MOUSE:FGFR4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fgfr4 (synonyms: Fgfr-4, Mpk-11)
Protein Name(s)	Fibroblast growth factor receptor 4 FGFR-4 Protein-tyrosine kinase receptor MPK-11
External Links
UniProt	Q03142
EMBL	X59927 DQ388428 AY493377 AK084850 BC033313 X57236
CCDS	CCDS26540.1
PIR	S18209
RefSeq	NP_032037.2
UniGene	Mm.276715
ProteinModelPortal	Q03142
SMR	Q03142
BioGrid	199660
DIP	DIP-58508N
BindingDB	Q03142
ChEMBL	CHEMBL2111391
MEROPS	I43.001
PhosphoSite	Q03142
PaxDb	Q03142
PRIDE	Q03142
Ensembl	ENSMUST00000005452
GeneID	14186
KEGG	mmu:14186
UCSC	uc007qqb.1 uc011yzq.1
CTD	2264
MGI	MGI:95525
eggNOG	COG0515
GeneTree	ENSGT00760000118923
HOGENOM	HOG000263410
HOVERGEN	HBG000345
InParanoid	Q03142
KO	K05095
OrthoDB	EOG7NGQ9N
PhylomeDB	Q03142
TreeFam	TF316307
BRENDA	2.7.10.1
Reactome	REACT_196455 REACT_196510 REACT_196588 REACT_198525 REACT_199063 REACT_206694 REACT_223993 REACT_226341 REACT_230708 REACT_234357 REACT_240139 REACT_94437
NextBio	285398
PRO	PR:Q03142
Proteomes	UP000000589
Bgee	Q03142
CleanEx	MM_FGFR4
Genevestigator	Q03142
GO	GO:0005911 GO:0005783 GO:0005768 GO:0005887 GO:0005634 GO:0005524 GO:0017134 GO:0005007 GO:0008201 GO:0061144 GO:0016477 GO:0008543 GO:0042593 GO:0030324 GO:0001759 GO:0018108 GO:0055062 GO:0008284 GO:2000573 GO:0070374 GO:0048554 GO:0045862 GO:0046777 GO:0070857 GO:2000188 GO:0010715 GO:0019216
Gene3D	2.60.40.10
InterPro	IPR016248 IPR007110 IPR013783 IPR013098 IPR003598 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635
Pfam	PF07679 PF07714
PIRSF	PIRSF000628
PRINTS	PR00109
SMART	SM00408 SM00219
SUPFAM	SSF56112
PROSITE	PS50835 PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0070857	regulation of bile acid biosynthetic process	PMID:10809780^[1]	ECO:0000315			P		figure 2-acceleration of bile acid synthesis by blocking bile acid feedback inhibition can accelerate gallbladder emptying and a decrease in gallbladder volume.	complete CACAO 6540
	GO:0016301	kinase activity	PMID:14739300^[2]	ECO:0000315			F		figure 3- the results suggest that the presence of kinase activity of Src is necessary for actin ring formation and bone resorption	complete CACAO 6546
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:10809780^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070857	regulation of bile acid biosynthetic process	PMID:10809780^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
involved_in	GO:0055062	phosphate ion homeostasis	PMID:21561999^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
involved_in	GO:0045862	positive regulation of proteolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:17664243^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	PMID:17664243^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
involved_in	GO:0010715	regulation of extracellular matrix disassembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	F		Seeded From UniProt	complete
colocalizes_with	GO:0005911	cell-cell junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	C		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22455	F		Seeded From UniProt	complete
involved_in	GO:0070857	regulation of bile acid biosynthetic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95525 PANTHER:PTN000699343 UniProtKB:P22455	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699343 UniProtKB:P22455	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95523 PANTHER:PTN000699279 RGD:2611 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 ZFIN:ZDB-GENE-030323-1	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 PANTHER:PTN001230353 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 PANTHER:PTN001562203 RGD:620713 UniProtKB:P11362 ZFIN:ZDB-GENE-980526-255	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95524 PANTHER:PTN000699279 RGD:2611 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000830	positive regulation of parathyroid hormone secretion	PMID:24259513^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090272	negative regulation of fibroblast growth factor production	PMID:24259513^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070857	regulation of bile acid biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070640	vitamin D3 metabolic process	PMID:24259513^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061144	alveolar secondary septum development	PMID:9716527^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95524	P	results_in_development_of:(EMAPA:35433)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051174	regulation of phosphorus metabolic process	PMID:24259513^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045862	positive regulation of proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043085	positive regulation of catalytic activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:15576401^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(EMAPA:16728)	Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010966	regulation of phosphate transport	PMID:24259513^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010715	regulation of extracellular matrix disassembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:24259513^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:18187602^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O95750 UniProtKB:P05230	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q498D6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:18187602^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O95750 UniProtKB:P05230	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	F		Seeded From UniProt	complete
colocalizes_with	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	C		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q498D6	F		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P22455	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001759	organ induction	PMID:15576401^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR016248 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR016248 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Yu, C et al. (2000) Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J. Biol. Chem. 275 15482-9 PubMed GONUTS page
↑ Miyazaki, T et al. (2004) Src kinase activity is essential for osteoclast function. J. Biol. Chem. 279 17660-6 PubMed GONUTS page
↑ Gattineni, J et al. (2011) Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4. Am. J. Physiol. Renal Physiol. 301 F371-7 PubMed GONUTS page
↑ ^4.0 ^4.1 Huang, X et al. (2007) FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes 56 2501-10 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gattineni, J et al. (2014) Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4. Am. J. Physiol. Renal Physiol. 306 F351-8 PubMed GONUTS page
↑ Weinstein, M et al. (1998) FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development 125 3615-23 PubMed GONUTS page
↑ ^8.0 ^8.1 Serls, AE et al. (2005) Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development 132 35-47 PubMed GONUTS page
↑ ^9.0 ^9.1 Suzuki, M et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol. Endocrinol. 22 1006-14 PubMed GONUTS page

[PMID:10809780-1] 1.0 ^1.1 ^1.2 Yu, C et al. (2000) Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J. Biol. Chem. 275 15482-9 PubMed GONUTS page

[PMID:14739300-2] Miyazaki, T et al. (2004) Src kinase activity is essential for osteoclast function. J. Biol. Chem. 279 17660-6 PubMed GONUTS page

[PMID:21561999-3] Gattineni, J et al. (2011) Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4. Am. J. Physiol. Renal Physiol. 301 F371-7 PubMed GONUTS page

[PMID:17664243-4] 4.0 ^4.1 Huang, X et al. (2007) FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes 56 2501-10 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24259513-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gattineni, J et al. (2014) Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4. Am. J. Physiol. Renal Physiol. 306 F351-8 PubMed GONUTS page

[PMID:9716527-7] Weinstein, M et al. (1998) FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development 125 3615-23 PubMed GONUTS page

[PMID:15576401-8] 8.0 ^8.1 Serls, AE et al. (2005) Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development 132 35-47 PubMed GONUTS page

[PMID:18187602-9] 9.0 ^9.1 Suzuki, M et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol. Endocrinol. 22 1006-14 PubMed GONUTS page

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MOUSE:FGFR4

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