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MOUSE:GPNMB
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Gpnmb (synonyms: Dchil, Hgfin, Nmb) | |
| Protein Name(s) | Transmembrane glycoprotein NMB
DC-HIL Dendritic cell-associated transmembrane protein Osteoactivin | |
| External Links | ||
| UniProt | Q99P91 | |
| EMBL | AF322054 AJ251685 AK044764 AK076347 AK150739 AK154617 AK170506 AK171441 AK171465 AK171474 AK171517 BC026375 | |
| CCDS | CCDS20122.1 | |
| RefSeq | NP_444340.3 | |
| UniGene | Mm.302602 | |
| ProteinModelPortal | Q99P91 | |
| SMR | Q99P91 | |
| IntAct | Q99P91 | |
| PhosphoSite | Q99P91 | |
| MaxQB | Q99P91 | |
| PRIDE | Q99P91 | |
| Ensembl | ENSMUST00000031840 | |
| GeneID | 93695 | |
| KEGG | mmu:93695 | |
| UCSC | uc012elo.1 | |
| CTD | 10457 | |
| MGI | MGI:1934765 | |
| eggNOG | NOG40272 | |
| GeneTree | ENSGT00530000063573 | |
| HOGENOM | HOG000252941 | |
| HOVERGEN | HBG051797 | |
| InParanoid | Q99P91 | |
| OMA | HTYVLNG | |
| OrthoDB | EOG7GXPB9 | |
| TreeFam | TF334865 | |
| ChiTaRS | Gpnmb | |
| NextBio | 351449 | |
| PRO | PR:Q99P91 | |
| Proteomes | UP000000589 | |
| Bgee | Q99P91 | |
| CleanEx | MM_GPNMB MM_NMB | |
| ExpressionAtlas | Q99P91 | |
| Genevestigator | Q99P91 | |
| GO | GO:0016023 GO:0030659 GO:0012505 GO:0005887 GO:0042470 GO:0008201 GO:0005178 GO:0030282 GO:0007155 GO:0001649 | |
| Gene3D | 2.60.40.670 | |
| InterPro | IPR022409 IPR000601 | |
| Pfam | PF00801 | |
| SMART | SM00089 | |
| SUPFAM | SSF49299 | |
| PROSITE | PS50093 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000315 |
P |
Figure 9 |
complete | |||||
| GO:0032695 |
negative regulation of interleukin-12 production |
ECO:0000315 |
P |
Figure 9 |
complete | |||||
| GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000315 |
P |
Figure 9 |
complete | |||||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P28862) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000305 |
curator inference used in manual assertion |
GO:0001934 |
P |
occurs_in:(UBERON:0000955) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034103 |
regulation of tissue remodeling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1934765 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1934765 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005178 |
integrin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1934765 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000134 |
negative regulation of G1/S transition of mitotic cell cycle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1901215 |
negative regulation of neuron death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050868 |
negative regulation of T cell activation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048018 |
receptor ligand activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0045545 |
syndecan binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042130 |
negative regulation of T cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0034103 |
regulation of tissue remodeling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031954 |
positive regulation of protein autophosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030335 |
positive regulation of cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008201 |
heparin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008201 |
heparin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007267 |
cell-cell signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007165 |
signal transduction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007155 |
cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005178 |
integrin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001818 |
negative regulation of cytokine production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0048018 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0048018 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000134 |
negative regulation of G1/S transition of mitotic cell cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901215 |
negative regulation of neuron death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050868 |
negative regulation of T cell activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048018 |
receptor ligand activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0045545 |
syndecan binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042130 |
negative regulation of T cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034103 |
regulation of tissue remodeling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031954 |
positive regulation of protein autophosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008201 |
heparin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007267 |
cell-cell signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001818 |
negative regulation of cytokine production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14956 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030282 |
bone mineralization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6P7C7 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001649 |
osteoblast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6P7C7 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031901 |
early endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033162 |
melanosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Ripoll, VM et al. (2007) Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. J. Immunol. 178 6557-66 PubMed GONUTS page
- ↑ 2.0 2.1 Furochi, H et al. (2007) Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression via ERK pathway in mouse NIH-3T3 fibroblasts. FEBS Lett. 581 5743-50 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Nakano, Y et al. (2014) Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia-reperfusion injury. Neuroscience 277 123-31 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Bächner, D et al. (2002) mRNA expression of the murine glycoprotein (transmembrane) nmb (Gpnmb) gene is linked to the developing retinal pigment epithelium and iris. Brain Res. Gene Expr. Patterns 1 159-65 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Shikano, S et al. (2001) Molecular cloning of a dendritic cell-associated transmembrane protein, DC-HIL, that promotes RGD-dependent adhesion of endothelial cells through recognition of heparan sulfate proteoglycans. J. Biol. Chem. 276 8125-34 PubMed GONUTS page
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- GO:0032715 ! negative regulation of interleukin-6 production
- GO:0032695 ! negative regulation of interleukin-12 production
- GO:0032720 ! negative regulation of tumor necrosis factor production
- GO:0001818 ! negative regulation of cytokine production
- GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle
- GO:0050868 ! negative regulation of T cell activation
- GO:0042130 ! negative regulation of T cell proliferation
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