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MOUSE:GABR2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Gabbr2 (synonyms: Gm425, Gpr51)
Protein Name(s) Gamma-aminobutyric acid type B receptor subunit 2

GABA-B receptor 2 GABA-B-R2 GABA-BR2 GABABR2 Gb2 G-protein coupled receptor 51

External Links
UniProt Q80T41
EMBL AL772399
AL831741
AL844224
BX005247
BX571848
AL831741
AL772399
AL844224
BX005247
BX571848
BX005247
AL772399
AL831741
AL844224
BX571848
BX571848
AL772399
AL831741
AL844224
BX005247
AL844224
AL772399
AL831741
BX005247
BX571848
AY255605
CCDS CCDS38758.1
RefSeq NP_001074610.1
UniGene Mm.101909
ProteinModelPortal Q80T41
SMR Q80T41
BioGrid 232404
IntAct Q80T41
PhosphoSite Q80T41
MaxQB Q80T41
PaxDb Q80T41
PRIDE Q80T41
Ensembl ENSMUST00000107749
GeneID 242425
KEGG mmu:242425
UCSC uc008sug.1
CTD 9568
MGI MGI:2386030
eggNOG NOG273984
GeneTree ENSGT00530000063129
HOGENOM HOG000112688
HOVERGEN HBG080355
InParanoid Q80T41
KO K04615
OMA TAMEGYI
OrthoDB EOG7D2FCV
PhylomeDB Q80T41
TreeFam TF313965
Reactome REACT_208837
REACT_217868
REACT_226457
REACT_250376
REACT_262510
NextBio 385343
PRO PR:Q80T41
Proteomes UP000000589
Bgee Q80T41
CleanEx MM_GABBR2
Genevestigator Q80T41
GO GO:0030054
GO:0005737
GO:0038039
GO:0005887
GO:0043005
GO:0045211
GO:0004965
GO:0007214
InterPro IPR001828
IPR002455
IPR000337
IPR017978
IPR017979
IPR002457
IPR028082
PANTHER PTHR10519
Pfam PF00003
PF01094
PRINTS PR01178
PR00248
SUPFAM SSF53822
PROSITE PS00981
PS50259

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007214

gamma-aminobutyric acid signaling pathway

PMID:22504960[1]

ECO:0000314

P

Figure 6B

complete
CACAO 5751

GO:0004965

G-protein coupled GABA receptor activity

PMID:22504960[1]

ECO:0000314

F

Figure 6B

complete
CACAO 5752

part_of

GO:0038039

G protein-coupled receptor heterodimeric complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75899

C

Seeded From UniProt

complete

involved_in

GO:0007214

gamma-aminobutyric acid signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75899

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75899

C

Seeded From UniProt

complete

part_of

GO:0038039

G protein-coupled receptor heterodimeric complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0260446
PANTHER:PTN000828857
UniProtKB:A0A0B4LHR4
UniProtKB:O75899
UniProtKB:Q9UBS5

C

Seeded From UniProt

complete

involved_in

GO:0007214

gamma-aminobutyric acid signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0260446
MGI:MGI:1860139
PANTHER:PTN000054983
RGD:619864
UniProtKB:A0A0B4LHR4
UniProtKB:O75899
UniProtKB:Q9UBS5
dictyBase:DDB_G0291356

P

Seeded From UniProt

complete

enables

GO:0004965

G protein-coupled GABA receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0260446
PANTHER:PTN000054983
RGD:619864
RGD:621537
UniProtKB:A0A0B4LHR4
UniProtKB:O75899
UniProtKB:Q9UBS5
WB:WBGene00021528
WB:WBGene00022675
dictyBase:DDB_G0291356

F

Seeded From UniProt

complete

part_of

GO:1902710

GABA receptor complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75899

C

Seeded From UniProt

complete

part_of

GO:0099056

integral component of presynaptic membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619864

C

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619864

C

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619864

C

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619864

C

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75899

F

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:15013631[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0038039

G protein-coupled receptor heterodimeric complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75899

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007214

gamma-aminobutyric acid signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75899

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007214

gamma-aminobutyric acid signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619864

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75899

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15013631[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004965

G protein-coupled GABA receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619864

F

Seeded From UniProt

complete

contributes_to

GO:0004965

G protein-coupled GABA receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75899

F

Seeded From UniProt

complete

part_of

GO:1902710

GABA receptor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75899
ensembl:ENSP00000259455

C

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75899
ensembl:ENSP00000259455

F

Seeded From UniProt

complete

part_of

GO:0038039

G protein-coupled receptor heterodimeric complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75899
ensembl:ENSP00000259455

C

Seeded From UniProt

complete

involved_in

GO:0007214

gamma-aminobutyric acid signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75899
ensembl:ENSP00000259455

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75899
ensembl:ENSP00000259455

C

Seeded From UniProt

complete

enables

GO:0004965

G protein-coupled GABA receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O75899
ensembl:ENSP00000259455

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000337
InterPro:IPR017978
InterPro:IPR017979

F

Seeded From UniProt

complete

enables

GO:0004965

G protein-coupled GABA receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002455
InterPro:IPR002457

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000337
InterPro:IPR002455
InterPro:IPR002457
InterPro:IPR017978
InterPro:IPR017979

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000337
InterPro:IPR002455
InterPro:IPR002457
InterPro:IPR017978
InterPro:IPR017979

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0045211

postsynaptic membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0628
UniProtKB-SubCell:SL-0219

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Kurokawa, K et al. (2012) Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons. J. Neurosci. Res. 90 1626-38 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 Ritter, B et al. (2004) The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development. Brain Res. Dev. Brain Res. 149 73-7 PubMed GONUTS page
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