MOUSE:COLI

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pomc (synonyms: Pomc1)
Protein Name(s)	Pro-opiomelanocortin POMC Corticotropin-lipotropin NPP Melanotropin gamma Gamma-MSH Corticotropin Adrenocorticotropic hormone ACTH Melanotropin alpha Alpha-MSH Corticotropin-like intermediary peptide CLIP Lipotropin beta Beta-LPH Lipotropin gamma Gamma-LPH Melanotropin beta Beta-MSH Beta-endorphin Met-enkephalin
External Links
UniProt	P01193
EMBL	J00612 J00611 V01528 V01529 AK017492 AK017581 AK030714 AK077426 AK133592 AK133646 AK133740 AK133776 AK133800 BC061215 M30489 V00831
CCDS	CCDS25785.1
PIR	A91312
RefSeq	NP_001265510.1 NP_001265511.1 NP_001265512.1 NP_001265513.1 NP_032921.1
UniGene	Mm.277996
ProteinModelPortal	P01193
PhosphoSite	P01193
UniCarbKB	P01193
PaxDb	P01193
PRIDE	P01193
Ensembl	ENSMUST00000020990
GeneID	18976
KEGG	mmu:18976
UCSC	uc007mxe.1
CTD	5443
MGI	MGI:97742
eggNOG	NOG45039
GeneTree	ENSGT00390000016811
HOGENOM	HOG000111887
HOVERGEN	HBG004341
InParanoid	P01193
KO	K05228
OMA	RACKPDL
OrthoDB	EOG74TX0W
PhylomeDB	P01193
TreeFam	TF333215
Reactome	REACT_205726 REACT_207160 REACT_220332 REACT_227038 REACT_235286 REACT_242718 REACT_242845 REACT_242871 REACT_250376
ChiTaRS	Pomc
NextBio	295340
PMAP-CutDB	P01193
PRO	PR:P01193
Proteomes	UP000000589
Bgee	P01193
CleanEx	MM_POMC
Genevestigator	P01193
GO	GO:0005737 GO:0005615 GO:0005782 GO:0030141 GO:0001664 GO:0005179 GO:0070996 GO:0007267 GO:0033059 GO:0006091 GO:0042593 GO:0032720 GO:0007218 GO:0045944 GO:0032098 GO:0008217 GO:2000852 GO:0070873 GO:0007165
InterPro	IPR001941 IPR013531 IPR013593 IPR013532
Pfam	PF00976 PF08384 PF08035
PRINTS	PR00383

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0070996	type 1 melanocortin receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01189	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
involved_in	GO:0033059	cellular pigmentation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
involved_in	GO:0032098	regulation of appetite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
involved_in	GO:0006091	generation of precursor metabolites and energy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01189	C		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01189	F		Seeded From UniProt	complete
involved_in	GO:2000852	regulation of corticosterone secretion	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97742 PANTHER:PTN000151801	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97742 PANTHER:PTN000151801	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000151801 UniProtKB:P01189	C		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000151801 UniProtKB:P01189	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000852	regulation of corticosterone secretion	PMID:21184805^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2687084	P		Seeded From UniProt	complete
enables	GO:0070996	type 1 melanocortin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070873	regulation of glycogen metabolic process	PMID:21184805^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2687084	P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:21184805^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2687084	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033059	cellular pigmentation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032098	regulation of appetite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
enables	GO:0031782	type 4 melanocortin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	F		Seeded From UniProt	complete
enables	GO:0031781	type 3 melanocortin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	F		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:16219686^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:1329576^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17515) part_of:(CL:0000467)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008217	regulation of blood pressure	PMID:16243970^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88105 MGI:MGI:88106	P	has_participant:(EMAPA:16104)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006091	generation of precursor metabolites and energy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18388149^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16219686^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3366	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:15467755^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	F		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01189	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
enables	GO:0070996	type 1 melanocortin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	P		Seeded From UniProt	complete
involved_in	GO:0033059	cellular pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	P		Seeded From UniProt	complete
involved_in	GO:0032098	regulation of appetite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	P		Seeded From UniProt	complete
enables	GO:0031782	type 4 melanocortin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	F		Seeded From UniProt	complete
enables	GO:0031781	type 3 melanocortin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	F		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	P		Seeded From UniProt	complete
involved_in	GO:0006091	generation of precursor metabolites and energy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	F		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01189 ensembl:ENSP00000384092	F		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001941	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001941	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-MMU-9623076	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0257	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Saedler, K & Hochgeschwender, U (2011) Impaired neonatal survival of pro-opiomelanocortin null mutants. Mol. Cell. Endocrinol. 336 6-13 PubMed GONUTS page
↑ ^3.0 ^3.1 Hosaka, M et al. (2005) Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules. J. Cell. Sci. 118 4785-95 PubMed GONUTS page
↑ Wilson, DB & Wyatt, DP (1992) Adrenocorticotropic cell distribution in adult and embryonic pituitaries of the little (lit) mutant mouse. Anat. Embryol. 186 347-53 PubMed GONUTS page
↑ Dostanic-Larson, I et al. (2005) The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proc. Natl. Acad. Sci. U.S.A. 102 15845-50 PubMed GONUTS page
↑ Lavoie, PL et al. (2008) Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin. Mol. Endocrinol. 22 1647-57 PubMed GONUTS page
↑ Ciais, D et al. (2004) Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. Oncogene 23 8673-80 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21184805-2] 2.0 ^2.1 ^2.2 Saedler, K & Hochgeschwender, U (2011) Impaired neonatal survival of pro-opiomelanocortin null mutants. Mol. Cell. Endocrinol. 336 6-13 PubMed GONUTS page

[PMID:16219686-3] 3.0 ^3.1 Hosaka, M et al. (2005) Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules. J. Cell. Sci. 118 4785-95 PubMed GONUTS page

[PMID:1329576-4] Wilson, DB & Wyatt, DP (1992) Adrenocorticotropic cell distribution in adult and embryonic pituitaries of the little (lit) mutant mouse. Anat. Embryol. 186 347-53 PubMed GONUTS page

[PMID:16243970-5] Dostanic-Larson, I et al. (2005) The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proc. Natl. Acad. Sci. U.S.A. 102 15845-50 PubMed GONUTS page

[PMID:18388149-6] Lavoie, PL et al. (2008) Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin. Mol. Endocrinol. 22 1647-57 PubMed GONUTS page

[PMID:15467755-7] Ciais, D et al. (2004) Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. Oncogene 23 8673-80 PubMed GONUTS page

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MOUSE:COLI

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