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MOUSE:ESPN

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Espn
Protein Name(s) Espin

Ectoplasmic specialization protein

External Links
UniProt Q9ET47
EMBL AF239886
AF540942
AF540943
AF540944
AF540945
AY587570
AY587571
AF134858
AL772240
AL772240
AL772240
AL772240
AL772240
AL772240
CCDS CCDS18989.1
CCDS18990.1
CCDS18991.1
CCDS18992.1
CCDS18993.1
CCDS18994.1
RefSeq NP_997570.1
NP_997571.1
NP_997572.1
NP_997573.1
NP_997574.2
UniGene Mm.264215
ProteinModelPortal Q9ET47
SMR Q9ET47
IntAct Q9ET47
MINT MINT-258237
PhosphoSite Q9ET47
MaxQB Q9ET47
PaxDb Q9ET47
PRIDE Q9ET47
Ensembl ENSMUST00000030785
ENSMUST00000070018
ENSMUST00000080042
ENSMUST00000084114
ENSMUST00000105653
ENSMUST00000105657
GeneID 56226
KEGG mmu:56226
UCSC uc008vzn.1
uc008vzo.1
uc008vzp.1
uc008vzq.1
uc008vzr.1
uc008vzs.1
uc008vzt.1
CTD 83715
MGI MGI:1861630
eggNOG COG0666
GeneTree ENSGT00600000084407
HOVERGEN HBG100662
InParanoid Q9ET47
OrthoDB EOG7353WF
PhylomeDB Q9ET47
TreeFam TF326392
NextBio 312114
PRO PR:Q9ET47
Proteomes UP000000589
Bgee Q9ET47
ExpressionAtlas Q9ET47
Genevestigator Q9ET47
GO GO:0015629
GO:0005903
GO:0030054
GO:0005737
GO:0043197
GO:0031941
GO:0032420
GO:0032421
GO:0032426
GO:0051015
GO:0017124
GO:0051017
GO:0051639
GO:0007626
GO:0051494
GO:0030046
GO:0051491
GO:0007605
Gene3D 1.25.40.20
InterPro IPR002110
IPR020683
IPR030233
IPR003124
PANTHER PTHR24153:SF14
Pfam PF00023
PF12796
PF02205
SMART SM00248
SM00246
SUPFAM SSF48403
PROSITE PS50297
PS50088
PS51082

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0032426

stereocilium tip

PMID:26754646[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005903

brush border

PMID:22114352[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000584)

Seeded From UniProt

complete

involved_in

GO:0051639

actin filament network formation

PMID:15024034[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051494

negative regulation of cytoskeleton organization

PMID:15190118[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63618

F

Seeded From UniProt

complete

part_of

GO:0031941

filamentous actin

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63618

C

Seeded From UniProt

complete

enables

GO:0017124

SH3 domain binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63618

F

Seeded From UniProt

complete

part_of

GO:0005903

brush border

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63618

C

Seeded From UniProt

complete

involved_in

GO:0051017

actin filament bundle assembly

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0262111
MGI:MGI:1861630
PANTHER:PTN001192625

P

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2685402
PANTHER:PTN001192625
RGD:620652

F

Seeded From UniProt

complete

colocalizes_with

GO:0031941

filamentous actin

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001192625
RGD:620652

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001192625
RGD:620652
WB:WBGene00009801

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051491

positive regulation of filopodium assembly

PMID:22264607[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q1EG27

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051491

positive regulation of filopodium assembly

PMID:22264607[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2183924

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051017

actin filament bundle assembly

PMID:10588661[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620652

F

Seeded From UniProt

complete

part_of

GO:0032426

stereocilium tip

PMID:26754646[1]

ECO:0005804

immunofluorescence evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032426

stereocilium tip

PMID:22264607[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000589)

Seeded From UniProt

complete

part_of

GO:0032421

stereocilium bundle

PMID:20016102[8]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000589)

Seeded From UniProt

complete

part_of

GO:0032420

stereocilium

PMID:20510926[9]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000202)

Seeded From UniProt

complete

part_of

GO:0031941

filamentous actin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620652

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030046

parallel actin filament bundle assembly

PMID:10588661[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0017124

SH3 domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620652

F

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

PMID:10588661[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q63618

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:16962269[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1856573

P

Seeded From UniProt

complete

part_of

GO:0005903

brush border

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620652

C

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q63618

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q63618

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003124
InterPro:IPR030233

F

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030233

F

Seeded From UniProt

complete

involved_in

GO:0051017

actin filament bundle assembly

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030233

P

Seeded From UniProt

complete

part_of

GO:0005903

brush border

PMID:10975527[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965
UniProtKB-SubCell:SL-0038

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1009

P

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0293

C

Seeded From UniProt

complete

part_of

GO:0043197

dendritic spine

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0284

C

Seeded From UniProt

complete

part_of

GO:0032420

stereocilium

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0302

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Lelli, A et al. (2016) Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. J. Cell Biol. 212 231-44 PubMed GONUTS page
  2. ↑ Revenu, C et al. (2012) A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Mol. Biol. Cell 23 324-36 PubMed GONUTS page
  3. ↑ Rzadzinska, AK et al. (2004) An actin molecular treadmill and myosins maintain stereocilia functional architecture and self-renewal. J. Cell Biol. 164 887-97 PubMed GONUTS page
  4. ↑ Sekerková, G et al. (2004) Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells. J. Neurosci. 24 5445-56 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Merritt, RC et al. (2012) Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Curr. Biol. 22 320-5 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Chen, B et al. (1999) Espin contains an additional actin-binding site in its N terminus and is a major actin-bundling protein of the Sertoli cell-spermatid ectoplasmic specialization junctional plaque. Mol. Biol. Cell 10 4327-39 PubMed GONUTS page
  8. ↑ Grimsley-Myers, CM et al. (2009) The small GTPase Rac1 regulates auditory hair cell morphogenesis. J. Neurosci. 29 15859-69 PubMed GONUTS page
  9. ↑ Kitajiri, S et al. (2010) Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell 141 786-98 PubMed GONUTS page
  10. ↑ Calderon, A et al. (2006) Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hear. Res. 221 44-58 PubMed GONUTS page
  11. ↑ Zheng, L et al. (2000) The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins. Cell 102 377-85 PubMed GONUTS page
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