MOUSE:DBC1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Brinp1 (synonyms: Brinp, Dbc1, Dbccr1, Fam5a)
Protein Name(s)	BMP/retinoic acid-inducible neural-specific protein 1 Deleted in bladder cancer protein 1 homolog
External Links
UniProt	Q920P3
EMBL	AB060587 AB060589 AB088118 AF202896 AK028321 AK045420 BX088573 BX649413 BX649413 BX088573 BC048789 BC079630
CCDS	CCDS18272.1
RefSeq	NP_064351.2
UniGene	Mm.248788
ProteinModelPortal	Q920P3
SMR	Q920P3
IntAct	Q920P3
STRING	10090.ENSMUSP00000030036
PhosphoSite	Q920P3
MaxQB	Q920P3
PaxDb	Q920P3
PRIDE	Q920P3
Ensembl	ENSMUST00000030036
GeneID	56710
KEGG	mmu:56710
UCSC	uc008thw.1 uc008thx.1
CTD	1620
MGI	MGI:1928478
eggNOG	NOG38997
GeneTree	ENSGT00390000008571
HOGENOM	HOG000049122
HOVERGEN	HBG081412
InParanoid	Q920P3
OMA	HSEGWSM
OrthoDB	EOG764720
PhylomeDB	Q920P3
TreeFam	TF331600
NextBio	313175
PRO	PR:Q920P3
Proteomes	UP000000589
Bgee	Q920P3
CleanEx	MM_DBC1
Genevestigator	Q920P3
GO	GO:0005737 GO:0007050 GO:0008219 GO:0071300 GO:0045786 GO:0045930 GO:0045666
InterPro	IPR020864
Pfam	PF01823
SMART	SM00457

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0071300	cellular response to retinoic acid	PMID:20025061^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	PMID:20025061^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60477	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:20025061^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008219	cell death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60477	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60477	C		Seeded From UniProt	complete
part_of	GO:0005575	cellular_component	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928478 MGI:MGI:2443035 MGI:MGI:2443333 PANTHER:PTN001036861	P		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928478 MGI:MGI:2443035 MGI:MGI:2443333 PANTHER:PTN001036861	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928478 MGI:MGI:2443035 MGI:MGI:2443333 PANTHER:PTN001036861	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001036861 RGD:708419 RGD:708421	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001036861 RGD:708419 RGD:708421	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001036861 RGD:708419 RGD:708421	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071625	vocalization behavior	PMID:27042284^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5604542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050768	negative regulation of neurogenesis	PMID:24528488^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5698819	P	regulates_o_occurs_in:(EMAPA:35831)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045786	negative regulation of cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60477	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042711	maternal behavior	PMID:27042284^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5604542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035640	exploration behavior	PMID:27042284^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5604542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	PMID:27042284^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5604542	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	PMID:24528488^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5698819	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008219	cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60477	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007614	short-term memory	PMID:27042284^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5604542	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60477	C		Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001662	behavioral fear response	PMID:24528488^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5698819	P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60477 ensembl:ENSP00000265922	P		Seeded From UniProt	complete
involved_in	GO:0008219	cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60477 ensembl:ENSP00000265922	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60477 ensembl:ENSP00000265922	C		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033237	P		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033237	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0338	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Terashima, M et al. (2010) Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells. J. Neurosci. Res. 88 1387-93 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Berkowicz, SR et al. (2016) Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density. Mol Autism 7 22 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Kobayashi, M et al. (2014) Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders. Mol Brain 7 12 PubMed GONUTS page

[PMID:20025061-1] 1.0 ^1.1 ^1.2 Terashima, M et al. (2010) Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells. J. Neurosci. Res. 88 1387-93 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27042284-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Berkowicz, SR et al. (2016) Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density. Mol Autism 7 22 PubMed GONUTS page

[PMID:24528488-4] 4.0 ^4.1 ^4.2 Kobayashi, M et al. (2014) Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders. Mol Brain 7 12 PubMed GONUTS page

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MOUSE:DBC1

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