MOUSE:EDN3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Edn3
Protein Name(s)	Endothelin-3 ET-3 Preproendothelin-3 PPET3
External Links
UniProt	P48299
EMBL	U32330 AK048006 AK049775 AK079150
CCDS	CCDS17156.1
PIR	I49351
RefSeq	NP_031929.1
UniGene	Mm.9478
ProteinModelPortal	P48299
PRIDE	P48299
Ensembl	ENSMUST00000029030
GeneID	13616
KEGG	mmu:13616
UCSC	uc008ofi.1
CTD	1908
MGI	MGI:95285
eggNOG	NOG41573
GeneTree	ENSGT00530000063310
HOGENOM	HOG000231110
HOVERGEN	HBG051442
InParanoid	P48299
KO	K05227
OMA	HHRSRRC
OrthoDB	EOG7PCJHP
PhylomeDB	P48299
TreeFam	TF333184
Reactome	REACT_207651 REACT_235286
NextBio	284280
PRO	PR:P48299
Proteomes	UP000000589
Bgee	P48299
CleanEx	MM_EDN3
ExpressionAtlas	P48299
Genevestigator	P48299
GO	GO:0005615 GO:0007166 GO:0006874 GO:0010961 GO:0048016 GO:0030318 GO:0001755 GO:0030182 GO:0030593 GO:0030072 GO:0008284 GO:0010460 GO:0046887 GO:0002690 GO:0043406 GO:0045840 GO:1901381 GO:0030334 GO:0048070 GO:0003100 GO:0019229 GO:0014826
InterPro	IPR020475 IPR019764 IPR001928
Pfam	PF00322
PRINTS	PR00365
SMART	SM00272
PROSITE	PS00270

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048484	enteric nervous system development	PMID 10021336	ECO:0000314			P		Figure 2 shows inhibited neuronal cell development with Et3 in crest derived cells	Missing: reference
	GO:0014043	negative regulation of neuron maturation	PMID 10021336	ECO:0000314			P		Figure 2 shows decreased neuronal maturation, this is concentration dependent. Figure 3 shows similar finding, dose dependent inhibition of enteric neuronal cell maturation	Missing: reference
	GO:0048659	smooth muscle cell proliferation	PMID 10021336	ECO:0000314			P		Figure 5 shows ET3 promotion of smooth muscle cell proliferation.	Missing: reference
	GO:0010629	negative regulation of gene expression	PMID 10021336	ECO:0000314			P		Figure 6 shows decreased expression of lamin alpha 1 in the presence of Et3	Missing: reference
acts_upstream_of_or_within	GO:1901381	positive regulation of potassium ion transmembrane transport	PMID:19544475^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1346053	P	regulates_o_occurs_in:(CL:0000232)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048070	regulation of developmental pigmentation	PMID:14138974^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856392	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046928	regulation of neurotransmitter secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2534	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046888	negative regulation of hormone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2534	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046887	positive regulation of hormone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045597	positive regulation of cell differentiation	PMID:22897442^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042310	vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
enables	GO:0031708	endothelin B receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030593	neutrophil chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	PMID:14138974^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856392	P	regulates_o_results_in_movement_of:(CL:0000541)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030318	melanocyte differentiation	PMID:9012511^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:9624616^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856392	P	occurs_in:(EMAPA:18939) results_in_acquisition_of_features_of:(CL:0000029)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030072	peptide hormone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014826	vein smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010961	cellular magnesium ion homeostasis	PMID:23122227^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103569 MGI:MGI:1346053	P	occurs_in:(CL:0000232)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:22897442^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010460	positive regulation of heart rate	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:11401406^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:22897442^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	PMID:23122227^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103569 MGI:MGI:1346053	P	occurs_in:(CL:0000232)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003100	regulation of systemic arterial blood pressure by endothelin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002690	positive regulation of leukocyte chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001755	neural crest cell migration	PMID:9624616^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856392	P	occurs_in:(EMAPA:18939) results_in_movement_of:(CL:0000333)	Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0006874	C		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
involved_in	GO:0046887	positive regulation of hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
enables	GO:0031708	endothelin B receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	F		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
involved_in	GO:0030072	peptide hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
involved_in	GO:0014826	vein smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
involved_in	GO:0010460	positive regulation of heart rate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	F		Seeded From UniProt	complete
involved_in	GO:0003100	regulation of systemic arterial blood pressure by endothelin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
involved_in	GO:0002690	positive regulation of leukocyte chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14138 ensembl:ENSP00000337128	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001928 InterPro:IPR019764	C		Seeded From UniProt	complete
involved_in	GO:0019229	regulation of vasoconstriction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001928 InterPro:IPR019764	P		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0839	P		Seeded From UniProt	complete
involved_in	GO:0050880	regulation of blood vessel size	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0838	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhu, X et al. (2009) Changes in red cell ion transport, reduced intratumoral neovascularization, and some mild motor function abnormalities accompany targeted disruption of the Mouse Kell gene (Kel). Am. J. Hematol. 84 492-8 PubMed GONUTS page
↑ ^2.0 ^2.1 MAYER, TC & MALTBY, EL (1964) AN EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL SPOTTING AND BELTED MOUSE EMBRYOS. Dev. Biol. 9 269-86 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Evangelisti, C et al. (2012) Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. Neurogastroenterol. Motil. 24 e497-508 PubMed GONUTS page
↑ Reid, K et al. (1996) Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. Development 122 3911-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Howard, MJ & Gershon, MD (1998) Development of LBP110 expression by neural crest-derived enteric precursors: migration and differentiation potential in ls/ls mutant mice. J. Neurobiol. 35 341-54 PubMed GONUTS page
↑ ^6.0 ^6.1 Rivera, A et al. (2013) Ablation of the Kell/Xk complex alters erythrocyte divalent cation homeostasis. Blood Cells Mol. Dis. 50 80-5 PubMed GONUTS page
↑ Wehrle-Haller, B et al. (2001) Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival. Dev. Biol. 232 471-83 PubMed GONUTS page

[PMID:19544475-1] Zhu, X et al. (2009) Changes in red cell ion transport, reduced intratumoral neovascularization, and some mild motor function abnormalities accompany targeted disruption of the Mouse Kell gene (Kel). Am. J. Hematol. 84 492-8 PubMed GONUTS page

[PMID:14138974-2] 2.0 ^2.1 MAYER, TC & MALTBY, EL (1964) AN EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL SPOTTING AND BELTED MOUSE EMBRYOS. Dev. Biol. 9 269-86 PubMed GONUTS page

[PMID:22897442-3] 3.0 ^3.1 ^3.2 Evangelisti, C et al. (2012) Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. Neurogastroenterol. Motil. 24 e497-508 PubMed GONUTS page

[PMID:9012511-4] Reid, K et al. (1996) Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. Development 122 3911-9 PubMed GONUTS page

[PMID:9624616-5] 5.0 ^5.1 Howard, MJ & Gershon, MD (1998) Development of LBP110 expression by neural crest-derived enteric precursors: migration and differentiation potential in ls/ls mutant mice. J. Neurobiol. 35 341-54 PubMed GONUTS page

[PMID:23122227-6] 6.0 ^6.1 Rivera, A et al. (2013) Ablation of the Kell/Xk complex alters erythrocyte divalent cation homeostasis. Blood Cells Mol. Dis. 50 80-5 PubMed GONUTS page

[PMID:11401406-7] Wehrle-Haller, B et al. (2001) Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival. Dev. Biol. 232 471-83 PubMed GONUTS page

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MOUSE:EDN3

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