MOUSE:CNTP2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cntnap2 (synonyms: Kiaa0868)
Protein Name(s)	Contactin-associated protein-like 2 Cell recognition molecule Caspr2
External Links
UniProt	Q9CPW0
EMBL	AK017341 AK013139 AK129232 BC029826 BC064467
CCDS	CCDS20094.1 CCDS39475.1
RefSeq	NP_001004357.2 NP_080047.1
UniGene	Mm.440084
ProteinModelPortal	Q9CPW0
SMR	Q9CPW0
STRING	10090.ENSMUSP00000064082
PhosphoSite	Q9CPW0
MaxQB	Q9CPW0
PaxDb	Q9CPW0
PRIDE	Q9CPW0
Ensembl	ENSMUST00000060839
GeneID	66797
KEGG	mmu:66797
CTD	26047
MGI	MGI:1914047
eggNOG	NOG291100
GeneTree	ENSGT00760000118991
HOGENOM	HOG000230964
HOVERGEN	HBG057718
InParanoid	Q9CPW0
KO	K07380
PhylomeDB	Q9CPW0
ChiTaRS	Cntnap2
NextBio	322675
PRO	PR:Q9CPW0
Proteomes	UP000000589
Bgee	Q9CPW0
CleanEx	MM_CNTNAP2
ExpressionAtlas	Q9CPW0
Genevestigator	Q9CPW0
GO	GO:0030673 GO:0030424 GO:0009986 GO:0030425 GO:0005769 GO:0005794 GO:0016021 GO:0044224 GO:0016020 GO:0043025 GO:0043204 GO:0019899 GO:0007155 GO:0034613 GO:0045163 GO:0021761 GO:0031175 GO:0008038 GO:0071205
Gene3D	2.60.120.200 2.60.120.260
InterPro	IPR029831 IPR000421 IPR013320 IPR000742 IPR002181 IPR008979 IPR001791 IPR003585
PANTHER	PTHR10127:SF4
Pfam	PF00008 PF00754 PF02210
SMART	SM00294 SM00181 SM00231 SM00282
SUPFAM	SSF49785 SSF49899 SSF56496
PROSITE	PS50026 PS01285 PS01286 PS50022 PS51406 PS50025

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0071205	protein localization to juxtaparanode region of axon	PMID:22338029^[1]	ECO:0000315			P		Figure 3	complete
part_of	GO:0044224	juxtaparanode region of axon	PMID:25378149^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:25378149^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071205	protein localization to juxtaparanode region of axon	PMID:25378149^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071205	protein localization to juxtaparanode region of axon	PMID:12963709^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0008076	voltage-gated potassium channel complex	PMID:11567047^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:11567047^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044224	juxtaparanode region of axon	PMID:11567047^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045163	clustering of voltage-gated potassium channels	PMID:12963709^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0044224	juxtaparanode region of axon	PMID:12963709^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044224	juxtaparanode region of axon	PMID:12975355^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030673	axolemma	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UHC6	C		Seeded From UniProt	complete
involved_in	GO:0021761	limbic system development	PMID:18179895^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UHC6	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UHC6	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UHC6	C		Seeded From UniProt	complete
colocalizes_with	GO:0008076	voltage-gated potassium channel complex	PMID:12975355^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UHC6	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UHC6	C		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307076	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071625	vocalization behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHC6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071205	protein localization to juxtaparanode region of axon	PMID:19109503^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2677631	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307076	F		Seeded From UniProt	complete
part_of	GO:0044224	juxtaparanode region of axon	PMID:18760366^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32845) part_of:(CL:0000117)\|part_of:(EMAPA:35745) part_of:(CL:0000117)\|part_of:(EMAPA:17787) part_of:(CL:0000117)\|part_of:(EMAPA:32809) part_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0044224	juxtaparanode region of axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307076	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307076	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042297	vocal learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHC6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHC6	P		Seeded From UniProt	complete
part_of	GO:0033270	paranode region of axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307076	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	PMID:19458237^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104518	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000540)\|occurs_in:(EMAPA:16668) occurs_in:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030673	axolemma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHC6	C		Seeded From UniProt	complete
part_of	GO:0030673	axolemma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307076	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030534	adult behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHC6	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307076	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHC6	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHC6	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHC6	C		Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHC6	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHC6	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307076	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHC6	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UHC6	C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307076	F		Seeded From UniProt	complete
involved_in	GO:0071205	protein localization to juxtaparanode region of axon	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029831	P		Seeded From UniProt	complete
involved_in	GO:0008038	neuron recognition	PMID:18987363^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:18987363^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0033010	paranodal junction	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0192	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Becker, EB et al. (2012) Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia. J. Neurol. Neurosurg. Psychiatr. 83 437-40 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gordon, A et al. (2014) Caspr and caspr2 are required for both radial and longitudinal organization of myelinated axons. J. Neurosci. 34 14820-6 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Poliak, S et al. (2003) Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J. Cell Biol. 162 1149-60 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Poliak, S et al. (2001) Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon. J. Neurosci. 21 7568-75 PubMed GONUTS page
↑ ^5.0 ^5.1 Traka, M et al. (2003) Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J. Cell Biol. 162 1161-72 PubMed GONUTS page
↑ Bakkaloglu, B et al. (2008) Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am. J. Hum. Genet. 82 165-73 PubMed GONUTS page
↑ Horresh, I et al. (2008) Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons. J. Neurosci. 28 14213-22 PubMed GONUTS page
↑ Savvaki, M et al. (2008) Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes. Mol. Cell. Neurosci. 39 478-90 PubMed GONUTS page
↑ Lieberoth, A et al. (2009) Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth. J. Neurosci. 29 6677-90 PubMed GONUTS page
↑ ^10.0 ^10.1 Vernes, SC et al. (2008) A functional genetic link between distinct developmental language disorders. N. Engl. J. Med. 359 2337-45 PubMed GONUTS page

[PMID:22338029-1] Becker, EB et al. (2012) Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia. J. Neurol. Neurosurg. Psychiatr. 83 437-40 PubMed GONUTS page

[PMID:25378149-2] 2.0 ^2.1 ^2.2 Gordon, A et al. (2014) Caspr and caspr2 are required for both radial and longitudinal organization of myelinated axons. J. Neurosci. 34 14820-6 PubMed GONUTS page

[PMID:12963709-3] 3.0 ^3.1 ^3.2 Poliak, S et al. (2003) Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J. Cell Biol. 162 1149-60 PubMed GONUTS page

[PMID:11567047-4] 4.0 ^4.1 ^4.2 Poliak, S et al. (2001) Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon. J. Neurosci. 21 7568-75 PubMed GONUTS page

[PMID:12975355-5] 5.0 ^5.1 Traka, M et al. (2003) Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J. Cell Biol. 162 1161-72 PubMed GONUTS page

[PMID:18179895-6] Bakkaloglu, B et al. (2008) Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am. J. Hum. Genet. 82 165-73 PubMed GONUTS page

[PMID:19109503-7] Horresh, I et al. (2008) Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons. J. Neurosci. 28 14213-22 PubMed GONUTS page

[PMID:18760366-8] Savvaki, M et al. (2008) Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes. Mol. Cell. Neurosci. 39 478-90 PubMed GONUTS page

[PMID:19458237-9] Lieberoth, A et al. (2009) Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth. J. Neurosci. 29 6677-90 PubMed GONUTS page

[PMID:18987363-10] 10.0 ^10.1 Vernes, SC et al. (2008) A functional genetic link between distinct developmental language disorders. N. Engl. J. Med. 359 2337-45 PubMed GONUTS page

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MOUSE:CNTP2

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