MOUSE:FGF7

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fgf7 (synonyms: Fgf-7, Kgf)
Protein Name(s)	Fibroblast growth factor 7 FGF-7 Heparin-binding growth factor 7 HBGF-7 Keratinocyte growth factor KGF
External Links
UniProt	P36363
EMBL	Z22703 U58503 BC052847
CCDS	CCDS16681.1
PIR	I48610
RefSeq	NP_032034.1
UniGene	Mm.330557
ProteinModelPortal	P36363
SMR	P36363
BioGrid	199652
IntAct	P36363
STRING	10090.ENSMUSP00000106072
PhosphoSite	P36363
PRIDE	P36363
Ensembl	ENSMUST00000064794 ENSMUST00000110442
GeneID	14178
KEGG	mmu:14178
UCSC	uc008mdj.2
CTD	2252
MGI	MGI:95521
eggNOG	NOG294282
HOGENOM	HOG000236341
HOVERGEN	HBG007580
InParanoid	P36363
KO	K04358
OMA	NCSKHER
OrthoDB	EOG7992S1
PhylomeDB	P36363
TreeFam	TF317805
Reactome	REACT_196455 REACT_196536 REACT_196588 REACT_198525 REACT_223937 REACT_223993 REACT_226341 REACT_230708 REACT_234357 REACT_240139 REACT_94437
NextBio	285362
PRO	PR:P36363
Proteomes	UP000000589
Bgee	P36363
CleanEx	MM_FGF7
ExpressionAtlas	P36363
Genevestigator	P36363
GO	GO:0005576 GO:0005794 GO:0042056 GO:0008201 GO:0031532 GO:0060445 GO:0008543 GO:0031069 GO:0010463 GO:0051781 GO:0008284 GO:0050679 GO:0060501 GO:0051549 GO:0010838 GO:0050731 GO:0034394 GO:0060665 GO:0061033
InterPro	IPR008996 IPR028247 IPR002209 IPR028142
PANTHER	PTHR11486 PTHR11486:SF20
PRINTS	PR00263 PR00262
SMART	SM00442
SUPFAM	SSF50353
PROSITE	PS00247

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:17394208^[1]	ECO:0000314			P	Fig 5.	complete CACAO 6699
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17394208^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061033	secretion by lung epithelial cell involved in lung growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	PMID:18559345^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060445	branching involved in salivary gland morphogenesis	PMID:18559345^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051549	positive regulation of keratinocyte migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050918	positive chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	PMID:17187775^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	PMID:11493558^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61805	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043129	surfactant homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61805	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042060	wound healing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61805	P	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034394	protein localization to cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031069	hair follicle morphogenesis	PMID:11098134^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61805	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010838	positive regulation of keratinocyte proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010463	mesenchymal cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008654	phospholipid biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61805	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:15806171^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:15806171^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:14697353^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21781	P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61805	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61805	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006656	phosphatidylcholine biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61805	P	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:12837279^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61805	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:12837279^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005111	type 2 fibroblast growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61805	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001541	ovarian follicle development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61805	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0061033	secretion by lung epithelial cell involved in lung growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	P	Seeded From UniProt	complete
involved_in	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	P	Seeded From UniProt	complete
involved_in	GO:0051549	positive regulation of keratinocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	P	Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	P	Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	P	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	F	Seeded From UniProt	complete
involved_in	GO:0034394	protein localization to cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	P	Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	P	Seeded From UniProt	complete
involved_in	GO:0010838	positive regulation of keratinocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	P	Seeded From UniProt	complete
involved_in	GO:0010463	mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	P	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21781 ensembl:ENSP00000267843	P	Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028247	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028247	C	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002209	F	Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028247	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Metzger, DE et al. (2007) Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung. Dev. Dyn. 236 1175-92 PubMed GONUTS page
↑ ^2.0 ^2.1 Yamamoto, S et al. (2008) Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J. Biol. Chem. 283 23139-49 PubMed GONUTS page
↑ van Tuyl, M et al. (2007) Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs. Dev. Biol. 303 514-26 PubMed GONUTS page
↑ Mahlapuu, M et al. (2001) Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development 128 2397-406 PubMed GONUTS page
↑ Kato, H et al. (2000) Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons. J. Biochem. 128 923-32 PubMed GONUTS page
↑ ^6.0 ^6.1 Beer, HD et al. (2005) The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Oncogene 24 5269-77 PubMed GONUTS page
↑ Burns, RC et al. (2004) Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse. Dev. Biol. 265 61-74 PubMed GONUTS page
↑ ^8.0 ^8.1 Beyer, TA et al. (2003) Fibroblast growth factor 22 and its potential role during skin development and repair. Exp. Cell Res. 287 228-36 PubMed GONUTS page

[PMID:17394208-1] 1.0 ^1.1 Metzger, DE et al. (2007) Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung. Dev. Dyn. 236 1175-92 PubMed GONUTS page

[PMID:18559345-2] 2.0 ^2.1 Yamamoto, S et al. (2008) Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J. Biol. Chem. 283 23139-49 PubMed GONUTS page

[PMID:17187775-3] van Tuyl, M et al. (2007) Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs. Dev. Biol. 303 514-26 PubMed GONUTS page

[PMID:11493558-4] Mahlapuu, M et al. (2001) Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development 128 2397-406 PubMed GONUTS page

[PMID:11098134-5] Kato, H et al. (2000) Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons. J. Biochem. 128 923-32 PubMed GONUTS page

[PMID:15806171-6] 6.0 ^6.1 Beer, HD et al. (2005) The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Oncogene 24 5269-77 PubMed GONUTS page

[PMID:14697353-7] Burns, RC et al. (2004) Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse. Dev. Biol. 265 61-74 PubMed GONUTS page

[PMID:12837279-8] 8.0 ^8.1 Beyer, TA et al. (2003) Fibroblast growth factor 22 and its potential role during skin development and repair. Exp. Cell Res. 287 228-36 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

MOUSE:FGF7

Contents

Annotations

Notes

References

b

c

e

f

g

h

l

m

o

p

r

s

t

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools