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MOUSE:F8VPS6

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) No Information Provided.
Protein Name(s) Protein Plekhg4 (ECO:0000313 with Ensembl:ENSMUSP00000014927)
External Links
UniProt F8VPS6
EMBL AC124584
RefSeq NP_001074802.1
UniGene Mm.32034
ProteinModelPortal F8VPS6
SMR F8VPS6
PRIDE F8VPS6
Ensembl ENSMUST00000014927
GeneID 102075
KEGG mmu:102075
UCSC uc009ncw.1
CTD 25894
MGI MGI:2142544
GeneTree ENSGT00760000119030
InParanoid F8VPS6
OMA LQPLAGW
TreeFam TF334329
NextBio 355260
PRO PR:F8VPS6
Proteomes UP000000589
Bgee F8VPS6
ExpressionAtlas F8VPS6
GO GO:0005089
Gene3D 1.20.900.10
2.30.29.30
InterPro IPR000219
IPR001849
IPR011993
Pfam PF00621
SMART SM00233
SM00325
SUPFAM SSF48065
PROSITE PS50010
PS50003

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032956

regulation of actin cytoskeleton organization

PMID:23572525[1]

ECO:0000315

P

Insets of fluorescent microscopy in Fig. 4 show cytoskeletal features exhibited by Plekhg4 expression, demonstrating how it plays a role in the regulation the actin cytoskeleton

complete
CACAO 7969

involved_in

GO:0090630

activation of GTPase activity

PMID:23572525[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0090630

activation of GTPase activity

PMID:23572525[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Plekhg4-GTPase association is demonstrated in Fig 3. B, and the GTPase activation by Plekhg4 is shown in Fig 3. A. Together these results demonstrate Plekhg4’s GEF function.

complete
CACAO 7980

part_of

GO:0005575

cellular_component

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003674

molecular_function

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005089

Rho guanyl-nucleotide exchange factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000219

F

Seeded From UniProt

complete

involved_in

GO:0035023

regulation of Rho protein signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000219

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Gupta, M et al. (2013) Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases. J. Biol. Chem. 288 14522-30 PubMed GONUTS page