MOUSE:EAA3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Slc1a1 (synonyms: Eaac1, Eaat3)
Protein Name(s)	Excitatory amino acid transporter 3 Excitatory amino-acid carrier 1 Sodium-dependent glutamate/aspartate transporter 3 Solute carrier family 1 member 1
External Links
UniProt	P51906
EMBL	D43797 U73521 U75217 CH466534 BC065099
CCDS	CCDS29727.1
PIR	S55677
RefSeq	NP_033225.1
UniGene	Mm.246670
ProteinModelPortal	P51906
SMR	P51906
IntAct	P51906
MINT	MINT-2839452
STRING	10090.ENSMUSP00000025875
PhosphoSite	P51906
MaxQB	P51906
PaxDb	P51906
PRIDE	P51906
Ensembl	ENSMUST00000025875
GeneID	20510
KEGG	mmu:20510
UCSC	uc008hcl.1
CTD	6505
MGI	MGI:105083
eggNOG	COG1301
GeneTree	ENSGT00760000119117
HOGENOM	HOG000208776
HOVERGEN	HBG000080
InParanoid	P51906
KO	K05612
OMA	VSAVGWH
OrthoDB	EOG7RV9G2
TreeFam	TF315206
Reactome	REACT_229514 REACT_251788
ChiTaRS	Slc1a1
NextBio	298699
PRO	PR:P51906
Proteomes	UP000000589
Bgee	P51906
ExpressionAtlas	P51906
Genevestigator	P51906
GO	GO:0070062 GO:0016021 GO:0005886 GO:0016595 GO:0015501 GO:0005313 GO:0017153 GO:0070779 GO:0051938 GO:0089711 GO:0015813 GO:0051260
Gene3D	1.10.3860.10
InterPro	IPR001991 IPR018107
PANTHER	PTHR11958
Pfam	PF00375
PRINTS	PR00173
SUPFAM	SSF118215
PROSITE	PS00713 PS00714

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0010460	positive regulation of heart rate	PMID:23361868^[1]	ECO:0000315			P	Figure 1 shows presence of EAAT3 leads to increased heart rate.	complete CACAO 6831
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43005	C	Seeded From UniProt	complete
enables	GO:0015108	chloride transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43005	F	Seeded From UniProt	complete
enables	GO:0005314	high-affinity glutamate transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43005	F	Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43005	P	Seeded From UniProt	complete
involved_in	GO:0140009	L-aspartate import across plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43005	P	Seeded From UniProt	complete
involved_in	GO:0098712	L-glutamate import across plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43005	P	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43005	C	Seeded From UniProt	complete
enables	GO:0033229	cysteine transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43005	F	Seeded From UniProt	complete
involved_in	GO:0042883	cysteine transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43005	P	Seeded From UniProt	complete
involved_in	GO:0010460	positive regulation of heart rate	PMID:23361868^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902476	chloride transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0140009	L-aspartate import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098712	L-glutamate import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070779	D-aspartate import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051938	L-glutamate import	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	PMID:15009636^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P51906	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3696	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042883	cysteine transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	P	Seeded From UniProt	complete
enables	GO:0033229	cysteine transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	F	Seeded From UniProt	complete
enables	GO:0016595	glutamate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3696	F	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:29350434^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015813	L-glutamate transmembrane transport	PMID:15009636^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015813	L-glutamate transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015813	L-glutamate transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3696	P	Seeded From UniProt	complete
enables	GO:0015501	glutamate:sodium symporter activity	PMID:12119102^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015501	glutamate:sodium symporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	F	Seeded From UniProt	complete
enables	GO:0015501	glutamate:sodium symporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3696	F	Seeded From UniProt	complete
enables	GO:0015108	chloride transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15009636^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	C	Seeded From UniProt	complete
enables	GO:0005314	high-affinity glutamate transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	F	Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	PMID:15009636^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43005	F	Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3696	F	Seeded From UniProt	complete
involved_in	GO:1903712	cysteine transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0033229	P	Seeded From UniProt	complete
involved_in	GO:1903712	cysteine transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0033229	P	Seeded From UniProt	complete
involved_in	GO:1903712	cysteine transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0033229	P	Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	P	Seeded From UniProt	complete
involved_in	GO:0140009	L-aspartate import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	P	Seeded From UniProt	complete
involved_in	GO:0098712	L-glutamate import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	P	Seeded From UniProt	complete
involved_in	GO:0070779	D-aspartate import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	P	Seeded From UniProt	complete
involved_in	GO:0051938	L-glutamate import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	P	Seeded From UniProt	complete
involved_in	GO:0042883	cysteine transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	P	Seeded From UniProt	complete
enables	GO:0033229	cysteine transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	F	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	C	Seeded From UniProt	complete
involved_in	GO:0015813	L-glutamate transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	P	Seeded From UniProt	complete
enables	GO:0015501	glutamate:sodium symporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	F	Seeded From UniProt	complete
enables	GO:0015108	chloride transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	C	Seeded From UniProt	complete
enables	GO:0005314	high-affinity glutamate transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	F	Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43005 ensembl:ENSP00000262352	F	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51907 ensembl:ENSRNOP00000020272	P	Seeded From UniProt	complete
enables	GO:0016595	glutamate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51907 ensembl:ENSRNOP00000020272	F	Seeded From UniProt	complete
involved_in	GO:0015813	L-glutamate transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51907 ensembl:ENSRNOP00000020272	P	Seeded From UniProt	complete
enables	GO:0015501	glutamate:sodium symporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51907 ensembl:ENSRNOP00000020272	F	Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51907 ensembl:ENSRNOP00000020272	F	Seeded From UniProt	complete
enables	GO:0015293	symporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001991 InterPro:IPR036458	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001991 InterPro:IPR036458	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0015293	symporter activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0769	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0006865	amino acid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0029	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Deng, J et al. (2013) Glutamate transporter type 3 knockout leads to decreased heart rate possibly via parasympathetic mechanism. Transgenic Res. 22 757-66 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Yang, Y et al. (2004) Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J. Neurochem. 88 1361-72 PubMed GONUTS page
↑ Ottestad-Hansen, S et al. (2018) The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain. Glia 66 951-970 PubMed GONUTS page
↑ Butchbach, ME et al. (2002) Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18. Gene 292 81-90 PubMed GONUTS page

[PMID:23361868-1] 1.0 ^1.1 Deng, J et al. (2013) Glutamate transporter type 3 knockout leads to decreased heart rate possibly via parasympathetic mechanism. Transgenic Res. 22 757-66 PubMed GONUTS page

[PMID:15009636-2] 2.0 ^2.1 ^2.2 ^2.3 Yang, Y et al. (2004) Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J. Neurochem. 88 1361-72 PubMed GONUTS page

[PMID:29350434-3] Ottestad-Hansen, S et al. (2018) The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain. Glia 66 951-970 PubMed GONUTS page

[PMID:12119102-4] Butchbach, ME et al. (2002) Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18. Gene 292 81-90 PubMed GONUTS page

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MOUSE:EAA3

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