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MOUSE:CO4A4

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Col4a4 (ECO:0000312 with MGI:MGI:104687)
Protein Name(s) Collagen alpha-4(IV) chain
External Links
UniProt Q9QZR9
EMBL AF169388
BC117709
Z35167
CCDS CCDS35630.1
PIR I48303
RefSeq NP_031761.1
UniGene Mm.40253
Mm.479772
ProteinModelPortal Q9QZR9
SMR Q9QZR9
PhosphoSite Q9QZR9
PaxDb Q9QZR9
PRIDE Q9QZR9
Ensembl ENSMUST00000087050
GeneID 12829
KEGG mmu:12829
UCSC uc007brt.1
CTD 1286
MGI MGI:104687
eggNOG NOG12793
GeneTree ENSGT00770000120455
HOGENOM HOG000085652
HOVERGEN HBG004933
InParanoid Q9QZR9
KO K06237
OMA PGFRGDM
OrthoDB EOG7RZ5P3
PhylomeDB Q9QZR9
TreeFam TF344135
Reactome REACT_196595
REACT_196606
REACT_196607
REACT_198984
REACT_199046
REACT_199055
REACT_202342
REACT_206066
REACT_216309
REACT_236183
REACT_263353
NextBio 282326
PRO PR:Q9QZR9
Proteomes UP000000589
Bgee Q9QZR9
CleanEx MM_COL4A4
ExpressionAtlas Q9QZR9
Genevestigator Q9QZR9
GO GO:0005605
GO:0005604
GO:0005587
GO:0005201
GO:0032836
Gene3D 2.170.240.10
InterPro IPR016187
IPR008160
IPR001442
Pfam PF01413
PF01391
SMART SM00111
SUPFAM SSF56436
PROSITE PS51403

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28071719[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0000006)

Seeded From UniProt

complete

enables

GO:0030020

extracellular matrix structural constituent conferring tensile strength

PMID:28071719[1]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0000006)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:22159717[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0002048)|part_of:(UBERON:0001155)

Seeded From UniProt

complete

enables

GO:0030020

extracellular matrix structural constituent conferring tensile strength

PMID:22159717[2]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0002048)|occurs_in:(UBERON:0001155)

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P53420

C

Seeded From UniProt

complete

part_of

GO:0005587

collagen type IV trimer

PMID:7962065[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:7962065[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P55268

F

Seeded From UniProt

complete

involved_in

GO:0032836

glomerular basement membrane development

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104687
PANTHER:PTN002513086
UniProtKB:P53420

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88445
MGI:MGI:88446
MGI:MGI:88452
MGI:MGI:88453
MGI:MGI:88457
MGI:MGI:88467
PANTHER:PTN002513067

C

Seeded From UniProt

complete

involved_in

GO:0030198

extracellular matrix organization

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1095415
MGI:MGI:2152695
MGI:MGI:2672118
MGI:MGI:88451
PANTHER:PTN002513067
WB:WBGene00001263
ZFIN:ZDB-GENE-030131-2281

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88452
MGI:MGI:88468
PANTHER:PTN002513067
RGD:61817
RGD:70936
RGD:727898
UniProtKB:P02452
UniProtKB:P02458
UniProtKB:P02461
UniProtKB:P08123
UniProtKB:Q9BXS0

C

Seeded From UniProt

complete

part_of

GO:0005587

collagen type IV trimer

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104687
PANTHER:PTN002513086
UniProtKB:P53420

C

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104687
MGI:MGI:2672118
MGI:MGI:88457
MGI:MGI:88467
PANTHER:PTN002513067
UniProtKB:P02461
UniProtKB:P02462
UniProtKB:P53420

F

Seeded From UniProt

complete

involved_in

GO:0001886

endothelial cell morphogenesis

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88451
PANTHER:PTN001931637

P

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88451
PANTHER:PTN001931637

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032836

glomerular basement membrane development

PMID:10534397[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857960

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032836

glomerular basement membrane development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P53420

P

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

PMID:9264260[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

PMID:19275937[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

PMID:11732842[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

PMID:10534397[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P53420

C

Seeded From UniProt

complete

part_of

GO:0005587

collagen type IV trimer

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P53420

C

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P53420

F

Seeded From UniProt

complete

involved_in

GO:0032836

glomerular basement membrane development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P53420
ensembl:ENSP00000379866

P

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P53420
ensembl:ENSP00000379866

C

Seeded From UniProt

complete

part_of

GO:0005587

collagen type IV trimer

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P53420
ensembl:ENSP00000379866

C

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P53420
ensembl:ENSP00000379866

F

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001442
InterPro:IPR036954

F

Seeded From UniProt

complete

part_of

GO:0005581

collagen trimer

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001442
InterPro:IPR036954

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

part_of

GO:0005581

collagen trimer

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0176

C

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0084
UniProtKB-SubCell:SL-0025

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
  2. ↑ 2.0 2.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
  3. ↑ 3.0 3.1 Miner, JH & Sanes, JR (1994) Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches. J. Cell Biol. 127 879-91 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 Lu, W et al. (1999) Insertional mutation of the collagen genes Col4a3 and Col4a4 in a mouse model of Alport syndrome. Genomics 61 113-24 PubMed GONUTS page
  6. ↑ Qin, P et al. (1997) Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye. Dev. Dyn. 209 367-76 PubMed GONUTS page
  7. ↑ Bai, X et al. (2009) Developmental distribution of collagen IV isoforms and relevance to ocular diseases. Matrix Biol. 28 194-201 PubMed GONUTS page
  8. ↑ Nagai, N et al. (2001) Localization of type IV collagen a 1 to a 6 chains in basement membrane during mouse molar germ development. Int. J. Dev. Biol. 45 827-31 PubMed GONUTS page
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