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MOUSE:CO7A1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Col7a1 (ECO:0000312 with MGI:MGI:88462)
Protein Name(s) Collagen alpha-1(VII) chain

Long-chain collagen LC collagen

External Links
UniProt Q63870
EMBL U32107
AC174646
S63654
CCDS CCDS40770.1
PIR A45748
RefSeq NP_031764.2
XP_006511998.1
UniGene Mm.6200
ProteinModelPortal Q63870
SMR Q63870
IntAct Q63870
MINT MINT-4109970
MEROPS I02.967
PhosphoSite Q63870
PaxDb Q63870
PRIDE Q63870
Ensembl ENSMUST00000026740
ENSMUST00000112070
GeneID 12836
KEGG mmu:12836
UCSC uc009rrh.1
CTD 1294
MGI MGI:88462
eggNOG NOG12793
GeneTree ENSGT00770000120467
HOGENOM HOG000111866
HOVERGEN HBG051053
InParanoid Q63870
KO K16628
OMA WHSGHGP
OrthoDB EOG7CG6Z4
PhylomeDB Q63870
TreeFam TF351645
Reactome REACT_196595
REACT_198984
REACT_199046
REACT_199055
REACT_202342
REACT_206066
REACT_216309
NextBio 282356
PRO PR:Q63870
Proteomes UP000000589
Bgee Q63870
CleanEx MM_COL7A1
Genevestigator Q63870
GO GO:0005604
GO:0005581
GO:0005576
GO:0005615
GO:0042802
GO:0004867
GO:0007155
Gene3D 2.60.40.10
3.40.50.410
4.10.410.10
InterPro IPR008160
IPR003961
IPR013783
IPR002223
IPR020901
IPR002035
Pfam PF01391
PF00041
PF00014
PF00092
PRINTS PR00759
SMART SM00060
SM00327
SUPFAM SSF49265
SSF53300
SSF57362
PROSITE PS00280
PS50279
PS50853
PS50234

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28071719[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0000006)

Seeded From UniProt

complete

enables

GO:0030020

extracellular matrix structural constituent conferring tensile strength

PMID:28071719[1]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0000006)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:22159717[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0002048)|part_of:(UBERON:0001155)

Seeded From UniProt

complete

enables

GO:0030020

extracellular matrix structural constituent conferring tensile strength

PMID:22159717[2]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0002048)|occurs_in:(UBERON:0001155)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109613
MGI:MGI:1341272
MGI:MGI:1921449
MGI:MGI:2179729
MGI:MGI:2684334
MGI:MGI:88462
PANTHER:PTN001523162
UniProtKB:O43405
ZFIN:ZDB-GENE-030131-9889

C

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106591
MGI:MGI:109613
MGI:MGI:1278313
MGI:MGI:1328350
MGI:MGI:1921449
MGI:MGI:2179729
MGI:MGI:88459
MGI:MGI:88460
MGI:MGI:88461
PANTHER:PTN001523162
UniProtKB:P12111

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2684334
MGI:MGI:88461
MGI:MGI:96924
PANTHER:PTN001523162
RGD:3055
RGD:67380
UniProtKB:P11226
UniProtKB:Q5GFL6

C

Seeded From UniProt

complete

involved_in

GO:0003429

growth plate cartilage chondrocyte morphogenesis

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106591
PANTHER:PTN001523162

P

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

PMID:19651211[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:17525)

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

PMID:18757743[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16039)

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21570975[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q63870

F

Seeded From UniProt

complete

involved_in

GO:0010951

negative regulation of endopeptidase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004867

P

Seeded From UniProt

complete

involved_in

GO:0010951

negative regulation of endopeptidase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004867

P

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002223
InterPro:IPR036880

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-NUL-4084497

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

part_of

GO:0005581

collagen trimer

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0176

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0722

F

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0084
UniProtKB-SubCell:SL-0025

C

Seeded From UniProt

complete

involved_in

GO:0010466

negative regulation of peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0646

P

Seeded From UniProt

complete

enables

GO:0030414

peptidase inhibitor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0646

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
  2. 2.0 2.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. Gebauer, JM et al. (2009) Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment. Matrix Biol. 28 456-62 PubMed GONUTS page
  5. Manabe, R et al. (2008) Transcriptome-based systematic identification of extracellular matrix proteins. Proc. Natl. Acad. Sci. U.S.A. 105 12849-54 PubMed GONUTS page
  6. Leineweber, S et al. (2011) Insight into interactions of the von-Willebrand-factor-A-like domain 2 with the FNIII-like domain 9 of collagen VII by NMR and SPR. FEBS Lett. 585 1748-52 PubMed GONUTS page