MOUSE:DEFA4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Defa4 (synonyms: Defcr4)
Protein Name(s)	Alpha-defensin 4 Defensin-related cryptdin-4
External Links
UniProt	P28311
EMBL	AF178040 BC134360 U03032
PIR	I48887
RefSeq	NP_034169.2
UniGene	Mm.426634 Mm.465152
PDB	1TV0 2GW9 2GWP 2LEW 2LEY
PDBsum	1TV0 2GW9 2GWP 2LEW 2LEY
DisProt	DP00388
ProteinModelPortal	P28311
SMR	P28311
TCDB	1.C.19.1.5
PRIDE	P28311
GeneID	13238
KEGG	mmu:13238
UCSC	uc029wro.1
CTD	1669
MGI	MGI:99584
HOVERGEN	HBG011703
InParanoid	P28311
KO	K05230
PhylomeDB	P28311
EvolutionaryTrace	P28311
NextBio	283444
PMAP-CutDB	P28311
PRO	PR:P28311
Proteomes	UP000000589
CleanEx	MM_DEFCR4
Genevestigator	P28311
GO	GO:0005615 GO:0005543 GO:0019731 GO:0042742 GO:0051673
InterPro	IPR016327 IPR006080 IPR002366
PANTHER	PTHR11876
Pfam	PF00879
PIRSF	PIRSF001875
SMART	SM00048

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0031640	killing of cells of other organism	PMID:15297466^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:15297466^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 PANTHER:PTN002275316	P	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P59665 UniProtKB:P59666	P	Seeded From UniProt	complete
involved_in	GO:0051673	membrane disruption in other organism	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99584 MGI:MGI:99592 PANTHER:PTN002275316	P	Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P59666 UniProtKB:P82270 UniProtKB:P82271 UniProtKB:Q01523	P	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 MGI:MGI:99582 PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P82270 UniProtKB:P82271 UniProtKB:Q01523	P	Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915259 MGI:MGI:3630383 MGI:MGI:99584 PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P59666	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915259 MGI:MGI:3630383 MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 MGI:MGI:99584 PANTHER:PTN002275315 UniProtKB:P59666	C	Seeded From UniProt	complete
involved_in	GO:0002227	innate immune response in mucosa	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002275316 UniProtKB:P59665 UniProtKB:P59666	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051673	membrane disruption in other organism	PMID:20056603^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042742	defense response to bacterium	PMID:7927786^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042742	defense response to bacterium	PMID:20056603^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042742	defense response to bacterium	PMID:12574157^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019731	antibacterial humoral response	PMID:21041494^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21041494^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:12574157^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006080	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016327	C	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002366 InterPro:IPR006080 InterPro:IPR016327	P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0044	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0211	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Maemoto, A et al. (2004) Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J. Biol. Chem. 279 44188-96 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Shanahan, MT et al. (2010) Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action. J. Biol. Chem. 285 7493-504 PubMed GONUTS page
↑ Ouellette, AJ et al. (1994) Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect. Immun. 62 5040-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Satchell, DP et al. (2003) Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes. J. Biol. Chem. 278 13838-46 PubMed GONUTS page
↑ ^6.0 ^6.1 Shanahan, MT et al. (2011) Strain-specific polymorphisms in Paneth cell α-defensins of C57BL/6 mice and evidence of vestigial myeloid α-defensin pseudogenes. Infect. Immun. 79 459-73 PubMed GONUTS page

[PMID:15297466-1] 1.0 ^1.1 Maemoto, A et al. (2004) Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J. Biol. Chem. 279 44188-96 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20056603-3] 3.0 ^3.1 Shanahan, MT et al. (2010) Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action. J. Biol. Chem. 285 7493-504 PubMed GONUTS page

[PMID:7927786-4] Ouellette, AJ et al. (1994) Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect. Immun. 62 5040-7 PubMed GONUTS page

[PMID:12574157-5] 5.0 ^5.1 Satchell, DP et al. (2003) Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes. J. Biol. Chem. 278 13838-46 PubMed GONUTS page

[PMID:21041494-6] 6.0 ^6.1 Shanahan, MT et al. (2011) Strain-specific polymorphisms in Paneth cell α-defensins of C57BL/6 mice and evidence of vestigial myeloid α-defensin pseudogenes. Infect. Immun. 79 459-73 PubMed GONUTS page

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MOUSE:DEFA4

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