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MOUSE:EPCR
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Procr (synonyms: Epcr) | |
| Protein Name(s) | Endothelial protein C receptor
Activated protein C receptor APC receptor Centrocyclin Centrosomal protein CCD41 Endothelial cell protein C receptor | |
| External Links | ||
| UniProt | Q64695 | |
| EMBL | X63748 L39017 AF162695 AK143719 AK167302 CT010175 AL929233 CH466551 | |
| CCDS | CCDS16954.1 | |
| PIR | A55945 S18948 | |
| RefSeq | NP_035301.2 | |
| UniGene | Mm.3243 | |
| ProteinModelPortal | Q64695 | |
| SMR | Q64695 | |
| IntAct | Q64695 | |
| MINT | MINT-4094503 | |
| MaxQB | Q64695 | |
| PaxDb | Q64695 | |
| PRIDE | Q64695 | |
| Ensembl | ENSMUST00000029140 | |
| GeneID | 19124 | |
| KEGG | mmu:19124 | |
| UCSC | uc008nlh.2 | |
| CTD | 10544 | |
| MGI | MGI:104596 | |
| eggNOG | NOG44455 | |
| GeneTree | ENSGT00390000001159 | |
| HOGENOM | HOG000059633 | |
| HOVERGEN | HBG005593 | |
| InParanoid | Q64695 | |
| KO | K06557 | |
| OMA | THVLEGP | |
| OrthoDB | EOG7F5131 | |
| TreeFam | TF335868 | |
| Reactome | REACT_225233 REACT_259461 | |
| NextBio | 295726 | |
| PRO | PR:Q64695 | |
| Proteomes | UP000000589 | |
| CleanEx | MM_PROCR | |
| ExpressionAtlas | Q64695 | |
| Genevestigator | Q64695 | |
| GO | GO:0005813 GO:0070062 GO:0016021 GO:0008022 GO:0019882 GO:0007596 GO:0006955 GO:0050819 | |
| Gene3D | 3.30.500.10 | |
| InterPro | IPR015669 IPR011161 IPR011162 | |
| PANTHER | PTHR15349 | |
| SUPFAM | SSF54452 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0043116 |
negative regulation of vascular permeability |
ECO:0000270 |
P |
Figure 6 demonstrates a decrease in vascular permeability when EPCR is overexpressed in the mice. |
complete | |||||
|
acts_upstream_of_or_within |
GO:0050819 |
negative regulation of coagulation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1305991 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
|
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1305991 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4V8I1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4V8I1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050819 |
negative regulation of coagulation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UNN8 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050819 |
negative regulation of coagulation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007596 |
blood coagulation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007599 |
hemostasis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Finigan, JH et al. (2009) Activated protein C protects against ventilator-induced pulmonary capillary leak. Am. J. Physiol. Lung Cell Mol. Physiol. 296 L1002-11 PubMed GONUTS page
- ↑ 2.0 2.1 Fukudome, K & Esmon, CT (1995) Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR. J. Biol. Chem. 270 5571-7 PubMed GONUTS page
- ↑ 3.0 3.1 Liang, Z et al. (1999) Nucleotide structure and characterization of the murine gene encoding the endothelial cell protein C receptor. Thromb. Haemost. 81 585-8 PubMed GONUTS page
- ↑ Rothbarth, K et al. (1993) cDNA-derived molecular characteristics and antibodies to a new centrosome-associated and G2/M phase-prevalent protein. J. Cell. Sci. 104 ( Pt 1) 19-30 PubMed GONUTS page
