExpressionAtlas	Q61625
Genevestigator	Q61625
GO	GO:0030054 GO:0043197 GO:0008328 GO:0016020 GO:0005886 GO:0045211 GO:0045202 GO:0005234 GO:0004970 GO:0030165 GO:0097110 GO:0034613 GO:0021707 GO:0007157 GO:0034220 GO:0035235 GO:0060134 GO:0060079 GO:0043523 GO:0010975 GO:0035249
InterPro	IPR001828 IPR019594 IPR001508 IPR001320 IPR028082
Pfam	PF01094 PF00060
PRINTS	PR00177
SMART	SM00918 SM00079
SUPFAM	SSF53822

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005886	plasma membrane	PMID:\| ECO:0000314			C		Figure 1A, GluR delta 2 localized to plasma membrane.	Missing: reference
	GO:0043197	dendritic spine	PMID:15207857^[1]	ECO:0000314			C		Figure 3A, immunohistochemical analysis showed GluR delta 2 protein staining on dendritic spines of purkinje cells	complete
part_of	GO:0036477	somatodendritic compartment	PMID:18341993^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:15207857^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62108	F		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:15207857^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:15207857^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	PMID:15207857^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q80Z38)\|has_direct_input:(UniProtKB:D3YZU1)	Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:15207857^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q80Z38	F		Seeded From UniProt	complete
involved_in	GO:0021707	cerebellar granule cell differentiation	PMID:20537373^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9R171	P		Seeded From UniProt	complete
part_of	GO:0008328	ionotropic glutamate receptor complex	PMID:15207857^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:20537373^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9R171	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15207857^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0099151	regulation of postsynaptic density assembly	PMID:20395510^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099151	regulation of postsynaptic density assembly	PMID:20395510^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099151	regulation of postsynaptic density assembly	PMID:20395510^[4]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:20395510^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098688) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:20395510^[4]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(GO:0098688) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20395510^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20395510^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20395510^[4]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098688	parallel fiber to Purkinje cell synapse	PMID:20395510^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098688	parallel fiber to Purkinje cell synapse	PMID:20395510^[4]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95815 PANTHER:PTN001826301	F		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001826301 UniProtKB:Q13002	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0020429 MGI:MGI:95813 MGI:MGI:95815 MGI:MGI:95817 MGI:MGI:95818 PANTHER:PTN001826301 RGD:68366 RGD:68368	C		Seeded From UniProt	complete
involved_in	GO:0035249	synaptic transmission, glutamatergic	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0020429 FB:FBgn0039916 MGI:MGI:95813 MGI:MGI:95814 MGI:MGI:95815 MGI:MGI:95818 PANTHER:PTN001826301	P		Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 PANTHER:PTN001826301 RGD:2733 RGD:2735 RGD:71027	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0052704 MGI:MGI:95808 MGI:MGI:95813 MGI:MGI:95816 PANTHER:PTN000437926 RGD:621531 TAIR:locus:2207165 UniProtKB:Q12879 UniProtKB:Q13224 UniProtKB:Q16478 WB:WBGene00001612	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905606	regulation of presynapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68368	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904861	excitatory synapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43424	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900454	positive regulation of long-term synaptic depression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43424	P		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68368	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68368	C		Seeded From UniProt	complete
part_of	GO:0098688	parallel fiber to Purkinje cell synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68368	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060134	prepulse inhibition	PMID:11488959^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178052	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:7766857^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178052	P	occurs_in:(EMAPA:35223) regulates_o_occurs_in:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051965	positive regulation of synapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43424	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68368	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:18509461^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000121)	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:12372286^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043523	regulation of neuron apoptotic process	PMID:10884318^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P	regulates_o_occurs_in:(EMAPA:17787) regulates_o_occurs_in:(CL:0000120)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043523	regulation of neuron apoptotic process	PMID:10884318^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857337	P	regulates_o_occurs_in:(EMAPA:17787) regulates_o_occurs_in:(CL:0000121)\|regulates_o_occurs_in:(EMAPA:17787) regulates_o_occurs_in:(CL:0000120)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68368	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035249	synaptic transmission, glutamatergic	PMID:7766857^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178052	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68368	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15579147^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68368	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010975	regulation of neuron projection development	PMID:7891151^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857337	P	regulates_o_occurs_in:(EMAPA:35234) regulates_o_occurs_in:(CL:0000121)\|regulates_o_occurs_in:(EMAPA:19241)	Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005216	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004970	P		Seeded From UniProt	complete
involved_in	GO:1904861	excitatory synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43424 ensembl:ENSP00000282020	P		Seeded From UniProt	complete
involved_in	GO:1900454	positive regulation of long-term synaptic depression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43424 ensembl:ENSP00000282020	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43424 ensembl:ENSP00000282020	P		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR019594	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR001508 InterPro:IPR019594	C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Uemura, T et al. (2004) Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol. Cell. Neurosci. 26 330-41 PubMed GONUTS page
↑ Matsuda, S et al. (2008) Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Neuron 57 730-45 PubMed GONUTS page
↑ ^3.0 ^3.1 Uemura, T et al. (2010) Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum. Cell 141 1068-79 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Matsuda, K et al. (2010) Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer. Science 328 363-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Takeuchi, T et al. (2001) Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex. Eur. J. Neurosci. 14 153-60 PubMed GONUTS page
↑ ^7.0 ^7.1 Hirano, T et al. (1995) Suppression of LTD in cultured Purkinje cells deficient in the glutamate receptor delta 2 subunit. Neuroreport 6 524-6 PubMed GONUTS page
↑ Takeuchi, T et al. (2008) Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin. PLoS ONE 3 e2297 PubMed GONUTS page
↑ Yue, Z et al. (2002) A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron 35 921-33 PubMed GONUTS page
↑ ^10.0 ^10.1 Selimi, F et al. (2000) Bax inactivation in lurcher mutants rescues cerebellar granule cells but not purkinje cells or inferior olivary neurons. J. Neurosci. 20 5339-45 PubMed GONUTS page
↑ Nakamura, M et al. (2004) Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur. J. Neurosci. 20 2929-44 PubMed GONUTS page
↑ Rossi, F et al. (1995) Target neuron controls the integrity of afferent axon phenotype: a study on the Purkinje cell-climbing fiber system in cerebellar mutant mice. J. Neurosci. 15 2040-56 PubMed GONUTS page

[PMID:15207857-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Uemura, T et al. (2004) Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol. Cell. Neurosci. 26 330-41 PubMed GONUTS page

[PMID:18341993-2] Matsuda, S et al. (2008) Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Neuron 57 730-45 PubMed GONUTS page

[PMID:20537373-3] 3.0 ^3.1 Uemura, T et al. (2010) Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum. Cell 141 1068-79 PubMed GONUTS page

[PMID:20395510-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Matsuda, K et al. (2010) Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer. Science 328 363-8 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11488959-6] Takeuchi, T et al. (2001) Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex. Eur. J. Neurosci. 14 153-60 PubMed GONUTS page

[PMID:7766857-7] 7.0 ^7.1 Hirano, T et al. (1995) Suppression of LTD in cultured Purkinje cells deficient in the glutamate receptor delta 2 subunit. Neuroreport 6 524-6 PubMed GONUTS page

[PMID:18509461-8] Takeuchi, T et al. (2008) Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin. PLoS ONE 3 e2297 PubMed GONUTS page

[PMID:12372286-9] Yue, Z et al. (2002) A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron 35 921-33 PubMed GONUTS page

[PMID:10884318-10] 10.0 ^10.1 Selimi, F et al. (2000) Bax inactivation in lurcher mutants rescues cerebellar granule cells but not purkinje cells or inferior olivary neurons. J. Neurosci. 20 5339-45 PubMed GONUTS page

[PMID:15579147-11] Nakamura, M et al. (2004) Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur. J. Neurosci. 20 2929-44 PubMed GONUTS page

[PMID:7891151-12] Rossi, F et al. (1995) Target neuron controls the integrity of afferent axon phenotype: a study on the Purkinje cell-climbing fiber system in cerebellar mutant mice. J. Neurosci. 15 2040-56 PubMed GONUTS page

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MOUSE:GRID2

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References

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