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MOUSE:ERD21

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Kdelr1
Protein Name(s) ER lumen protein-retaining receptor 1

KDEL endoplasmic reticulum protein retention receptor 1 KDEL receptor 1

External Links
UniProt Q99JH8
EMBL AY027435
AJ278132
BC011370
CCDS CCDS21268.1
RefSeq NP_598711.1
UniGene Mm.298433
STRING 10090.ENSMUSP00000002855
PhosphoSitePlus Q99JH8
MaxQB Q99JH8
PaxDb Q99JH8
PeptideAtlas Q99JH8
PRIDE Q99JH8
TopDownProteomics Q99JH8
Ensembl ENSMUST00000002855
GeneID 68137
KEGG mmu:68137
UCSC uc009gxn.1
CTD 10945
MGI MGI:1915387
eggNOG KOG3106
COG5196
GeneTree ENSGT00390000004010
HOGENOM HOG000231400
HOVERGEN HBG001398
InParanoid Q99JH8
KO K10949
OMA LMFFKFR
OrthoDB EOG091G0Q1H
PhylomeDB Q99JH8
TreeFam TF314792
Reactome R-MMU-6807878
R-MMU-6811434
ChiTaRS Kdelr1
PRO PR:Q99JH8
Proteomes UP000000589
Bgee ENSMUSG00000002778
ExpressionAtlas Q99JH8
Genevisible Q99JH8
GO GO:0005801
GO:0030663
GO:0005783
GO:0005789
GO:0005793
GO:0033116
GO:0005794
GO:0016021
GO:0046923
GO:0006888
GO:0006621
GO:0015031
GO:0070231
GO:0002369
GO:0030217
InterPro IPR000133
PANTHER PTHR10585
Pfam PF00810
PRINTS PR00660
PROSITE PS00951
PS00952

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0000139

Golgi membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24390

C

Seeded From UniProt

complete

enables

GO:0005046

KDEL sequence binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24390

F

Seeded From UniProt

complete

involved_in

GO:0006890

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P24390

P

Seeded From UniProt

complete

involved_in

GO:0006888

endoplasmic reticulum to Golgi vesicle-mediated transport

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000062353
SGD:S000000136

P

Seeded From UniProt

complete

involved_in

GO:0006621

protein retention in ER lumen

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0267330
PANTHER:PTN000062353
SGD:S000000136
TAIR:locus:2013683

P

Seeded From UniProt

complete

part_of

GO:0005801

cis-Golgi network

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915387
PANTHER:PTN000062353
RGD:1304618
RGD:1306764
TAIR:locus:2013683
UniProtKB:Q76NM1

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915387
PANTHER:PTN000062353
TAIR:locus:2013683
TAIR:locus:2086954
UniProtKB:Q76NM1

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915387
PANTHER:PTN000062353
RGD:1304618
RGD:1306764
TAIR:locus:2013683
UniProtKB:O43731

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070231

T cell apoptotic process

PMID:26438836[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5689886

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030217

T cell differentiation

PMID:26438836[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5689886

P

Seeded From UniProt

complete

part_of

GO:0005801

cis-Golgi network

PMID:21187406[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005801

cis-Golgi network

PMID:19474315[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q569A6

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:15084279[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005793

endoplasmic reticulum-Golgi intermediate compartment

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P24390

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:24191021[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:19474315[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q569A6

C

Seeded From UniProt

complete

enables

GO:0003674

molecular_function

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002369

T cell cytokine production

PMID:26438836[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5689886

P

Seeded From UniProt

complete

part_of

GO:0030663

COPI-coated vesicle membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24390
ensembl:ENSP00000329471

C

Seeded From UniProt

complete

involved_in

GO:0006890

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24390
ensembl:ENSP00000329471

P

Seeded From UniProt

complete

part_of

GO:0005793

endoplasmic reticulum-Golgi intermediate compartment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24390
ensembl:ENSP00000329471

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24390
ensembl:ENSP00000329471

C

Seeded From UniProt

complete

enables

GO:0005046

KDEL sequence binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24390
ensembl:ENSP00000329471

F

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P24390
ensembl:ENSP00000329471

C

Seeded From UniProt

complete

part_of

GO:0005801

cis-Golgi network

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q569A6
ensembl:ENSRNOP00000028627

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q569A6
ensembl:ENSRNOP00000028627

C

Seeded From UniProt

complete

involved_in

GO:0006621

protein retention in ER lumen

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000133

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000133

C

Seeded From UniProt

complete

enables

GO:0046923

ER retention sequence binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000133

F

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0931

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0030663

COPI-coated vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0076

C

Seeded From UniProt

complete

part_of

GO:0033116

endoplasmic reticulum-Golgi intermediate compartment membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0099

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 Siggs, OM et al. (2015) Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection. Proc. Natl. Acad. Sci. U.S.A. 112 E5706-14 PubMed GONUTS page
  3. Valkova, C et al. (2011) Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits. Proc. Natl. Acad. Sci. U.S.A. 108 621-5 PubMed GONUTS page
  4. 4.0 4.1 Rezvani, K et al. (2009) UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. J. Neurosci. 29 6883-96 PubMed GONUTS page
  5. Butkevich, E et al. (2004) Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton. Curr. Biol. 14 650-8 PubMed GONUTS page
  6. Rockich, BE et al. (2013) Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 110 E4456-64 PubMed GONUTS page