MOUSE:DHCR7

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Dhcr7
Protein Name(s)	7-dehydrocholesterol reductase 7-DHC reductase Sterol Delta(7)-reductase
External Links
UniProt	O88455
EMBL	AF057368 BC006854
CCDS	CCDS22048.1
RefSeq	NP_031882.1 XP_006508541.1 XP_006508542.1 XP_006508543.1 XP_006508544.1
UniGene	Mm.249342
ProteinModelPortal	O88455
SMR	O88455
STRING	10090.ENSMUSP00000073541
SwissLipids	SLP:000001320
iPTMnet	O88455
PhosphoSite	O88455
EPD	O88455
MaxQB	O88455
PaxDb	O88455
PRIDE	O88455
TopDownProteomics	O88455
Ensembl	ENSMUST00000073878 ENSMUST00000124340 ENSMUST00000141916
GeneID	13360
KEGG	mmu:13360
UCSC	uc009kqc.1
CTD	1717
MGI	MGI:1298378
eggNOG	KOG1435 ENOG410XP67
GeneTree	ENSGT00390000000417
HOGENOM	HOG000193296
HOVERGEN	HBG007825
InParanoid	O88455
KO	K00213
OMA	ITHALWF
PhylomeDB	O88455
TreeFam	TF101180
Reactome	R-MMU-2426168 R-MMU-6807047 R-MMU-6807062
UniPathway	UPA00063
NextBio	283692
PRO	PR:O88455
Proteomes	UP000000589
Bgee	O88455
CleanEx	MM_DHCR7
ExpressionAtlas	O88455
Genevisible	O88455
GO	GO:0005783 GO:0030176 GO:0016020 GO:0005640 GO:0047598 GO:0001568 GO:0030154 GO:0006695 GO:0030324 GO:0035264 GO:0009791 GO:0042127 GO:0045540 GO:0016126
InterPro	IPR001171 IPR018083
Pfam	PF01222
PROSITE	PS01017 PS01018

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0050661	NADP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G4SW86	F		Seeded From UniProt	complete
enables	GO:0047598	7-dehydrocholesterol reductase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1298378 PANTHER:PTN001082975 RGD:621769 UniProtKB:Q9UBM7	F		Seeded From UniProt	complete
part_of	GO:0030176	integral component of endoplasmic reticulum membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000479179 UniProtKB:Q9LDU6	C		Seeded From UniProt	complete
involved_in	GO:0016132	brassinosteroid biosynthetic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001847198 UniProtKB:Q9LDU6	P		Seeded From UniProt	complete
involved_in	GO:0016126	sterol biosynthetic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1298378 PANTHER:PTN000479179	P		Seeded From UniProt	complete
enables	GO:0009918	sterol delta7 reductase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001847198 UniProtKB:Q9LDU6	F		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001082975 RGD:621769 UniProtKB:Q9UBM7	P		Seeded From UniProt	complete
enables	GO:0047598	7-dehydrocholesterol reductase activity	PMID:11792727^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0047598	7-dehydrocholesterol reductase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBM7	F		Seeded From UniProt	complete
enables	GO:0047598	7-dehydrocholesterol reductase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621769	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045540	regulation of cholesterol biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621769	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621769	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:15005800^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387406	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:15005800^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387406	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:15005800^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387406	P	results_in_development_of:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:15005800^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387406	P	occurs_in:(EMAPA:16728) results_in_acquisition_of_features_of:(CL:0000082)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016126	sterol biosynthetic process	PMID:15005800^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387406	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009791	post-embryonic development	PMID:15005800^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387406	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006695	cholesterol biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006695	cholesterol biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621769	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBM7	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBM7	C		Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBM7	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:15005800^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387406	P	occurs_in:(EMAPA:16728)\|occurs_in:(EMAPA:16201)\|occurs_in:(EMAPA:16240)	Seeded From UniProt	complete
enables	GO:0047598	7-dehydrocholesterol reductase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBM7 ensembl:ENSP00000347717	F		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBM7 ensembl:ENSP00000347717	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBM7 ensembl:ENSP00000347717	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBM7 ensembl:ENSP00000347717	C		Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBM7 ensembl:ENSP00000347717	C		Seeded From UniProt	complete
enables	GO:0047598	7-dehydrocholesterol reductase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2Z8 ensembl:ENSRNOP00000028194	F		Seeded From UniProt	complete
involved_in	GO:0045540	regulation of cholesterol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2Z8 ensembl:ENSRNOP00000028194	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2Z8 ensembl:ENSRNOP00000028194	C		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2Z8 ensembl:ENSRNOP00000028194	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R5F7 ensembl:ENSP00000347717	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R5F7 ensembl:ENSP00000347717	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001171	C		Seeded From UniProt	complete
enables	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018083	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018083	P		Seeded From UniProt	complete
enables	GO:0047598	7-dehydrocholesterol reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.3.1.21	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0006694	steroid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0752	P		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0152 UniPathway:UPA00063	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0016126	sterol biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0756	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Hogenboom, S et al. (2002) Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis. J. Lipid Res. 43 90-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Yu, H et al. (2004) Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. BMC Dev. Biol. 4 1 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11792727-2] Hogenboom, S et al. (2002) Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis. J. Lipid Res. 43 90-8 PubMed GONUTS page

[PMID:15005800-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Yu, H et al. (2004) Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. BMC Dev. Biol. 4 1 PubMed GONUTS page

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MOUSE:DHCR7

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Annotations

Notes

References

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