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MOUSE:FGF21
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Fgf21 | |
| Protein Name(s) | Fibroblast growth factor 21
FGF-21 | |
| External Links | ||
| UniProt | Q9JJN1 | |
| EMBL | AB025718 AK007574 BC049592 | |
| CCDS | CCDS21253.1 | |
| RefSeq | NP_064397.1 | |
| UniGene | Mm.143736 | |
| ProteinModelPortal | Q9JJN1 | |
| SMR | Q9JJN1 | |
| DIP | DIP-60919N | |
| STRING | 10090.ENSMUSP00000033099 | |
| PRIDE | Q9JJN1 | |
| Ensembl | ENSMUST00000033099 | |
| GeneID | 56636 | |
| KEGG | mmu:56636 | |
| UCSC | uc009gwe.1 | |
| CTD | 26291 | |
| MGI | MGI:1861377 | |
| eggNOG | NOG311125 | |
| GeneTree | ENSGT00530000063469 | |
| HOGENOM | HOG000112572 | |
| HOVERGEN | HBG051612 | |
| InParanoid | Q9JJN1 | |
| KO | K04358 | |
| OMA | TLYGSLH | |
| OrthoDB | EOG7X6M1F | |
| PhylomeDB | Q9JJN1 | |
| TreeFam | TF335872 | |
| NextBio | 313077 | |
| PRO | PR:Q9JJN1 | |
| Proteomes | UP000000589 | |
| Bgee | Q9JJN1 | |
| CleanEx | MM_FGF21 | |
| Genevestigator | Q9JJN1 | |
| GO | GO:0005576 GO:0008284 GO:0070374 GO:0046326 GO:0090080 | |
| InterPro | IPR008996 IPR028292 IPR002209 IPR028142 | |
| PANTHER | PTHR11486 PTHR11486:SF62 | |
| PRINTS | PR00263 PR00262 | |
| SMART | SM00442 | |
| SUPFAM | SSF50353 | |
| PROSITE | PS00247 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000352 |
negative regulation of endothelial cell apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620175 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1901215 |
negative regulation of neuron death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620175 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090080 |
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1932466 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046326 |
positive regulation of glucose import |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010898 |
positive regulation of triglyceride catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620175 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1932466 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620175 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000352 |
negative regulation of endothelial cell apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904640 |
response to methionine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901215 |
negative regulation of neuron death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0072577 |
endothelial cell apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071404 |
cellular response to low-density lipoprotein particle stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071377 |
cellular response to glucagon stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071333 |
cellular response to glucose stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035690 |
cellular response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031667 |
response to nutrient levels |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030968 |
endoplasmic reticulum unfolded protein response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014823 |
response to activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010898 |
positive regulation of triglyceride catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VI80 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NSA1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046326 |
positive regulation of glucose import |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NSA1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005104 |
fibroblast growth factor receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008543 |
fibroblast growth factor receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-MMU-6784616 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Fisher, FM et al. (2012) FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26 271-81 PubMed GONUTS page
- ↑ 2.0 2.1 Suzuki, M et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol. Endocrinol. 22 1006-14 PubMed GONUTS page
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- GO:0008284 ! positive regulation of cell population proliferation
- GO:0010898 ! positive regulation of triglyceride catabolic process
- GO:0046326 ! positive regulation of D-glucose import
- GO:0070374 ! positive regulation of ERK1 and ERK2 cascade
- GO:0090080 ! positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
- GO:0120162 ! positive regulation of cold-induced thermogenesis
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