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MOUSE:COPT1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Slc31a1
Protein Name(s) High affinity copper uptake protein 1

Copper transporter 1 CTR1 Solute carrier family 31 member 1

External Links
UniProt Q8K211
EMBL AK046835
AK151337
AL732548
BC034674
BC058227
CCDS CCDS18237.1
RefSeq NP_780299.2
XP_006537774.1
UniGene Mm.248637
ProteinModelPortal Q8K211
SMR Q8K211
STRING 10090.ENSMUSP00000081574
PhosphoSite Q8K211
MaxQB Q8K211
PaxDb Q8K211
PRIDE Q8K211
Ensembl ENSMUST00000084526
GeneID 20529
KEGG mmu:20529
UCSC uc008ten.2
CTD 1317
MGI MGI:1333843
eggNOG NOG323808
GeneTree ENSGT00530000063415
HOGENOM HOG000195393
HOVERGEN HBG065767
InParanoid Q8K211
KO K14686
OMA WHIETVA
OrthoDB EOG7S220Q
PhylomeDB Q8K211
TreeFam TF315142
Reactome REACT_251299
ChiTaRS Slc31a1
NextBio 298779
PRO PR:Q8K211
Proteomes UP000000589
Bgee Q8K211
CleanEx MM_SLC31A1
ExpressionAtlas Q8K211
Genevestigator Q8K211
GO GO:0016021
GO:0005770
GO:0043025
GO:0005886
GO:0055037
GO:0015088
GO:0006878
GO:0072719
GO:0015677
GO:1902861
GO:0006855
InterPro IPR007274
PANTHER PTHR12483
Pfam PF04145

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016324

PMID:20699218[1]

ECO:0000314

Figures 2 and 3. The localization of Ctr1 was determined by immunohistochemistry.

complete

involved_in

GO:0006878

cellular copper ion homeostasis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0062412
FB:FBgn0062413
MGI:MGI:1333843
MGI:MGI:1333844
PANTHER:PTN000280760
SGD:S000001218

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000196962
FB:FBgn0062411
FB:FBgn0062413
PANTHER:PTN000280760
PomBase:SPAC1142.05
PomBase:SPBC23G7.16
PomBase:SPCC1393.10
RGD:620059
SGD:S000004403
SGD:S000006328
TAIR:locus:2102752
UniProtKB:Q60EN8
UniProtKB:Q8IL79
UniProtKB:Q94EE4
dictyBase:DDB_G0287297

C

Seeded From UniProt

complete

enables

GO:0005375

copper ion transmembrane transporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000196962
FB:FBgn0062411
FB:FBgn0062412
FB:FBgn0062413
MGI:MGI:1333843
PANTHER:PTN000280760
PomBase:SPAC1142.05
PomBase:SPBC23G7.16
PomBase:SPCC1393.10
RGD:620059
SGD:S000001218
SGD:S000004403
SGD:S000006328
TAIR:locus:2102752
TAIR:locus:2153306
TAIR:locus:2153311
TAIR:locus:2180474
TAIR:locus:504955905
UniProtKB:Q60EN8
UniProtKB:Q94EE4

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0098705

copper ion import across plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620059

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072719

cellular response to cisplatin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620059

P

Seeded From UniProt

complete

part_of

GO:0055037

recycling endosome

PMID:24167251[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620059

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O15431

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015677

copper ion import

PMID:12177073[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388121

P

occurs_in:(CL:0002321)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015677

copper ion import

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620059

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006878

cellular copper ion homeostasis

PMID:24167251[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1333844

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006855

drug transmembrane transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620059

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620059

C

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

PMID:24167251[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620059

C

Seeded From UniProt

complete

enables

GO:0005375

copper ion transmembrane transporter activity

PMID:12177073[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388121

F

occurs_in:(CL:0002321)

Seeded From UniProt

complete

enables

GO:0005375

copper ion transmembrane transporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620059

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O15431
ensembl:ENSP00000363329

F

Seeded From UniProt

complete

involved_in

GO:0098705

copper ion import across plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JK41
ensembl:ENSRNOP00000019544

P

Seeded From UniProt

complete

involved_in

GO:0072719

cellular response to cisplatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JK41
ensembl:ENSRNOP00000019544

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JK41
ensembl:ENSRNOP00000019544

C

Seeded From UniProt

complete

involved_in

GO:0015677

copper ion import

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JK41
ensembl:ENSRNOP00000019544

P

Seeded From UniProt

complete

involved_in

GO:0006855

drug transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JK41
ensembl:ENSRNOP00000019544

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JK41
ensembl:ENSRNOP00000019544

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JK41
ensembl:ENSRNOP00000019544

C

Seeded From UniProt

complete

enables

GO:0005375

copper ion transmembrane transporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JK41
ensembl:ENSRNOP00000019544

F

Seeded From UniProt

complete

enables

GO:0005375

copper ion transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007274

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007274

C

Seeded From UniProt

complete

involved_in

GO:0035434

copper ion transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007274

P

Seeded From UniProt

complete

involved_in

GO:0006825

copper ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0187

P

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Nose, Y et al. (2010) Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. J. Biol. Chem. 285 32385-92 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Öhrvik, H et al. (2013) Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. Proc. Natl. Acad. Sci. U.S.A. 110 E4279-88 PubMed GONUTS page
  4. ↑ 4.0 4.1 Lee, J et al. (2002) Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. J. Biol. Chem. 277 40253-9 PubMed GONUTS page
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